Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
Open Access
Journal Browser
Go
Journal of Food and Nutrition Research. 2019, 7(6), 458-464
DOI: 10.12691/jfnr-7-6-8
Open AccessArticle

In Vivo Evaluation of Tectoridin from Puerariae flos on Anti-alcoholism Property in Rats

Qiao-Yun Zhang1, Wen Zheng1, Shahzor Gul Khaskheli2 and Wen Huang1,

1College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China

2Institute of Food Sciences and Technology, Sindh Agriculture University, Tandojam, Pakistan

Pub. Date: June 17, 2019

Cite this paper:
Qiao-Yun Zhang, Wen Zheng, Shahzor Gul Khaskheli and Wen Huang. In Vivo Evaluation of Tectoridin from Puerariae flos on Anti-alcoholism Property in Rats. Journal of Food and Nutrition Research. 2019; 7(6):458-464. doi: 10.12691/jfnr-7-6-8

Abstract

Puerariae Flos have developed into one of the improved selling herbal medicines for healing of diseases such as alcohol intoxication and liver injury in China and Japan. Herbal medicines with the multi-targeted and less toxic characteristic have fascinated more attention in the prevention of Alcoholic liver disease ALD. The aim of this study was to investigate the effects of tectorigenin on chemically induced liver fibrosis in rats, Chinese medicine is considered to be an imperative and substitute approach. Tectoridin, naturally extracted from pueraria thunbergiana flos, is commercially acclaimed for its anti-alcoholism function. Furthermore, it was analyzed the effects of tectoridin on sobering the rats up, and to explore the mechanisms of tectoridin from Pueraria thunbergiana Flos sobering the roots up by decreasing the alcohol content, ADH activity in a rat model and the best anti-alcoholism properties among tectoridin, tectorigenin and tectorigenin sodium sulfonate. Acute alcohol poisoning experiment models of rats were set up to evaluate the blood alcohol content in blood and ADH activity in liver. Results showed that tectoridin demonstrated the anti-alcoholism property and a dose of 75mg·kg-1·bw tectoridin showed the strongest clearance rate of ethanol. The comparison of the anti-alcoholism capacity were as follows: tectorigenin sodium sulfonate (52.86%) was better than tectoridin (47.31%) (P < 0.01) and tectoridin was better than tectorigenin (43.67%) (P < 0.01).

Keywords:
Pueraria Flos extraction tectorigenin acute alcohol poisoning alcohol content ADH

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Urashima, S., Tsutsumi, M., Shimanaka, K. Histochemical study of hyaluronate in alcohol liver disease. Alcoholism-clinical and Experimental Research 23, 568-608. 2009.
 
[2]  Testino, G. Alcoholic diseases in hepato-gastroenterology: a point of view. Hepato- gastroenterology 55, 371-377. 2008.
 
[3]  Crabb, D.W. Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic live disease. Prog Liver Dis 13, 151-172. 1995.
 
[4]  Kim, C., Shin, S., Ha, H., Kim, J.M. Study of substance changes in flowers of Pueraria thunbergiana Benth during storage. Archives of Pharmacal Research 26, 210-213. 2003.
 
[5]  Bilbao-Sainz et al “Hydration kinetics of dried apple as affected by drying condion Journal of Food Engineering. 68, 369-376. 2005.
 
[6]  Akkemik, E., Sellturk, M., Ozgeris,F.B. In vitro effects of some drugs on human erythrocyte glutathione reductase. Turkish Journal of Medical Sciences 41, 235-241. 2011.
 
[7]  Diesen, D.L., Kuo, P.C. Nitric oxide and redox regulation in the liver: Part II. Redox biology in pathologic hepatoeytes and implications for Intervention. Journal of Surgical Research 167, 96-112. 2011.
 
[8]  Shin, J., Bae, E.A., Lee, Y.C., Ma, J.Y., Kim, D.H. Estrogenic effect of main components kakkalide and tectoridin of puerariae flos and their metabolites. Biological & Pharmaceutical Bulletin 29, 1202-1206. 2006.
 
[9]  Keung, W.M., Vallee, B.L. Kudzu root: an ancient Chinese source of modern antidipsortopic agents. Phytochemistry 47, 499-506. 1998.
 
[10]  Lee, K.T., Sohn, C., Kim, D.H., Choi, J.W., Kwon, S.H., Park, H.J. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-induced diabetic rat and their antioxidant activity in xitro. Arch Pharm Res 23, 461-466. 2000.
 
[11]  Lee, K.T., Sohn, I.C., Kim, Y.K., Choi, J.H., Choi, J.W., Park, H.J., Itoh, Y., Miyamoto, K.I. Tectorigenin, an isoflavone of Pueraria thunbergiana BENTH., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. Biological and Pharmaceutical Bulletin 24, 1117-1121. 2001.
 
[12]  Park, H.J., Park, J.H., Moon, J.O., Lee, K.T., Jung, W.T., Oh, S.R., Lee, H.K. Isoflavone glysides from the flowers of Pueraria Thurbergiana. Phytochemistry 51, 147-151. 1999.
 
[13]  Park, K.Y., Jung, G.O., Choi, J., Lee, K.T., Park, H.J. Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana. Archives of Pharmacal Research 25, 320-324. 2002.
 
[14]  King, R.A., Broadbent, J.L., Head, R.J. Absorption and excretion of the soy isoflavone genistein in rats. Journal of Nutrition 126, 176-182. 1996.
 
[15]  Izumi, T., Piskula, M.K., Obata, A., Tobe, K., Satito, M. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. Journal of Nutrition 130, 1695-1699. 2000.
 
[16]  Bae, E.A., Han, M.J., Lee, K.T., Choi, J.W., Park, H.J., Kim, D.H. Metabolism of 6”-O-xylosyltectoridin and tectoridin by human intestinal bacteria and their hypoglycemic and in vitro cytotoxic activities. Biological & Pharmaceutical Bulletin 22, 1314-1318. 1999.
 
[17]  Park, E.K., Shin, Y.W., Lee, H.U., Lee, C.S., Kim, D.H. Passive cutaneous anaphylaxis—inhibitory action of tectorigenin, a metabolite of tectoridin by intestinal microflora. Biological & Pharmaceutical Bulletin 27, 1099-1102. 2004.
 
[18]  Nohara, T., Kinjo, Y., Nakajima, K. The new isoflavoid of Pueraria lobata. Kokai Tokkyo Koho 694, 17-07. 2000.
 
[19]  Kang, K.A., Lee, K.H., Chae, S., Zhang, R., Jung, M.S., Kim, S.Y., Kim, H.S., Kim, D.H., Hyun, J. V.V. Cytoprotective effect of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, on oxidative stress induced by hydrogen peroxide. European journal of pharmacology 519, 16-23. 2005.
 
[20]  Tsuchihashi, R., Kodera, M., Sakamoto, S., Nakajima, Yamazaki T., Niiho, Y., Nohara, T., Kinjo, J. Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains. Journal of Natural Medicines 63, 254-260. 2009.
 
[21]  Kang, K.A., Zhang, R., Piao, M.J. Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect. Bioorganic and Medicinal Chemistry 16, 1133-1141. 2008.
 
[22]  Zhang, Y.D., Huang, W. Study on isolation, purifieation, identifieation of structure of the isoflavones from puerariae flos. Processing and Storage of Agricultural Products 321, 105-274. 2009.
 
[23]  Lee, K.T., Sohn, C., Kim, Y.K., Choi, J.H., Choi, J.W., Park, H.J., Itoh, Y., Miyamoto, K. Tectorigenin, an isoflavone of Pueraria thunbergiana Benth., induces differentiation and apoptosis in human promyelocytic. Biological & Pharmaceutical Bulletin 24, 1117-1121. 2001.
 
[24]  Mishra, A., Paul, S., Swarnakar, S. Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice. Biochimie 93, 854-866. 2011.
 
[25]  Mattef, K., Laissue, J.A. Copper/zinc and manganese superoxide dismutases in alcoholic liver disease: Immunohistochemical quantitation. Histology and Histopathology 11, 899-907. 2005.
 
[26]  Nuviala, R.J., Roda, L., Lapieza, M.G. Serum enzymes activities at rest and after a marathon race. Journal of Sports Medicine and Physical Fitness 32, 180-186. 1992.
 
[27]  Lee, K.T., Sohn, C., Kim, D.H., Choi, J.W., Kwon, S.H., Park, H.J. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-induced diabetic rat and their antioxidant activity in vitro. Archives of Pharmacal Research 23, 461-466. 2000.
 
[28]  Kim, C., Shin, S., Ha, H., Kim, J.M. Study of substance changes in flowers of pueraria thunbergiana (Benth.) during storage. Archives of pharmacal research 26, 210-213. 2003.
 
[29]  Albano, E. Free radical mechanisms in immune reactions associated with alcoholic disesase. Free Radical Biology and Medicine 32, 110-114. 2002.
 
[30]  Crabb, D.W. Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic live disease. Prog Liver Dis 13, 151-172. 1995.
 
[31]  Sadzuka, Y., Sugiyama, T., Nagamine, M. Efficacy of theanine is conneeted with theanine metabolism by any enzyme, not only drug metabolizing enzymes. Food and Chemical Toxicology 44, 286-292. 2006.
 
[32]  Guo, H., He, H., Han, Y., Huang, W.H., Zhang, X.O. Effect of corn peptides on alcohol dehydrogenase activity in live of mice after drinking and its anti-alcohol mechanism. Food Science 11, 0265-05. 2011.
 
[33]  Szuster-Ciesielska, A., Daniluk, J., Kandefer-Szerszen, M. Oxidative stress in the blood of patients with alcohol-related liver cirrhosis. Med Sci Monit 8, 419-24. 2002.
 
[34]  Seo, H.J., Jeong, K.S., Lee, M.K. Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. Life Sciences 73, 933-946. 2003.
 
[35]  Bruha, R., Dvorak, K., Petrtyl, J. Alcoholic liver disease. Word Journal of Hepatology 43, 81-90. 2012.
 
[36]  Testino, G., Burra, P., Bonino, F., Piani, F., Sumberaz, A., Peressutti, R., Castiglione, A.G., Patussi, V., Fanucchi, T. Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement. Word Journal of Hepatology 2040, 14642-14651. 2014.
 
[37]  Thkada, A., TSutsuxni, M.D. Iagnostic-criteria for alcoholic liver-disease. International Hepatology Communications 3, 63-69. 2005.
 
[38]  Hwang, C., Sinskey, A.J., Lodish, H.F. Oxidized redox state of glutathione in the endoplasmic-reticulum. Science 257, 1496-1502. 2012.
 
[39]  Han, Y.O., Han, M.J., Park, S.H., Kim, D.H. Protective effects of kakkalide from Flos puerariae in ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora. Yakugaku zasshi 109(6), 424-431. 1989.
 
[40]  Wang, L.Z., Yang, B., Du, X.Q., Yi, C. Optimisation of supercritical fluid extraction of flavonoids. Purification Technology 108, 737-741. 2008.
 
[41]  Hanae I.Z.U., Megumi, S., Yasuko, M., Kuniyasu, G., Haruyuki, I. S-adenosylmethionine (SAM)-accumulating aake aeast auppresses acute alcohol-induced liver injury in mice. Bioscience, Biotechnology, and Biochemistry 70, 2982-2989. 2006.