Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2021, 9(2), 73-78
DOI: 10.12691/jfnr-9-2-3
Open AccessArticle

Antioxidant Capacity and Immune Regulation Properties of a Herbal Mixture Including Sparassis crispa, Aureobasidium pullulan, and Ganoderma lucidum

Yung-Kai Lin1, Wei-Chun Hu2 and Chi-Fu Chiang3,

1Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung, Taiwan

2Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan

3Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan

Pub. Date: February 05, 2021

Cite this paper:
Yung-Kai Lin, Wei-Chun Hu and Chi-Fu Chiang. Antioxidant Capacity and Immune Regulation Properties of a Herbal Mixture Including Sparassis crispa, Aureobasidium pullulan, and Ganoderma lucidum. Journal of Food and Nutrition Research. 2021; 9(2):73-78. doi: 10.12691/jfnr-9-2-3


Many Chinese herbal medicines have been proven to have anti-inflammatory effects. Among them, edible and medicinal mushrooms are rich in a variety of physiologically active ingredients, which can enhance immunity and are good materials for the development of health foods. This article aims to investigate the beneficial effects of SOD Light, a herbal formula consisting of Sparassis crispa, Aureobasidium pullulan, and Ganoderma lucidum, on anti-inflammation, antioxidant, and immune-modulation. SOD Light was able to inhibit ROS expression level and boost the SOD activity in PBMCs by 11% and 43.8%, respectively, as compared with the control group, and the significant improvement effect of the phagocytic activity of neutrophils was exhibited. Moreover, SOD Light also significantly enhanced the expression of the lymphocyte development-associated and adaptive immune-related genes (i.e., CD134, CD26, CD96, CD247, and IL-16). This study successfully unveils that the combination of S. crispa, A. pullulans, and G. lucidum was available for anti-oxidation, cytokines production, enhancement of T cell activation, and lymphocyte development in PBMCs, which implies that SOD Light are beneficial for immune modulation.

antioxidant Aureobasidium pullulan Ganoderma lucidum Sparassis crispa immune modulation

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