Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2021, 9(6), 292-296
DOI: 10.12691/jfnr-9-6-4
Open AccessArticle

Effects of a Fermented Grape Combined with Specified Fruits and Vegetables or Their Extracts on Anti-aging and Anti-inflammatory Status: A Randomized Controlled Clinical Trial

Yung-Kai Lin1, 2, Yu-Yu Kao3, Cheng Liu4, Chia-Hua Liang5, Yung-Hsiang Lin6, Wei-Chun Hu6 and Chi-Fu Chiang6,

1Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung, Taiwan

2Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan;Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan

3Shanghai Daerwei Biotechnology R&D Co., Ltd., Shanghai, China

4Department of Health and Beauty, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan

5Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan

6Research & Design Center, TCI CO., Ltd., Taipei, Taiwan

Pub. Date: June 28, 2021

Cite this paper:
Yung-Kai Lin, Yu-Yu Kao, Cheng Liu, Chia-Hua Liang, Yung-Hsiang Lin, Wei-Chun Hu and Chi-Fu Chiang. Effects of a Fermented Grape Combined with Specified Fruits and Vegetables or Their Extracts on Anti-aging and Anti-inflammatory Status: A Randomized Controlled Clinical Trial. Journal of Food and Nutrition Research. 2021; 9(6):292-296. doi: 10.12691/jfnr-9-6-4


Vegetables and fruits had antioxidant capacity. Fermented grapes had a higher content of anthocyanins and flavonoids, and reduced skin wrinkles. There were not more clinical studies on whether fermented grapes with fruit and vegetable extracts had anti-aging and anti-inflammatory activities. The current study used fermented grapes beverages made from fermented grapes combined with fruit and vegetable extracts to explore anti-aging and anti-inflammatory. 60 subjects were recruited and divided into a placebo and another fermented grape drinks group. The subjects drank 50 ml , 1 bottle a day for 8 week. After drinking for 8 weeks, a skin test and blood inflammatory factor analysis were performed. Compared to the placebo group, skin brightness, moisture, elasticity was significantly increased by 3.6%, 4.9%, 5.4%, respectively. Fermented grape drinks decreased skin spots, and wrinkles by 7.0%, and 19.0%, respectively. TNF-¦Á (Tumor Necrosis Factor) and IL-6 (Interleukin-6) expression were decreased, also, as a function of fermented grape drinks intakes. This study indicated that fermented grapes combined with fruit and vegetable extracts can significantly improve the brightness, moisture, elasticity, wrinkles, pores, and decrease TNF-¦Á and IL-6 expression.

fruit vegetable grapes inflammation skin aging

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