Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2019, 7(4), 279-286
DOI: 10.12691/jfnr-7-4-4
Open AccessA Clinical Study

Association between Peripheral Leukocyte Telomere Length and Dietary Vitamin A and Carotenoid in U.S. Adults

Li Yi1, Gao Lijie1, Han Nannan2, Wang Chaoqun3, Luo Weijia4, Tian Ye1, 2, and Shi Wenzhen2,

1Medicine college, Yan’an University, Yan’an, PR China

2Neurology Department, Xi’an No.3 hospital, Xi’an, PR China

3Respiratory Department, Chengdu Second Hospital of Traditional Chinese Medicine, Chengdu, PR China

4Respiratory Department, MeiShan Hospital of Traditional Chinese Medicine, MeiShan, PR China

Pub. Date: April 03, 2019

Cite this paper:
Li Yi, Gao Lijie, Han Nannan, Wang Chaoqun, Luo Weijia, Tian Ye and Shi Wenzhen. Association between Peripheral Leukocyte Telomere Length and Dietary Vitamin A and Carotenoid in U.S. Adults. Journal of Food and Nutrition Research. 2019; 7(4):279-286. doi: 10.12691/jfnr-7-4-4

Abstract

To investigate the independent association between peripheral leukocyte telomere length and dietary vitamin A and carotenoid, we collected 839 participants older than 20-year from the 1999-2000 National Health and Nutrition Examination Survey. The peripheral leukocyte telomere length was obtained using the quantitative polymerase chain reaction method. Dietary information, such as alcohol, caffeine, carotenoid, folate and vitamin A/B1/B2/B6/B12/C/E was from a recall of the previous 24h taken food. Multivariable logistic regression and smooth curve fitting was conducted to analyze the independent association between telomere length and dietary vitamin A and carotenoid. Obesity was further treated as effect modification factor in the stratified analysis. After adjusting for age, race, sex, education, obesity, physical activity, PIR, smoking status, CAD history, serum concentrations of vitamin E/A/B12, folate, gamma-tocopherol, CRP, total cholesterol, cadmium and dietary intake of alcohol, caffeine, fiber, folate and vitamin B1/B2/B6/B12/C/E, the daily vitamin A and carotenoid intake was not significantly associated with telomere length in general population (vitamin A: 0.0009, 95% CI: -0.0041, 0.0058; carotenoid: 0.0040, 95% CI: -0.0458, 0.0538). In non-obesity population, the association coefficient was -0.0121 (95% CI: -0.0259, 0.0017) for vitamin A and -0.1369 (95% CI: -0.2809, 0.0070) for carotenoid. Vitamin A and carotenoid consumption was not associated with peripheral leukocyte telomere length independently in general adult population. However, in non-obese individuals, increasing vitamin A and carotenoid might tend to associate with decreasing peripheral leukocyte telomere length.

Keywords:
diet nutrition antioxidative nutrient aging obesity

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