Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
Open Access
Journal Browser
Go
Journal of Food and Nutrition Research. 2020, 8(4), 189-194
DOI: 10.12691/jfnr-8-4-5
Open AccessArticle

Amazonian Fruits Antioxidant Capsules: Quality Control and Stability

Adele Salomão-Oliveira1, , Grazielle da Costa Pontes2, Kátia Solange Cardoso Rodrigues dos Santos3, Emerson Silva Lima3 and Rosany Piccolotto Carvalho4

1Multi-Institutional Post-Graduate Biotechnology Program, Universidade Federal do Amazonas (UFAM), Manaus, AM, Brazil

2Department of Research, Society and Health, Instituto Nacional de Pesquisas da Amazônia (INPA), Manaus-AM, Brazil

3Pharmaceutical Sciences Department, Universidade Federal do Amazonas (UFAM), Manaus, AM, Brazil

4Physiological Science Department, Universidade Federal do Amazonas (UFAM), Manaus, AM, Brazil

Pub. Date: May 24, 2020

Cite this paper:
Adele Salomão-Oliveira, Grazielle da Costa Pontes, Kátia Solange Cardoso Rodrigues dos Santos, Emerson Silva Lima and Rosany Piccolotto Carvalho. Amazonian Fruits Antioxidant Capsules: Quality Control and Stability. Journal of Food and Nutrition Research. 2020; 8(4):189-194. doi: 10.12691/jfnr-8-4-5

Abstract

The productive diversification in the Amazonian region is favored by the abundance and availability of its natural products and, biotechnology has stood out as an alternative in the innovative process of quality control and sustainable economic development. Based on this, one expects that bioproducts from this biome might favor the treatment of noncommunicable chronic diseases. The methods to be used for controlling the quality of the bioactive and microbiological compounds being encapsulated are operations necessary to guarantee the safety in the treatment with Amazon fruits consumed by individuals. Ascorbic acids and phenolic compounds analyses were carried out through HPLC and spectrometry, respectively. The present study has also ascertained the formulation to bear free radical scavenging activity in the DPPH tests. Thus, the methods used for controlling the quality of n.00 capsules and the Amazonian fruits formulation’s bioactive content corresponded to the specifications included in the American Pharmacopoeia. Therefore, the differentiated quality control due to the large-scale production and the quantity of bioactive compounds originating from more than one Amazonian fruit points to the pharmaceutical specialties according to the international standards of quality of the health benefits to be made available to the society with the desired therapeutic effect, and characteristics appropriate for oral administration. The manipulated capsules were stored at 5 ºC and the bioactive compounds stability was considered satisfactory in the preservation of their assets for 5 months with the produced capsules quality control guaranteed.

Keywords:
biotechnology capsules antioxidant stability amazonian fruits quality control

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Langley, P.C., Pergolizzi, J.V., Taylor, R., Ridgway, C., “Antioxidant and Associated Capacities of Camu Camu (Myrciaria dubia): A Systematic Review”, The Journal of Alternative and Complementary Medicine, 21(1). 8-14. 2015.
 
[2]  Leão, A.L.M., Santos, L.C., “Consumo de micronutrientes e excesso de peso: existe relação?”, Revista Brasileira de Epidemiologia, 15(1). 85-95. 2012.
 
[3]  Yonekura, L., Martins, C.A., Sampaio, G.R., Monteiro, M.P., César, L.A.M., Mioto, B. M., Mori, C.S., Mendes, T.M.N., Ribeiro, M.L., Arçari, D.P., Torres, E.A.F.S., “ Bioavailability of catechins from guaraná (Paullinia cupana) and its effect on antioxidant enzymes and other oxidative stress markers in healthy human subjects”, Food & Function, 7.2970-2978.2016.
 
[4]  Salomão-Oliveira, A., Lima, E.S.L., Marinho, H.A., Carvalho, R.P., “Benefits and Effectiveness of Using Paullinia cupana: A Review Article”, Journal of Food and Nutrition Research, 6(8). 497-503.2018.
 
[5]  Salomão-Oliveira, A., Costa, S.S., Marinho, H.A., “Metabolic syndrome: Intake of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)”, International Journal of Food Science and Nutrition, 3(6). 5-13. 2018.
 
[6]  NCHS. National Center for Health Statistics. Health, United States, 2018. Hyattsville, MD. 2019.
 
[7]  Brasil. Ministério da Saúde. Pesquisa Nacional de Saúde (PNS), Acesso e utilização dos serviços de saúde, acidentes e violências, grandes regiões e unidades da federação. IBGE, Coordenação de Trabalho e Rendimento, Brazil, Rio de Janeiro 100 p. 2015.
 
[8]  Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Análise de Situação de Saúde, Plano de ações estratégicas para o enfrentamento das doenças crônicas não transmissíveis (DCNT) no Brazil 2011-2022, 2011.
 
[9]  NCEP-ATP III. Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evalution, and Tratment of Hight Blood Cholesterol in Adults (Adult Treatment Panel III), “Final Report, National Cholesterol Education Program, National Heart, Lung and Blood Institute, National Institute of Health”, NIH Publication, 2.5215.2002.
 
[10]  SBC. Sociedade Brasileira de Cardiologia, “Arquivos Brasileiros de Cardiologia”, V Diretriz da Sociedade Brasileira de Cardiologia sobre Tratamento do Infarto Agudo do Miocárdio com Supradesnível do Segmento ST, 105(2). 1-81.2015.
 
[11]  Brasil. Ministério da Saúde. Agência Nacional de Vigilância Sanitária, Formulário Nacional da Farmacopeia Brasileira, Brazil. 2. ed., 2012.
 
[12]  Rufino, M.S.M., Alves, R.E., Brito, E.S., Perez-Jimenez, J., Saura-Calixto, F., Mancini, F. J., “Bioactive compounds and antioxidante capacitiesof 18 non-tradicional tropical fruits from Brazil”, Food Chemistry, 121. 996-1002. 2010.
 
[13]  Sveum, W.H., Moberg, L.J., Rude, R.A., Frank, J.F., “Microbiological monitoring of the food processing environment”. In: Vanderzant C, Splittstoesser DF, Speck ML (Eds.), Compendium of methods for the microbiological examination of foods, 3. ed. Washington: APHA chapter, 3.51-74.1992.
 
[14]  ANVISA. Agência Nacional de Vigilância Sanitária, Resolução RDC nº 12, de 02 de janeiro, Brazil. 2001.
 
[15]  ICMS. Internation commission on microbiological specifications for foods, Their significance and methods of enumeration, 2. ed. University of Toronto. 2006.
 
[16]  IAL. Instituto Adolfo Lutz. Normas Analíticas do Instituto Adolfo Lutz, 4. ed., São Paulo. Brazil. 2008.
 
[17]  AOAC. Association of Official Analytical Chemistry, Official methods of Analysis of the Association of Official Analytical Chemistry, 18. ed., Gaithersburg, MD, International, 2005.
 
[18]  TBCA-USP. Tabela de Composição Química dos Alimentos. Universidade Federal de São Paulo. Brazil, versão 3. 2014.
 
[19]  Bonoli, M., Verardo, V., Marconi, E., Caboni, M. F., “Antioxidant phenols in barley (Hordeum vulgare L.) flour: comparative spectrophotometric study among extraction methods of free and bound phenolic compounds”, Journal of Agricultural and Food Chemistry, 52(16). 5195-5200. 2004.
 
[20]  Campos, F.M., Ribeiro, S.M.R., Della Lucia, C.M., Stringheta, P.C., Pinheiro-Sant’Ana, H.M., “Optimization of methodology to analyze ascorbic acid and dehydroascorbic acid in vegetables”, Química Nova, 32(1). 87-91.2009.
 
[21]  Sousa, C.M.M., Silva, H.R., Vieira-Jr, G.M., Ayres, M.C.C., Costa, C.L.S., Araújo, D.S.; Cavalcante, L. C. D.; Barros, E. D. S.; Araújo, P. B.M.; Brandão, M. S.; Chaves, M. H., “Total phenolics and antioxidant activity of five medicinal plants”, Química Nova, 30(2). 351-355. 2007.
 
[22]  Salomão-Oliveira, A., Costa, S.S., Dos Santos, K.S.C.R., Souza, T.P., Marinho, H.A., “Ascorbic acid from lyophilized camu-camu fruit: stability and quality control of hard capsules”, Rev Ciênc Farm Básica Apl, 37(1). 1-7. 2016.
 
[23]  The United States Pharmacopeia. USP-NF 37 United States Pharmacopeia Convention. 42. ed. 2019.
 
[24]  ANVISA. Agência Nacional de Vigilância Sanitária. Farmacopeia Brasileira. 5. ed. Brasília: Ministério da Saúde, 2. 524. 2010.
 
[25]  Yuyama, K.A., Valente, J.P. Camu-camu. 1. ed., PR: CRV, Curitiba, Brazil.2011.
 
[26]  Salomão-Oliveira, A., Marinho, H.A., “Bioactive Compounds and Antioxidant Activity of Camu-Camu (Myrciaria dubia (Kunth) Mc Vaugh) Grown on a Non-Flooded Land Ecosystem”, Journal of Food and Nutrition Research, 5(12). 941-946. 2017.
 
[27]  ANVISA. Agência Nacional de Vigilância Sanitária. Resolução- RDC Nº 54, de 12 de novembro de 2012. Dispõe sobre o Regulamento Técnico sobre Informação Nutricional Complementar. 2012.