Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2014, 2(12), 1037-1041
DOI: 10.12691/jfnr-2-12-27
Open AccessArticle

Protective Effects of Seabuckthorn Seed Oil against Acute Alcoholic-induced Liver Injury in Rats

Meihong Xu1, Na Wang2, Weirui Zhang2 and Junbo Wang1,

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China

2R&D center of TIENS Ltd., Tianjin, PR China

Pub. Date: December 24, 2014

Cite this paper:
Meihong Xu, Na Wang, Weirui Zhang and Junbo Wang. Protective Effects of Seabuckthorn Seed Oil against Acute Alcoholic-induced Liver Injury in Rats. Journal of Food and Nutrition Research. 2014; 2(12):1037-1041. doi: 10.12691/jfnr-2-12-27


The present study examined the protective effects of seabuckthorn seed oil (Hippophae rhamnoidesL seed oil., SBT) on acute alcoholic-induced hepatic damage in male SD rats. Our results showed that oral administration of SBT seed oil at doses of 0.167, 0.333 and 0.500 g/kg for 45 days significantly reduced the changed levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum, and the level of triglyceride (TG) and malondialdehyde (MDA) in liver, which were induced by alcoholic-induced in rats. Moreover, the treatment of SBT seed oil was also found to significantly increase the activities of sglutathione peroxidase (GSH-Px) in liver. Our study found that the optimal dose of SBT seed oil was 0.333 g/kg, as the minimum amount exhibiting the greatest hepatoprotective effects on alcoholic-induced liver injury, which have been supported by the evaluation of the liver histopathology in rats. In conclusion, it has been found the hepatoprotective effect of SBT seed oil at all tested doses.

seabuckthorn seed oil alcoholic-induced liver antioxidation

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