Journal of Cancer Research and Treatment
ISSN (Print): 2374-1996 ISSN (Online): 2374-2003 Website: http://www.sciepub.com/journal/jcrt Editor-in-chief: Jean Rommelaere
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Journal of Cancer Research and Treatment. 2013, 1(2), 31-35
DOI: 10.12691/jcrt-1-2-2
Open AccessReview Article

Long Non-Coding RNAs: Novel Emergent Biomarkers for Cancer Diagnostics

Duncan Ayers1,

1Department of Pathology, Faculty of Medicine & Surgery, University of Malta, Msida MDS, MALTA.

Pub. Date: September 12, 2013

Cite this paper:
Duncan Ayers. Long Non-Coding RNAs: Novel Emergent Biomarkers for Cancer Diagnostics. Journal of Cancer Research and Treatment. 2013; 1(2):31-35. doi: 10.12691/jcrt-1-2-2

Abstract

Long non-coding RNAs are a novel class of approximately 15,000 – 20,000 non-protein coding RNAs, having a base length of over 200 nucleotides and are the result of RNA Polymerase II activities. Long non-coding RNAs have only just recently been identified to play a major role in gene regulatory pathways for a wide spectrum of human disease conditions, including multiple cancer models. This review article serves to outline, through recent scientific evidence, the emerging importance of long non-coding RNAs as key biomarkers in cancer diagnostics and therapeutics within the clinical setting. Ultimately, there will be soon the establishment of long non-coding RNA expression profile signature analyses on a par level with other molecular diagnostic techniques such as mRNA and miRNA expression profiles for the identification and monitoring of tumour progression and sensitivity to treatment within the individual cancer patient.

Keywords:
lncRNA miRNA cancer biomarker diagnosis

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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