Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2022, 10(4), 299-304
DOI: 10.12691/jfnr-10-4-6
Open AccessArticle

Effect of Early Enteral Nutrition on Traumatic Brain Injury and Complications

Qin Xie1, Xiao-Yan Zhang1, Xiao-Bing Sun1, Bei-Bei Chen1 and Xiao-Quan Huang1,

1Department of Intensive Care medicine, Affiliated Nantong Rehabilitation Hospital of Nantong University (The Second People's Hospital of Nantong), Nangtong, Jiangsu Province, China

Pub. Date: April 15, 2022

Cite this paper:
Qin Xie, Xiao-Yan Zhang, Xiao-Bing Sun, Bei-Bei Chen and Xiao-Quan Huang. Effect of Early Enteral Nutrition on Traumatic Brain Injury and Complications. Journal of Food and Nutrition Research. 2022; 10(4):299-304. doi: 10.12691/jfnr-10-4-6


Background Early and adequate nutrition plays a crucial role in the prognosis and occurrence of complications in patients with traumatic brain injury (TBI). We aimed to explore effect of early enteral nutrition (EN) on TBI and its complications. Methods: 200 eligible patients who were with TBI and received neurosurgery were recruited and randomly assigned to control group (n=100) or EN group (n=100). The controls were given conventionally intravenous nutrition, while, apart from conventional nutrition, patients in EN group were additionally given EN via nasal feeding 24 h post neurosurgery for 7-14 days. The clinical outcomes as reflected by Glasgow Coma Score (GCS), complications, and the level of inflammatory factors as well as blood beta-amyloid protein (Aβ) were analyzed. Results: Patients with TBI underwent EN had a higher GCSs than the controls (P<0.05). Higher total incidence of complications, including pulmonary infection and intracranial infection, in control group, was observed (P<0.05). EN exerted a striking improvement in nutritional status. Logistical regression analysis found EN treatment was a protective factor for the occurrence of complications. Dramatically, EN treatment significantly made a remarkable reduction in blood level of inflammatory factors as well as Aβ (P<0.05 for all). Conclusion: Our study concluded EN is conducive to improve the clinical outcomes and to decrease the incidence of complications.

early enteral traumatic brain injury clinical outcomes complication glasgow coma score inflammatory factors

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