Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2014, 2(11), 806-813
DOI: 10.12691/jfnr-2-11-8
Open AccessArticle

Lifetime Assessment of Dietary Nucleotides Consumption in Sprague-Dawley Rats

Meihong Xu1, 2, Rui Liang1, 2, Qianying Guo1, 2, Shuangjia Wang1, 2, Ming Zhao1, 2, Zhaofeng Zhang1, 2, Junbo Wang1, 2 and Yong Li1, 2,

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China

2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing, PR China

Pub. Date: October 26, 2014

Cite this paper:
Meihong Xu, Rui Liang, Qianying Guo, Shuangjia Wang, Ming Zhao, Zhaofeng Zhang, Junbo Wang and Yong Li. Lifetime Assessment of Dietary Nucleotides Consumption in Sprague-Dawley Rats. Journal of Food and Nutrition Research. 2014; 2(11):806-813. doi: 10.12691/jfnr-2-11-8

Abstract

To assess the long-term toxicity and carcinogenicity of dietary nucleotides (NTs), Sprague-Dawley rats were administered the NTs for life-through with the dose of 0, 0.01%, 0.04%, 0.16% and 0.64%. With the exception of several groups, the results showed no significant differences in weight gain, clinical symptoms data, blood indicators, and Non-neoplastic lesions frequencies. NTs have dramatically increased the food consumption of both sexes (P<0.05). Meanwhile, NTs decreased spontaneous tumor incidence of both sexes, notably the male rats (P<0.05). The occurrence of all malignant and mammary tumors in NTs-treated females was lower than those in controls (P<0.05). In comparison with the control group, the incidence of death from malignant and systemic tumors were obviously decreased in the NTs-treated groups (P<0.01). Moreover, our results showed that a higher percentage of rats in the NTs-treated groups died of non-neoplastic lesions compared with control. In conclusion, dietary nucleotides are not toxic or carcinogenic in rats up to 0.64% for all the life, and 0.64% was an unobservable effect dose.

Keywords:
dietary nucleotides safety lifelong Spontaneous Tumor Incidence Sprague-Dawley rat

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