Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
Open Access
Journal Browser
Journal of Food and Nutrition Research. 2014, 2(6), 330-334
DOI: 10.12691/jfnr-2-6-10
Open AccessArticle

Dietary Fat Intake and Its Relationship with Serum Lipid Profiles in Tehranian Adolescents

Sahar Mohseni-Takalloo1, 2, Parvin Mirmiran3, , Firoozeh Hosseini-Esfahani1 and Fereidoun Azizi4

1Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Faculty of School of Medicine, Bam University of Medical Sciences, Bam, Iran

3Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Pub. Date: June 19, 2014

Cite this paper:
Sahar Mohseni-Takalloo, Parvin Mirmiran, Firoozeh Hosseini-Esfahani and Fereidoun Azizi. Dietary Fat Intake and Its Relationship with Serum Lipid Profiles in Tehranian Adolescents. Journal of Food and Nutrition Research. 2014; 2(6):330-334. doi: 10.12691/jfnr-2-6-10


Dyslipidemia is an important risk factor for cardiovascular disease (CVD) and an important cause of death in adults. Long-term follow-up studies have demonstrated that dietary fat consumption in children and adolescent is one of these risk factors of dyslipidemia in adulthood. The purpose of the current study was to assess the dietary fat intake of Iranian adolescents and their relationship with serum lipid profiles. In this population based cross-sectional study 717 adolescents (391 girls and 326 boys), aged 10 to 19 years, were randomly selected from the fourth phase of Tehran Lipid and Glucose Study (2008-2011). Usual dietary intakes were assessed using valid and reliable food frequency questionnaire and a fasting blood sample was given from all participants to analyze serum lipid profile. Among serum lipid levels, only triglyceride (TG) concentration was higher significantly in boys. In girls, the percent of energy intake from total fat, poly unsaturated fatty acid (PUFA), mono unsaturated fatty acid (MUFA) and trans fatty acids were higher significantly. After adjustment for sex and age, serum levels of TG and HDL-C showed a significant decreasing and increasing trend according to the quartiles of percent of energy intake from PUFA, respectively. No significant difference was observed between other fatty acids and serum lipid profile. In conclusion, although the percent of calorie intake from fat and different types of fatty acids have effect in determining serum lipids levels, but they are not the most important factors for determining the serum lipid profile.

dietary fat intake lipid profile saturated fatty acid polyunsaturated fatty acid trans fatty acid monounsaturated fatty acid

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Haney EM, Huffman LH, Bougatsos C, Freeman M, Steiner RD, Nelson HD, “Screening and treatment for lipid disorders in children and adolescents: systematic evidence review for the US Preventive Services Task Force”, Pediatrics, 120(1), 189-214, 2007.
[2]  Skulas-Ray AC, Kris-Etherton PM, Harris WS, Heuvel JPV, Wagner PR, West SG, “Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia” The American journal of clinical nutrition, 93(2), 243-252, 2011.
[3]  Strong JP, Malcom GT, McMahan CA, Tracy RE, Newman III WP, Herderick EE, et al, “Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study”, Jama, 281(8), 727-735, 1999.
[4]  Valente AM, Newburger JW, Lauer RM, “Hyperlipidemia in children and adolescents”, American heart journal, 142(3), 433-439, 2001.
[5]  Haas G-M, Liepold E, Schwandt P, “Metabolic risk factors, leisure time physical activity, and nutrition in german children and adolescents”, Cholesterol, 2012, 1-3, 2012.
[6]  Dias C, Garg R, Wood L, Garg M, “Saturated fat consumption may not be the main cause of increased blood lipid levels”, Medical hypotheses, 82(2), 187-195, 2013.
[7]  Astrup A, Dyerberg J, Elwood P, Hermansen K, Hu FB, Jakobsen MU, et al, “The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?”, The American journal of clinical nutrition, 93(4), 684-688, 2011.
[8]  Siri-Tarino PW, Sun Q, Hu FB, Krauss RM, “Saturated fat, carbohydrate, and cardiovascular disease”, The American journal of clinical nutrition, 91(3), 502-509, 2010.
[9]  Kelishadi R, Pour MH, Zadegan NS, Kahbazi M, Sadry G, Amani A, et al, “Dietary fat intake and lipid profiles of Iranian adolescents: Isfahan Healthy Heart Program–heart health promotion from childhood”, Preventive medicine, 39(4), 760-766, 2004.
[10]  Kelishadi R, Hashemipour M, Sarraf-Zadegan N, Amiri M, “Trend of atherosclerosis risk factors in children of Isfahan”, Asian cardiovascular and thoracic annals, 9(1), 36-40, 2001.
[11]  Azizi F, Ghanbarian A, Momenan AA, Hadaegh F, Mirmiran P, Hedayati M, et al, “Prevention of non-communicable disease in a population in nutrition transition: Tehran Lipid and Glucose Study phase II”, Trials, 10(5), 1-15, 2009.
[12]  Azizi F, Rahmani M, Emami H, Mirmiran P, Hajipour R, Madjid M, et al, “Cardiovascular risk factors in an Iranian urban population: Tehran lipid and glucose study (phase 1)”, Social and Preventive Medicine, 47(6), 408-426, 2002.
[13]  Hosseini Esfahani F, Asghari G, Mirmiran P, Azizi F, “Reproducibility and relative validity of food group intake in a food frequency questionnaire developed for the Tehran lipid and glucose study”, Journal of Epidemiology, 20(2), 150-158, 2010.
[14]  Mirmiran P, Hosseini Esfahani F, Mehrabi Y, Hedayati M, Azizi F, “Reliability and relative validity of an FFQ for nutrients in the Tehran Lipid and Glucose Study”, Public health nutrition, 13(5), 654-662, 2010.
[15]  Asghari G, Rezazadeh A, Hosseini-Esfahani F, Mehrabi Y, Mirmiran P, Azizi F, “Reliability, comparative validity and stability of dietary patterns derived from an FFQ in the Tehran Lipid and Glucose Study”, British Journal of Nutrition, 108(06), 1109-1117, 2012.
[16]  Ghaffarpour M H-RA, Kianfar H, “The manual for household measures, cooking yields factors and edible portion of food, Tehran, Keshaverzi press, 1999.
[17]  Azar M, Sarkisian E, Food Composition Table of Iran, National Nutrition and Food Research Institute. Shahid Beheshti University Press, Tehran, 1980.
[18]  The Nutrient Data Laboratory. Food Composition Table (FCT), food and nutrition information center, United States Department of Agriculture (USDA). Available from: URL:
[19]  Dorosti A, Tabatabaii M, food composition table, tehran, donyaye taghzieh [in Persian], 2007.
[20]  Friedewald WT, Levy RI, Fredrickson DS, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge”, Clinical chemistry,18(6), 499-502, 1972.
[21]  Kavey R-EW, Daniels SR, Lauer RM, Atkins DL, Hayman LL, Taubert K, “American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood”, Circulation,107(11), 1562-1566, 2003.
[22]  Krauss RM, Siri PW, “Metabolic abnormalities: triglyceride and low-density lipoprotein. Endocrinology and metabolism clinics of North America”, 33(2), 405-415, 2004.
[23]  Brouwer IA, Wanders AJ, Katan MB, “Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans–a quantitative review”, PLoS One, 5(3), e9434, 2010.
[24]  Ghassemi H, Harrison G, Mohammad K, “An accelerated nutrition transition in Iran”, Public health nutrition, 5(1a), 149-155, 2002.
[25]  Mirmiran P, Sherafat-Kazemzadeh R, Farahani SJ, Asghari G, Niroomand M, Momenan AA, et al, “Performance of different definitions of metabolic syndrome for children and adolescents in a 6-year follow-up: Tehran Lipid and Glucose Study (TLGS)”, Diabetes research and clinical practice, 89(3), 327-333, 2010.
[26]  Sahar Mohseni-Takalloo PM, Firoozeh Hosseini-Esfahani, Yadollah Mehrabi, and Fereidoun Azizi, “Metabolic Syndrome and its Association with Healthy Eating Index-2005 in Adolescents: Tehran Lipid and Glucose Study”, Journal of Food and Nutrition Research,2(4), 155-161, 2014.
[27]  Pietiläinen KH, Sysi-Aho M, Rissanen A, Seppänen-Laakso T, Yki-Järvinen H, Kaprio J, et al, “Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects–a monozygotic twin study”, PloS one,2(2), e218, 2007.