Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2019, 7(12), 827-835
DOI: 10.12691/jfnr-7-12-3
Open AccessArticle

The Radioprotective and Anticancer Effects of Banana Peels Extract on Male Mice

Amaal M. Kamal1, Mervat S. Taha1 and Amr M. Mousa1,

1Department of biological Applications, Nuclear Research Center, Atomic Energy Authority, Egypt

Pub. Date: December 13, 2019

Cite this paper:
Amaal M. Kamal, Mervat S. Taha and Amr M. Mousa. The Radioprotective and Anticancer Effects of Banana Peels Extract on Male Mice. Journal of Food and Nutrition Research. 2019; 7(12):827-835. doi: 10.12691/jfnr-7-12-3

Abstract

This study was performed to evaluate the radioprotective and anticancer effect of banana peels extract on male mice. Sixty male mice weighted 18- were used, the animals divided equally into six groups as follow first group act as normal , second group (Tumor control) implanted with Ehrlich tumor, third group ,irradiated group exposed to single dose of 3.0 GY of gamma rays, fourth group (banana peels extract 300 mg/kg/day orally for 3weeks, fifth group (tumor implanted + banana peels extract 300 mg/kg/day orally for 3weeks, sixth group (irradiated with dose 3.0 GY gamma+ 300 mg/kg/day for 3 weeks). At the end of experiment mice were sacrificed by anesthesia and the blood were collected to evaluate biochemical parameters (Complete Blood Count (CBC), Carcino embryonic antigen,(), Malonaldehyde (), Molecular study, electrophoretic assayed. The results showed that banana peels extract ameliorate the alteration in in irradiated and tumor group, and significantly decrease p≤0.05 the elevation of Carcino embryonic antigen in tumor implanted group, significantly decrease the elevation of Malonaldehyde in tumor implanted group and irradiated group. According to protein fractions and western blotting data it could be concluded that, addition banana peels extract consider a crucial impact for Irradiation dose which cleared through huge increase of Polymorphism % for addition banana peels extract (20%) comparing with to Irradiation treatment which didn’t reflect polymorphism. Furthermore, noticeable stimulation for P53 expression level was detected for applying banana peels extract and Irradiation as Compound dosage.

Keywords:
banana peels extract antitumor irradiation protective and mice

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