Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2015, 3(1), 62-68
DOI: 10.12691/jfnr-3-1-11
Open AccessArticle

High Anti-oxidative and Lipid-lowering Activities of Flavonoid Glycosides-rich Extract from the Leaves of Zanthoxylum bungeanum in Multi-system

Limei Ma1, Ke Li1, Dandan Wei2, Hengyi Xiao2, Hai Niu1, and Wen Huang1,

1Institute for Nanobiomedical Technology and Membrane Biology, and Laboratory of Ethnopharmacology, Regenerative Medicine Research Center, Lab for Aging Research, West China Hospital/West China Medical School, Sichuan University, Chengdu, China

2College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu, China

Pub. Date: January 28, 2015

Cite this paper:
Limei Ma, Ke Li, Dandan Wei, Hengyi Xiao, Hai Niu and Wen Huang. High Anti-oxidative and Lipid-lowering Activities of Flavonoid Glycosides-rich Extract from the Leaves of Zanthoxylum bungeanum in Multi-system. Journal of Food and Nutrition Research. 2015; 3(1):62-68. doi: 10.12691/jfnr-3-1-11

Abstract

Epidemiological studies observed that Zanthoxylum bungeanum leaf, a popular vegetable in China, could interfere progression of cardiovascular diseases, especially hyperlipidemia. In the work, the pharmacological properties of Z.bungeanum leaves extract (ZLE) containing isovitexin, vitexin, hyperoside, rutin, isoquercitrin, foeniculin, trifolin, quercitrin, astragalin, and afzelin were investigated using multi-system such as mice organ tissue, HepG2 cell and apoE-/- mice. ZLE exhibited a stronger activity of scavenging free radicals. ZLE also appeared to inhibit lipid peroxidation of mice organ tissues including the heart, liver, spleen, lung, kidney, brain and pancreas. ZLE could lower lipid accumulation in HepG2 cells induced by free fatty acids (FFAs, an inducer of lipid peroxidation and free radicals production) in a dose-dependent manner. Compared with fenofibrate, a commercial product popularly used in clinical, the treatment of ZLE in apoE-/- mice had a stronger anti-hyperlipidemia without any detectable histopathological damage. This is the first report that ZLE containing high content of flavonoids with satisfying safety could significantly inhibit the development of hyperlipidemia by preventing the oxidative damage induced by free radicals and lipid peroxidation.

Keywords:
Zanthoxylum bungeanum Hyperlipidemia Flavonoid glycosides HepG2 apoE-/- deficient mice

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