Journal of Food and Nutrition Research
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Journal of Food and Nutrition Research. 2014, 2(11), 850-856
DOI: 10.12691/jfnr-2-11-15
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Hypoglycemic and Hypocholesterolemia Effects of Intragastric Administration of Dried Red Chili Pepper (Capsicum Annum) in Alloxan-Induced Diabetic Male Albino Rats Fed with High-Fat-Diet

Mona Mohamed Abdel Magied1, , Nadia Abdel Rahman Salama1 and Marwa Rashad Ali1

1Department of Food Science, Faculty of Agriculture, Cairo University, Giza, Egypt

Pub. Date: October 29, 2014

Cite this paper:
Mona Mohamed Abdel Magied, Nadia Abdel Rahman Salama and Marwa Rashad Ali. Hypoglycemic and Hypocholesterolemia Effects of Intragastric Administration of Dried Red Chili Pepper (Capsicum Annum) in Alloxan-Induced Diabetic Male Albino Rats Fed with High-Fat-Diet. Journal of Food and Nutrition Research. 2014; 2(11):850-856. doi: 10.12691/jfnr-2-11-15


This study investigated the effect of different drying methods, such as solar drying at 45°C and conventional drying at 60°C on the quality of red chili pepper for two varieties Serrano and Fresno. The conventional drying method had the highest capsaicin content (2.74 and 1.28%) for Serrano and Fresno varieties respectively. The effect of dried red chili pepper at 1 and 2% and the pure capsaicin at 0.015% were studied in experiments using male albino rats containing 20% high fat diet (HFD) rendered diabetic with alloxan injection for 4 weeks. The lowest value of blood serum glucose was with G4 “diabetic group fed HFD + 0.015% capsaicin” that recorded 160 mg/dl. Moreover, serum cholesterol as well as serum triglycerides for the diabetic groups G4 and also G6 that “fed HFD + 2% Serrano red dried chili pepper” were significantly low. The HDL concentration for the groups G4 and G6 were significantly higher than the G3 “diabetic rats fed with HFD”. Feeding the groups of diabetic rats with HFD + 1 or 2% dried red chili pepper or 0.015% capsaicin, the LDL and VLDL levels as well as total lipids were significantly low as compared with control diabetic HFD “G3”.

red chili Capsicum annum drying type 2 diabetes cholesterol high fat diet rats

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