Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2015, 3(4), 281-284
DOI: 10.12691/jfnr-3-4-8
Open AccessArticle

Inhibitory Effect of Cancer Cells Proliferation from Epigallocatechin-3-O-gallate

Hyun Woo Kang1,

1Department of Korean Food & Culinary Arts, Youngsan University, Busan, Korea

Pub. Date: April 27, 2015

Cite this paper:
Hyun Woo Kang. Inhibitory Effect of Cancer Cells Proliferation from Epigallocatechin-3-O-gallate. Journal of Food and Nutrition Research. 2015; 3(4):281-284. doi: 10.12691/jfnr-3-4-8


Epigallocatechin-3-O-gallate (EGCG), the major polyphenol of green tea and a functional food ingredient/nutraceutical with health-promoting properties. However, its anti-cancer activities on various cancer cells are still little information. Here, we show that anti-cancer activities of the EGCG were evaluated using apoptosis assays analyzed by flow cytometry. The inhibitory activities of proliferation in MPC-11, Caco-2, and MCF-7 cells, values were 66.2, 60.3, and 74.8% at 10 μM, respectively. In addition, in an flow cytometry assay on the MPC-11, Caco-2, and MCF-7 cells, the EGCG showed a cell apoptosis effect on cancer/tomor in vitro model. Our results indicate that EGCG has anti-cancer activities against human lung cancer cells through inducing cell cycle arrest, DNA damage and activating mitochondrial signal pathway. These results indicate that EGCG effectively inhibits in vitro tumor growth by inducing apoptosis of cancer cells.

EGCG cancer/tumor cell apoptosis flow cytometer

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