Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2019, 7(1), 71-81
DOI: 10.12691/jfnr-7-1-9
Open AccessArticle

Association of Food Intolerance with Coronary Artery Disease

Angeliki Tsantsaridou1, Vissarion – Panagiotis Papathanasiou2 and Gerasimos Dimisianos3,

1Department of Cardiovascular and Thoracic Surgery, Larissa University Hospital, Larissa, Greece

2MSc Statistician, Levadia, Greece

3Molecular Biologist, PhD, Larissa, Greece

Pub. Date: January 25, 2019

Cite this paper:
Angeliki Tsantsaridou, Vissarion – Panagiotis Papathanasiou and Gerasimos Dimisianos. Association of Food Intolerance with Coronary Artery Disease. Journal of Food and Nutrition Research. 2019; 7(1):71-81. doi: 10.12691/jfnr-7-1-9

Abstract

Background: Hippocrates wisely said that «your food be your medicine and that nature is the doctor of diseases». In the Holy Scriptures the «clean from the unclean foods» are separated. In this pilot study, we tried to uncover any intolerances to foods of patients with coronary artery disease. Aim: The purpose of this trial was to evaluate any food categories that stimulate the immune system of patients with coronary heart disease by creating a vicious circle of inflammation, including atherogenesis. The analysis will contribute to possibly understand patients with coronary artery disease, the aetiopathogenesis of the underlying disease and implement the appropriate therapeutic nutrition. Materials and methods: The presence of IgG antibodies were detected using a kit (Golden test) with ELISA method in 63 patients and 12 healthy individuals. Results: The analysis revealed that more frequent intolerances were in banana, milk products and eggs. The tests showed statistical differences for banana and milk among the two groups. Conclusions: Although most patients had an intolerance in bananas, eggs and milk, this work does not verify the association of food intolerances with the etiology of coronary artery disease.

Keywords:
immune system IgG coronary artery disease food intolerance

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References:

[1]  Dimitrios Tsiantoulas, Cody J. Diehl, Joseph L. Witztum, and Christoph J. Binder. B Cells and Humoral Immunity in Atherosclerosis. Circ Res. 2014 May 23; 114(11): 1743-56.
 
[2]  Blum A1, Peleg A, Weinberg M. Anti-cytomegalovirus (CMV) IgG antibody titer in patients with risk factors to atherosclerosis. Clin Exp Med. 2003 Nov; 3(3):157-60.
 
[3]  Sun YH1, Pei WD, Wu YJ, Wang GG. Zhonghua Yi Xue Za Zhi. Association of herpes simplex virus type2 infection with dyslipidemia in Chinese. 2003 Oct 25;83(20):1774-7. Chinese.
 
[4]  Sundgren NC, Vongpatanasin W, Boggan BM, Tanigaki K, Yuhanna IS, Chambliss KL, Mineo C, Shaul PW. IgG receptor FcγRIIB plays a key role in obesity-induced hypertension. Hypertension. 2015 Feb; 65(2): 456-62.
 
[5]  Gao M, Li Y, Zheng A, Xue X, Chen L, Kong Y. Lymphocyte oxidative stress/genotoxic effects are related to serum IgG and IgA levels in coke oven workers. Scientific World Journal. 2014; 2014: 801346.
 
[6]  De Batista PR, Palacios R, Martín A, Hernanz R, Médici CT, Silva MA, Rossi EM, Aguado A, Vassallo DV, Salaices M, Alonso MJ. Toll-like receptor 4 upregulation by angiotensin II contributes to hypertension and vascular dysfunction through reactive oxygen species production. PLoS One. 2014 Aug 5;9(8): e104020.
 
[7]  Kounis NG, Soufras GD, Tsigkas G, Hahalis G. White blood cell counts, leukocyte ratios, and eosinophils as inflammatory markers in patients with coronary artery disease. Clin Appl Thromb Hemost. 2015 Mar; 21(2): 139-43.
 
[8]  Bakirci EM, Demirtas L, Degirmenci H, Topcu S, Demirelli S, Hamur H, Buyuklu M, Akbas EM, Ozcicek A, Ozcicek F, Ceyhun G, Topal E. Relationship of the total atrial conduction time to subclinical atherosclerosis, inflammation and echocardiographic parameters in patients with type 2 diabetes mellitus. Clinics (Sao Paulo). 2015 Feb; 70(2): 73-80.
 
[9]  Ceccarelli G1, d'Ettorre G, Mancone M, Francone M, Vullo V. Accelerated coronary atherosclerosis after execution of percutaneous coronary intervention in patient with HIV/HCV coinfection: case report and review of the literature. Cardiovasc Revasc Med. 2011 Jul-Aug; 12(4): 262-5.
 
[10]  Miller PS1, Evangelista LS, Giger JN, Martinez-Maza O, Corvera-Tindel T, Magpantay L, Pena G, Doering LV. Exhaustion, immuno-inflammation, and pathogen burden after cardiac surgery: an exploratory study. Eur J Cardiovasc Nurs. 2014 Jun; 13(3): 211-20.
 
[11]  Thomas P. Erlinger, MD, MPH; Edgar R. Miller III, MD, PhD; Jeanne Charleston, RN; Lawrence J. Appel, MD, MPH. Inflammation Modifies the Effects of a Reduced-Fat Low-Cholesterol Diet on Lipids Results From the DASH-Sodium Trial. Circulation. 2003 Jul 15; 108(2): 150-4.
 
[12]  Elaine Paffen, Moniek P.M. C-reactive protein in atherosclerosis: A causal factor? deMaat j.cardiores. 2006. 03.004 30-39.
 
[13]  Goldschmidt-Clermont PJ1, Dong C, Seo DM, Velazquez OC. Atherosclerosis, inflammation, genetics, and stem cells: 2012 update. Curr Atheroscler Rep. 2012 Jun; 14(3): 201-10.
 
[14]  Mercer JR1, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, Bennett M. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res. 2010 Oct 15; 107(8): 1021-31.
 
[15]  Bagnato C1, Thumar J, Mayya V, Hwang SI, Zebroski H, Claffey KP, Haudenschild C, Eng JK, Lundgren DH, Han DK. Proteomics analysis of human coronary atherosclerotic plaque: a feasibility study of direct tissue proteomics by liquid chromatography and tandem mass spectrometry. Mol Cell Proteomics. 2007 Jun; 6(6): 1088-102.
 
[16]  Sanner JE1, Frazier L. The role of serotonin in depression and clotting in the coronary artery disease population. J Cardiovasc Nurs. 2011 Sep-Oct; 26(5): 423-9.
 
[17]  Lüscher TF1. Thrombocyte-vascular wall interaction and coronary heart disease. Schweiz Med Wochenschr. 1991 Dec 28; 121(51-52): 1913-22. Review. German. PMID: 1763300.
 
[18]  Demirtürk M1, Polat N, Güz G, Gürdal A, Altun I, Gelincik A, Toz B, Oflaz H, Çolakoğlu B, Dal M, Büyüköztürk S. There is an increased risk of atherosclerosis in hereditary angioedema. Int Immunopharmacol. 2012 Jan; 12(1): 212-6.
 
[19]  Theoharides TC Clin Ther. Is a subtype of autism an allergy of the brain? 2013 May; 35(5): 584-91.
 
[20]  Eelen G, de Zeeuw P, Simons M, Carmeliet P. Endothelial cell metabolism in normal and diseased vasculature. Circ Res. 2015 Mar 27; 116(7): 1231-44.
 
[21]  Kim YW1, Byzova TV. Oxidative stress in angiogenesis and vascular disease. Blood. 2014 Jan 30; 123(5): 625-31.
 
[22]  Greenberg DA1, Jin K. Vascular endothelial growth factors (VEGFs) and stroke. Cell Mol Life Sci. 2013 May; 70(10): 1753-61.
 
[23]  Tetè S, Tripodi D, Rosati M, Conti F, Maccauro G, Saggini A, Salini V, Cianchetti E, Caraffa A, Antinolfi P, Toniato E, Castellani ML, Pandolfi F, Frydas S, Conti P, Theoharides TC. Endothelial cells, cholesterol, cytokines, and aging. Int J Immunopathol Pharmacol. 2012 Apr-Jun; 25(2):355-63.
 
[24]  Owczarek A1, Babińska M, Szyguła-Jurkiewicz B, Chudek J. Chronic inflammation in patients with acute coronary syndrome and chronic kidney disease. Kardiol Pol. 2011; 69(4): 388-93.
 
[25]  Virdis A1, Schiffrin EL. Vascular inflammation: a role in vascular disease in hypertension? Curr Opin Nephrol Hypertens. 2003 Mar; 12(2): 181-7.
 
[26]  Anna Rybak, Bożena Cukrowska, Jerzy Socha, and Piotr Socha. Long Term Follow Up of Celiac Disease—Is Atherosclerosis a Problem? Nutrients. 2014 Jul 21; 6(7): 2718-29.
 
[27]  Saeed F1, Pasha I, Anjum FM, Sultan MT. Arabinoxylans and arabinogalactans: a comprehensive treatise. Crit Rev Food Sci Nutr. 2011 May; 51(5): 467-76.
 
[28]  Thiel C1. Food allergies and intolerance reactions. Z Ernahrungswiss. 1991 Sep; 30(3): 158-73.
 
[29]  Sarzi-Puttini P1, Atzeni F, Carrabba M. Cardiovascular risk factors in systemic lupus erythematosus and in antiphospholipid syndrome. Minerva Med. 2003 Apr; 94(2): 63-70.
 
[30]  Storch H, Reuter W Z. Immune reactivity in patients with disorders of lipid metabolism. Gesamte Inn Med. 1981 Apr 1; 36(7): 289-92.
 
[31]  Beaumont JL, Berard M, Antonucci M, Delplanque B, Vranckx R. Inhibition of lipoprotein lipase activity by a monoclonal immunoglobulin in autoimmune hyperlipidemia. Atherosclerosis. 1977 Jan; 26(1): 67-77.
 
[32]  James TG Li M.D.. What is the difference between a food intolerance and food allergy? June 3, 2011, Mayo Clinic, Mayo Foundation for Medical Education and Research. Accessed November 9th 2013.
 
[33]  Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014 Jun; 46(3): 225-40.
 
[34]  Genuis SJ. Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity. Sci Total Environ. 2010 Nov 15; 408(24): 6047-61.
 
[35]  Review article: the aetiology, diagnosis, mechanisms and clinical evidence for food intolerance. Aliment Pharmacol Ther 2014 Dec 3.
 
[36]  Ohtsuka Y. Food intolerance and mucosal inflammation. Paediatr Int. 2015 Feb; 57(1): 22-29.
 
[37]  Croca S, Bassett P, Chambers S, Davari M, Alber KF, Leach O, Ioannou Y, Giles I, Isenberg D, Rahman A. IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. Arthritis Res Ther. 2015 Feb 9; 17(1): 26.
 
[38]  Montecucco F, Braunersreuther V, Burger F, Lenglet S, Pelli G, Carbone F, Fraga-Silva R, Stergiopulos N, Monaco C, Mueller C, Pagano S, Dallegri F, Mach F, Vuilleumier N. Anti-apoA-1 auto-antibodies increase mouse atherosclerotic plaque vulnerability, myocardial necrosis and mortality triggering TLR2 and TLR4. Thromb Haemost. 2015 Apr 16; 114(20150416). [Epub ahead of print] PMID:25879306.
 
[39]  Caselli M, Zuliani G, Cassol F, Fusetti N, Zeni E, Lo Cascio N, Soavi C, Gullini S. Test-based exclusion diets in gastro-esophageal reflux disease patients: a randomized controlled pilot trial. World J Gastroenterol. 2014 Dec 7; 20(45): 17190-5.
 
[40]  Signs of microbial sensibilization in patients with various cardiovascular diseases. Zh Mikrobiol Epidemiol Immunobiol. 2015 Jan-Feb; (1): 75-81.
 
[41]  Pietschmann N. Food Intolerance: Immune Activation Through Diet-associated Stimuli in Chronic Disease. Altern Ther Health Med. 2015 Jul; 21(4): 42-52.
 
[42]  Merched AJ1, Chan L. Nutrigenetics and nutrigenomics of atherosclerosis. Curr Atheroscler Rep. 2013 Jun; 15(6): 328.
 
[43]  Skibska B, Goraca A. The Protective Effect of Lipoic Acid on Selected Cardiovascular Diseases Caused by Age-Related Oxidative Stress. Oxid Med Cell Longev. 2015;2015:313021. Epub 2015 Apr 8. Review. PMID: 25949771
 
[44]  Pietschmann N. Food Intolerance: Immune Activation Through Diet-associated Stimuli in Chronic Disease. Altern Ther Health Med. 2015 Jul; 21(4): 42-52.
 
[45]  Fritscher-Ravens A, Schuppan D, Ellrichmann M, Schoch S, Röcken C, Brasch J, Bethge J, Böttner M, Klose J, Milla PJ. Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Gastroenterology. 2014 Nov; 147(5): 1012-20. e4.
 
[46]  Cuomo R, Andreozzi P, Zito FP, Passananti V, De Carlo G, Sarnelli G. Irritable bowel syndrome and food interaction. World J Gastroenterol. 2014 Jul 21; 20(27): 8837-45.
 
[47]  Skibska B, Goraca A. The Protective Effect of Lipoic Acid on Selected Cardiovascular Diseases Caused by Age-Related Oxidative Stress. Oxid Med Cell Longev. 2015; 2015: 313021. Epub 2015 Apr 8.
 
[48]  Merched AJ. Nutrigenetics and nutrigenomics of atherosclerosis. Chan L. Curr Atheroscler Rep. 2013 Jun; 15(6): 328.
 
[49]  Kotlyar DS, Shum M, Hsieh J, Blonski W, Greenwald DA. Non-pulmonary allergic diseases and inflammatory bowel disease: a qualitative review. World J Gastroenterol. 2014 Aug 28; 20(32): 11023-32.
 
[50]  Vojdani A. Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. Nutr Metab (Lond). 2009 May 12; 6: 22.
 
[51]  Palermo A1, Maggi D, Maurizi AR, Pozzilli P, Buzzetti R. Prevention of type 2 diabetes mellitus: is it feasible? Diabetes Metab Res Rev. 2014 Mar; 30 Suppl 1: 4-12.
 
[52]  Mansueto P, D'Alcamo A, Seidita A, Carroccio A. Food allergy in irritable bowel syndrome: The case of non-celiac wheat sensitivity. World J Gastroenterol. 2015 Jun 21; 21(23): 7089-109.
 
[53]  Green PH, Lebwohl B, Greywoode R. Celiac disease. J Allergy Clin Immunol. 2015 May; 135(5): 1099-1106.
 
[54]  Parfenov AI, Akhmadullina OV, Sabel'nikova EA, Belostotskii NI, Gudkova RB, Khomeriki SG. Carbohydrase activities may serve as a marker for small intestinal mucosal recovery in patients with celiac disease. Ter Arkh. 2015; 87(2): 24-9.
 
[55]  Ohtsuka Y. Food intolerance and mucosal inflammation. Paediatr Int. 2015 Feb; 57(1): 22-29.
 
[56]  Lomer MC. Review article: the aetiology, diagnosis, mechanisms and clinical evidence for food intolerance. Aliment Pharmacol Ther. 2015 Feb; 41(3): 262-75.
 
[57]  Frehn L, Jansen A, Bennek E, Mandic AD, Temizel I, Tischendorf S, Verdier J, Tacke F, Streetz K, Trautwein C, Sellge G. Distinct patterns of IgG and IgA against food and microbial antigens in serum and feces of patients with inflammatory bowel diseases. PLoS One. 2014 Sep 12; 9(9): e106750.
 
[58]  Wilson K. The role of food intolerance in functional gastrointestinal disorders in children. Hill RJ Aust Fam Physician. 2014 Oct; 43(10): 686-9.
 
[59]  Di Cerbo A, Canello S, Guidetti G, Laurino C, Palmieri B5. Unusual antibiotic presence in gym trained subjects with food intolerance; a case report. Nutr Hosp. 2014 Aug 1; 30(2): 395-8.
 
[60]  Vorozhko IV, Sentsova TB, Kirillova OO, Gapparova, Chekhonina IuG. Soluble apoptosis markers in obese patients with food intolerance. Vopr Pitan. 2014; 83(2): 22-6.
 
[61]  Lomer MC. Review article: the aetiology, diagnosis, mechanisms and clinical evidence for food intolerance. Aliment Pharmacol Ther. 2015 Feb; 41(3): 262-75.
 
[62]  Lik Sprava. The link between food intolerance and weight: a new perspective in the treatment of obesity. Rotter MM. 2014 Jan-Feb; (1-2): 87-91. Ukrainian. PMID: 24908967.
 
[63]  Storch H, Reuter W Z. Immune reactivity in patients with disorders of lipid metabolism. Gesamte Inn Med. 1981 Apr 1; 36(7): 289-92.
 
[64]  Beaumont JL, Berard M, Antonucci M, Delplanque B, Vranckx R. Inhibition of lipoprotein lipase activity by a monoclonal immunoglobulin in autoimmune hyperlipidemia. Atherosclerosis. 1977 Jan; 26(1): 67-77.
 
[65]  Okamoto Y1, Tominaga K, Uemura S, Matsuoka H, Tsujii T, Nakano H. Hypertriglyceridemia caused by the autoantibody to lipases for plasma lipoproteins: a case report. J Atheroscler Thromb. 1995; 2(1): 66-9.
 
[66]  Sarzi-Puttini P, Atzeni F. Cardiovascular risk factors in systemic lupus erythematosus and in antiphospholipid syndrome. Carrabba M. Minerva Med. 2003 Apr; 94(2): 63-70.
 
[67]  Paula A. Hayes, BSc, Marianne H. Fraher, MB, MRCPI, FRCPath, and Eamonn M. M. Quigley, MD, FRCP, FACP, FACG, Irritable Bowel Syndrome: The Role of Food in Pathogenesis and Management. FRCPI corresponding author Gastroenterol Hepatol (N Y). 2014 Mar; 10(3): 164-74.
 
[68]  Sentsova TB, Vorozhko IV, Isakov VA, Morozov SV, Shakhovskaia AK. Immune status estimation algorithm in irritable bowel syndrome patients with food intolerance. Eksp Klin Gastroenterol. 2014; (7):13-7. Russian.
 
[69]  [Article in Chinese] Liu XJ, Zhu TT, Zeng R, Chang L, Li FY, Li WS, Jiang YM. An epidemiological study of food intolerance in 2434 children. Zhongguo Dang Dai Er Ke Za Zhi. 2013 Jul; 15(7): 550-4. Chinese.
 
[70]  Anna Rybak, Bożena Cukrowska, Jerzy Socha, and Piotr Socha. Long Term Follow Up of Celiac Disease—Is Atherosclerosis a Problem? Nutrients. 2014 Jul 21; 6(7): 2718-29.
 
[71]  Christopher T. Chan, Maggie Lieu, Ban-Hock Toh, Tin S. Kyaw, Alexander Bobik, Christopher G. Sobey, and Grant R. Drummond. Antibodies in the Pathogenesis of Hypertension. Biomed Res Int. 2014; 2014: 504045.