Effects of a Fermented Grape Combined with Specified Fruits and Vegetables or Their Extracts on Anti-aging and Anti-inflammatory Status: A Randomized Controlled Clinical Trial

Yung-Kai Lin^{1, 2}, Yu-Yu Kao³, Cheng Liu⁴, Chia-Hua Liang⁵, Yung-Hsiang Lin⁶, Wei-Chun Hu⁶ and Chi-Fu Chiang^6,

¹Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung, Taiwan

²Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan;Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan

³Shanghai Daerwei Biotechnology R&D Co., Ltd., Shanghai, China

⁴Department of Health and Beauty, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan

⁵Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan

⁶Research & Design Center, TCI CO., Ltd., Taipei, Taiwan

Cite this paper:
Yung-Kai Lin, Yu-Yu Kao, Cheng Liu, Chia-Hua Liang, Yung-Hsiang Lin, Wei-Chun Hu and Chi-Fu Chiang. Effects of a Fermented Grape Combined with Specified Fruits and Vegetables or Their Extracts on Anti-aging and Anti-inflammatory Status: A Randomized Controlled Clinical Trial. Journal of Food and Nutrition Research. 2021; 9(6):292-296. doi: 10.12691/jfnr-9-6-4

Abstract

Vegetables and fruits had antioxidant capacity. Fermented grapes had a higher content of anthocyanins and flavonoids, and reduced skin wrinkles. There were not more clinical studies on whether fermented grapes with fruit and vegetable extracts had anti-aging and anti-inflammatory activities. The current study used fermented grapes beverages made from fermented grapes combined with fruit and vegetable extracts to explore anti-aging and anti-inflammatory. 60 subjects were recruited and divided into a placebo and another fermented grape drinks group. The subjects drank 50 ml , 1 bottle a day for 8 week. After drinking for 8 weeks, a skin test and blood inflammatory factor analysis were performed. Compared to the placebo group, skin brightness, moisture, elasticity was significantly increased by 3.6%, 4.9%, 5.4%, respectively. Fermented grape drinks decreased skin spots, and wrinkles by 7.0%, and 19.0%, respectively. TNF-¦Á (Tumor Necrosis Factor) and IL-6 (Interleukin-6) expression were decreased, also, as a function of fermented grape drinks intakes. This study indicated that fermented grapes combined with fruit and vegetable extracts can significantly improve the brightness, moisture, elasticity, wrinkles, pores, and decrease TNF-¦Á and IL-6 expression.

Keywords:
fruit vegetable grapes inflammation skin aging

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