Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2014, 2(9), 601-607
DOI: 10.12691/jfnr-2-9-12
Open AccessArticle

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Li Nan1, Ouyang Kehui2, Cai Jiaoying1, Yang Wuying1 and Wang Wenjun1,

1Key Lab for Agro-products Processing and Quality Control of Nanchan City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, China

2College of Animal Science and Technonlogy, Jiangxi Agricultural University, Nanchang, China

Pub. Date: September 08, 2014

Cite this paper:
Li Nan, Ouyang Kehui, Cai Jiaoying, Yang Wuying and Wang Wenjun. Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice. Journal of Food and Nutrition Research. 2014; 2(9):601-607. doi: 10.12691/jfnr-2-9-12

Abstract

Aloe flavonoids exhibit various biological activities. The aim of this study was conducted to evaluate antioxidant activity and the hypolipemic mechanism of aloe flavonoids in mice. 80 hyperlipidemic mice were divided into 5 groups, each group was oral administrated with water, 4 mg/kg·BW simvastatin, 100, 200, 300 mg/kg·BW aloe flavonoids per day, respectively. Meanwhile, 16 normal mice were used as blank control, and oral administrated with water per day. After 8 weeks intervention, the concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) in the adipose and liver tissues were evaluated. Also, hormone-sensitive lipase (HSL), peroxisome proliferator-actived receptor gamma (PPAR-γ), adipose triacylglyceride lipase (ATGL), and fatty acid synthase (FAS) genes expressions in the two tissues were detected by Q-PCR. The results showed that aloe flavonoids could decrease the TC, TG levels in the adipose and liver, while the levels of T-AOC, CAT, GSH-Px were significanly increased when compared to the control group. After treating with aloe flavonoids, the gene expressions of HSL, PPARγ and ATGL expression enhanced, but the gene expression of FAS decreased when compared to the control group. In conclusion, our data showed that aloe flavonoids have potent hypolipemic and antioxidant activities.

Keywords:
aloe flavonoids hypolipemic mechanism gene expression mice

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