Journal of Cancer Research and Treatment
ISSN (Print): 2374-1996 ISSN (Online): 2374-2003 Website: http://www.sciepub.com/journal/jcrt Editor-in-chief: Jean Rommelaere
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Journal of Cancer Research and Treatment. 2016, 4(3), 52-54
DOI: 10.12691/jcrt-4-3-4
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Wilms’ Tumor of the Kidney: Insights into Risk Factors, Pathogenesis, Diagnosis and Management

Ahmed M. Kabel1, 2, , Manal Alosaimy3, Walaa Aljeaid3, Bayan Alhumaiany3 and Nada Albardi3

1Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, KSA

2Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt

3Final year student, College of Pharmacy, Taif University, Taif, KSA

Pub. Date: July 08, 2016

Cite this paper:
Ahmed M. Kabel, Manal Alosaimy, Walaa Aljeaid, Bayan Alhumaiany and Nada Albardi. Wilms’ Tumor of the Kidney: Insights into Risk Factors, Pathogenesis, Diagnosis and Management. Journal of Cancer Research and Treatment. 2016; 4(3):52-54. doi: 10.12691/jcrt-4-3-4

Abstract

Wilms’ tumor is a rare disease of the kidney that usually affects newborn and young children. It is the commonest renal tumor of childhood affecting one in 10,000 children. It may spread into the other kidney if it has not been discovered early. Diagnosis depends on physical examination and radiographic images while the treatment decision is taken after determining the stage of the disease according to the occurrence of metastasis or the presence of the cancer cells in both kidneys. Lines of treatment include surgical excision, high dose chemotherapy and radiotherapy. Prognosis depends on the stage of the disease at diagnosis, tumor size, histopathological features of the tumor and the age of the patient.

Keywords:
Kidney Wilms’ cancer stages management

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Cone EB, Dalton SS, Van Noord M, Tracy ET, Rice HE, Routh JC. Biomarkers for Wilms Tumor: a Systematic Review. J Urol 2016; S0022-5347(16)30549-3.
 
[2]  Dome JS, Cotton CA, Perlman EJ, et al. Treatment of anaplastic histology Wilms’ tumor: Results from the fifth National Wilms’ Tumor Study. J Clin Oncol 2006; 24:2352-8.
 
[3]  Davidoff AM. Wilms’ tumor. Adv Pediatr 2012; 59: 247-67.
 
[4]  Geller JI, Dome JS. Molecular Targeted Therapy for Wilms’ Tumor. In: Houghton PJ, Arceci RJ, eds. Molecularly Targeted Therapy for Childhood Cancer. New York, NY: Springer; 2010: 401-24.
 
[5]  Green DM. The evolution of treatment for Wilms’ tumor. J Pediatr Surg 2013; 48:14-9.
 
[6]  Ko EY, Ritchey ML. Current management of Wilms’ tumor in children. J Pediatr Urol 2009; 5:56-65.
 
[7]  Zakaria OM, Daoud MY, Farrag SH, Mulhim AS. Efficacy of Different Protocols in Treatment of Nephroblastoma: A revisit. Gulf J Oncolog 2016; 1(21): 55-60.
 
[8]  Reid S, Renwick A, Seal S, et al. Biallelic BRCA2 mutations are associated with multiple malignancies in childhood including familial Wilms’ tumour. J Med Genet 2005; 42 (2): 147-51.
 
[9]  Yasri S, Wiwanitkit V. Wilms' tumour and chemotherapeutic access. African Journal of Paediatric Surgery 2015; 12(3):208.
 
[10]  Dome JS, Perlman EJ, Graf N. Risk stratification for Wilms' tumor: current approach and future directions. Am Soc Clin Oncol Educ Book 2014:215-23.
 
[11]  Dome JS, Graf N, Geller JI, Fernandez CV, Mullen EA, Spreafico F, et al. Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration. J Clin Oncol 2015; 33(27):2999-3007.
 
[12]  Szychot E, Brodkiewicz A, Pritchard-Jones K. Review of current approaches to the management of Wilms’ tumor. Int J Clin Rev 2012; 18 (3):65.
 
[13]  Fuchs J, Szavay P, Luithle T, et al. Surgical implications forliver metastases in ephroblastoma--data from the SIOP/GPOH study. Surg Oncol 2008; 17:33-40.
 
[14]  Dome JS, Fernandez CV, Mullen EA, et al. Children’s Oncology Group’s 2013 blueprint for research: Renal tumors. Pediatr Blood Cancer 2013; 60:994-1000.
 
[15]  Szychot E, Apps J, Pritchard-Jones K. Wilms’ tumor: biology, diagnosis and treatment. Transl Pediatr 2014; 3(1): 12-24.
 
[16]  Kaste SC, Dome JS, Babyn PS, Graf NM, Grundy P, Godzinski J, et al. Wilms’ tumour: prognostic factors, staging, therapy and late effects. Pediatr Radiol 2008; 38(1):2-17.
 
[17]  Kabel AM, Abd Elmaaboud MA. Cancer: Role of Nutrition, Pathogenesis, Diagnosis and Management. World Journal of Nutrition and Health 2014; 2(4): 48-51.
 
[18]  Nakayama DK, Bonasso PC. The History of Multimodal Treatment of Wilms' Tumor. Am Surg 2016; 82(6):487-92.
 
[19]  Sarin YK, Bhatnagar SN. Wilms’ tumor- roadmaps of management. Indian J Pediatr 2012; 79(6):776-86.
 
[20]  Sarin YK, Graf N. Management of Recurrent Wilms’ tumor. JIMSA 2014; 27(2): 91-4.
 
[21]  Smith MA, Altekruse SF, Adamson PC, et al. Declining childhood and adolescent cancer mortality. Cancer 2014; 120 (16): 2497-506.
 
[22]  Routh JC, Grundy PE, Anderson JR, et al. B7-h1 as a biomarker for therapy failure in patients with favorable histology Wilms’ tumor. J Urol 2013; 189 (4): 1487-92.
 
[23]  Segers H, van den Heuvel-Eibrink MM, Pritchard-Jones K, et al. SIOP-RTSG and the COG-Renal Tumor Committee. Management of adults with Wilms’ tumor: recommendations based on international consensus. Expert Rev Anticancer Ther 2011; 11:1105-13.
 
[24]  Hu J, Jin LU, He T, Li Y, Zhao Y, Ding YU, et al. Wilms' tumor in a 51-year-old patient: An extremely rare case and review of the literature. Mol Clin Oncol 2016 Jun;4(6):1013-16.
 
[25]  Gill IS, Kavoussi LR, Lane BR, et al. Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. J Urol 2007; 178:41-6.