Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2020, 8(7), 378-381
DOI: 10.12691/jfnr-8-7-9
Open AccessArticle

Antoxidative Activities and Liver-protective Effects of Myelophycus simplex Extract

Sang Jae Kwak1 and Hyun Woo Kang1,

1Department of Korean Food & Culinary Arts, Youngsan University, Busan, 48015, Korea

Pub. Date: August 05, 2020

Cite this paper:
Sang Jae Kwak and Hyun Woo Kang. Antoxidative Activities and Liver-protective Effects of Myelophycus simplex Extract. Journal of Food and Nutrition Research. 2020; 8(7):378-381. doi: 10.12691/jfnr-8-7-9


The free radical scavenging activity of extracts prepared from Myelophycus simplex was evaluated by using an ESR spectrometer. For this study, Myelophycus simplex was 70% ethanol extraction was performed. Myelophycus simplex extracts scavenged DPPH, hydroxyl, superoxide, and alkyl radicals. Especially, the extracts exhibited the highest scavenging activity on hydroxyl radical, which is deemed of the strongest radical. In addition, we also evaluated the protective effects of Myelophycus simplex extract on 3.5% alcohol-induced damage (oxidative stress) in normal liver cells. The Myelophycus simplex extract inhibited productions of reactive oxygen species (ROS), and cell death against alcohol-induced liver cell damage. It was presumed that the Myelophycus simplex extract was involved in regulation of apoptosis-related pathway in the cell environments. These results indicate that Myelophycus simplex extract possess antioxidative activity on liver cells.

Myelophycus simplex antioxidant free radical liver cells flow cytometer

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[1]  Kim, S.Y., Ryu, K.S., Lee, W.C., Ku, H.O., Lee, H.S., and Lee, K.R., "Hypoglycemic effect of mulberry leaves with anaerobic treatment in alloxan-induced diabetic mice" Korean J Pharmacogn 30, 123-129. 1999.
[2]  Cho, Y.J., Ju, I.S., Chun, S.S., An, B.J., Kim, J.H., Kim, M.U., and Kwon, O.J., "Screening of biological activities of extracts from Rhododendron mucronulatum Turcz. Flowers" J Korean Soc Food Sci Nutr 37, 276-281. 2008
[3]  Huang, M.T., Ho, C.T., and Lee, C.Y., "Phenolic compounds in food. In Phenolic Compounds in Food and Their Effects on Health II" Maple Press, New York, NY, USA. Vol 99, p 2-7. 1992.
[4]  Lee, S.J., Sung, N.J., Jeong, H.G., Shin, J.H., Chung, Y.C., and Seo, J.K., "Antioxidant activities of methanol extracts from Prunella vulgaris" J Korean Soc Food Sci Nutr 37, 1535-1541. 2008.
[5]  Lee, S.Y., Hwang, E.J., Kim, G.H., Choi, Y.B., Lim, C.Y., and Kim, S.M., "Antifungal and antioxidant activities of extracts from leaves and flowers of Camella japonica L." Korean J Medicinal Crop Sci 13, 93-100. 2005.
[6]  Lee, S.M., Son, E.S., Oh, S.S., and Han, D.S., "Contents of total flavonoid and biological activities of edible plants" Korean J Dietary Culture 16, 504-514. 2001.
[7]  Lee, B.B., Chun, J.H., Lee, S.H., Park, H.R., Kim, J.M., Park, E.J., and Lee, S.C., "Antioxidative and antigenotoxic activity of extracts from Rhododendron mucromulatum Turcz. Flowers" J Korean Soc Food Sci Nutr 36, 1628-1632. 2007.
[8]  Oh, B. G., Lee, J. W., and Lee, H. B., "A summer marine benthic algal flora and community of Uninhabited islands in Haenamgun, southern coast of Korea" J Kor Fish Soc 35, 57-63. 2002.
[9]  Noda, H., Amano, H., Arshima, K., Hashimoto, S., and Nisizawa, W., "Studies on the antitumor activity of marine algae" Bull Japan Soc Sci Fish 55, 1259-1264. 1989.
[10]  Schwartsmann, G., Brondani da Rocha, A., Berlinck, R. G., and Jimeno, J., "Marine organisms as a source of new anticancer agents" Lancet Oncol 2, 221-225. 2001.
[11]  Shi, D. B., Han, E. H., and Park, S. S., "Cytoprotective effects of phaeophyta extracts from the coast of Jeju island in HT-22 mouse neuronal cells" J Kor Soc Food Sci Nutr 43, 224-230. 2014.
[12]  Lee, S.J., Kim, Y.S., Hwang, J.W., Kim, E.K., Moon, S.H., Jeon, B.T., Jeon, Y.J., Kim, J.M., and Park, P.J., "Purification and characterization of a novel antioxidative peptide from duck skin by-produc ts that protects liver against oxidative damage", Food Res Int 49, 285-295. 2012.
[13]  Hertog, M.G.L., Hollman, P.C.H., Katan, M.B., and Kromhout, D., "Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands" Nutr Cancer 20, 21-29. 1993.
[14]  Oktay, M., Glin, I., and Kfreviolu, I., "Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts" LWT-Food Sci Technol 36, 263-271. 2003.
[15]  Glin, I., Bykokurolu, M.E., and Kfreviolu, I., "Metal chelating and hydrogen peroxide scavenging effects of melatonin" J Pineal Res 34, 278-281. 2003.
[16]  Cashman, J.R., "Monoamine oxidase and flavin-containing monooxygenases" In Biotransformation, Guengerich, F. P, Ed. Elsevier, New York p69-96. 1997.