Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2015, 3(3), 202-205
DOI: 10.12691/jfnr-3-3-12
Open AccessArticle

Rutin Attenuates Lipopolysaccharide-induced Nitric Oxide Production in Macrophage Cells

Seung-Jae Lee1, Seung Yuan Lee1, Hyun Joo Ha2, Seon Heui Cha3, Si Kyung Lee4 and Sun Jin Hur1,

1Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea

2Department of Food Science & Nutrition, Dong-A University, Busan, Korea

3Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea

4Department of Bioresources and Food Science, Konkuk University, Seoul, Korea

Pub. Date: March 24, 2015

Cite this paper:
Seung-Jae Lee, Seung Yuan Lee, Hyun Joo Ha, Seon Heui Cha, Si Kyung Lee and Sun Jin Hur. Rutin Attenuates Lipopolysaccharide-induced Nitric Oxide Production in Macrophage Cells. Journal of Food and Nutrition Research. 2015; 3(3):202-205. doi: 10.12691/jfnr-3-3-12


Rutin is the major polyphenol found in buckwheat and can downregulate inflammatory responses in macrophages. However, the underlying mechanism is unclear. Overproduction of nitric oxide (NO) by inducible nitric synthase (iNOS) is closely correlated with inflammation and the pathology of a variety of diseases. It has been reported that rutin inhibited various pro-inflammatory mediators, including cytokine signaling in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells, and suppressed the production of NO and the expression of cyclooxygenase-2 (COX-2) and iNOS protein in LPS-stimulated macrophages. These results suggest that rutin exerts anti-inflammatory effects by suppressing the expression of COX-2 and iNOS in RAW 264.7 macrophage cells. Therefore, rutin can be considered as a functional food for the prevention of various diseases.

anti-inflammation buckwheat macrophage cells nitric oxide rutin

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