Journal of Cancer Research and Treatment
ISSN (Print): 2374-1996 ISSN (Online): 2374-2003 Website: Editor-in-chief: Jean Rommelaere
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Journal of Cancer Research and Treatment. 2018, 6(1), 25-27
DOI: 10.12691/jcrt-6-1-5
Open AccessMini Review

Indole-3-carbinol: A Promising Hope for Cancer Therapy

Ahmed M. Kabel1, 2, , Eman A. Alharthi3, Rana K. Alshehri3 and Afnan S. Alghamdi3

1Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, KSA

2Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt

3Pharm D, College of Pharmacy, Taif University, Taif, KSA

Pub. Date: April 17, 2018

Cite this paper:
Ahmed M. Kabel, Eman A. Alharthi, Rana K. Alshehri and Afnan S. Alghamdi. Indole-3-carbinol: A Promising Hope for Cancer Therapy. Journal of Cancer Research and Treatment. 2018; 6(1):25-27. doi: 10.12691/jcrt-6-1-5


Indole-3-carbinol (I3C) is a natural agent found in high amounts in cruciferous vegetables and is also available as dietary supplements. It is considered as a promising agent for the ongoing medical research due to its possible antioxidant, anti-inflammatory, anti-tumor, antiapoptotic and anti-atherogenic properties. Recent studies are directed towards assessment of the possible effects of I3C on various body organs including the heart, liver, kidney and the endocrine system. This mini-review sheds light on the different properties of I3C that make it a promising therapeutic agent for a wide variety of human diseases including cancer.

cruciferous vegetables indole-3-carbinol natural agent cancer

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[1]  Kabel AM, Abd Elmaaboud MA. Cancer: Role of Nutrition, Pathogenesis, Diagnosis and Management. World Journal of Nutrition and Health 2014; 2(4): 48-51.
[2]  Al-Harthi SE, Alarabi OM, Ramadan WS, Alaama MN, Al-Kreathy HM, Damanhouri ZA, Khan LM, Osman AM. Amelioration of doxorubicin induced cardiotoxicity by resveratrol. Mol Med Rep 2014; 10: 1455-60.
[3]  Sultana S, Asif HM, Nazar HM, Akhtar N, Rehman JU, Rehman RU. Medicinal plants combating against cancer--a green anticancer approach. Asian Pac J Cancer Prev 2014; 15(11): 4385-94.
[4]  Mondal S, Bandyopadhyay S, Ghosh MK, Mukhopadhyay S, Roy S, Mandal C. Natural products: promising resources for cancer drug discovery. Anticancer Agents Med Chem 2012; 12(1): 49-75.
[5]  Kabel AM, Al-Shehri AH, Al-Talhi RA, Abd Elmaaboud MA (2017). The promising effect of linagliptin and/or indole-3-carbinol on experimentally-induced polycystic ovarian syndrome. Chemico-Biological Interactions 273: 190-199.
[6]  Bosetti C, Filomeno M, Riso P, Polesel J, Levi F, Talamini R, Montella M, Negri E, Franceschi S, La Vecchia C. Cruciferous vegetables and cancer risk in a network of case-control studies. Ann Oncol 2012; 23 (8): 2198-203.
[7]  Hu J, Hu Y, Hu Y, Zheng S. Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis. Asia Pac J Clin Nutr 2015; 24(1): 101-9.
[8]  Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection. Curr Drug Metab 2016; 17(4): 401-9.
[9]  Higdon JV, Delage B, Williams DE, Dashwood RH. Cruciferous Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic Basis. Pharmacol res 2007; 55(3): 224-236.
[10]  Anderton MJ, Manson MM, Verschoyle RD, Gescher A, Lamb JH, Farmer PB, Steward WP, Williams ML. Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice. Clin Cancer Res 2004; 10(15): 5233-41.
[11]  Burns KA, Korach KS. Estrogen receptors and human disease: an update. Arch Toxicol 2012; 86(10): 1491-504.
[12]  Auborn KJ1, Qi M, Yan XJ, Teichberg S, Chen D, Madaio MP, Chiorazzi N. Lifespan is prolonged in autoimmune-prone (NZB/NZW) F1 mice fed a diet supplemented with indole-3-carbinol. J Nutr 2003; 133(11): 3610-13.
[13]  Yan XJ, Qi M, Telusma G, Yancopoulos S, Madaio M, Satoh M, Reeves WH, Teichberg S, Kohn N, Auborn K, Chiorazzi N. Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades. Clin Immunol 2009; 131(3): 481-94.
[14]  Chang HP, Wang ML, Hsu CY, Liu ME , Chan MH, Chen YH. Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes. Int J Obes 2011; 35: 1530-38.
[15]  Deng W, Wei L, Zong J, Bian Z, Zhou H, Zhang R, Tang Q. Attenuation of cardiac remodeling by indole-3-carbinol in mice is associated with improved energy metabolism. Int J Cardiol 2014; 172: e531-e33.
[16]  Rogan EG. The Natural Chemopreventive Compound Indole-3-carbinol: State of the Science. In Vivo 2006; 20: 221-8.
[17]  Hsu JC, Dev A, Wing A, Brew CT, Bjeldanes LF, Firestone GL. Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein. Biochem Pharmacol 2006; 72(12): 1714-23.
[18]  Segawa R, Hayashi H, Morita R, Ogawa T, Takimoto N, Hara S, et al. Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital. J Toxicol Sci 2014; 39(1): 129-40.
[19]  Shimamoto K, Dewa Y, Ishii Y, Kemmochi S, Taniai E, Hayashi H, et al. Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine. Toxicology 2011; 283(2-3): 109-17.