Journal of Cancer Research and Treatment
ISSN (Print): 2374-1996 ISSN (Online): 2374-2003 Website: Editor-in-chief: Jean Rommelaere
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Journal of Cancer Research and Treatment. 2019, 7(1), 17-20
DOI: 10.12691/jcrt-7-1-3
Open AccessMini Review

Doxorubicin: Insights into Dynamics, Clinical Uses and Adverse Effects

Amal A. Alghorabi1, Ahmed M. Kabel2, 3, and Maaly A. Abd Elmaaboud2

1Pharm D, College of Pharmacy, Taif University, Taif, Saudi Arabia

2Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

3Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia

Pub. Date: July 24, 2019

Cite this paper:
Amal A. Alghorabi, Ahmed M. Kabel and Maaly A. Abd Elmaaboud. Doxorubicin: Insights into Dynamics, Clinical Uses and Adverse Effects. Journal of Cancer Research and Treatment. 2019; 7(1):17-20. doi: 10.12691/jcrt-7-1-3


Doxorubicin (DOX) is one of the anthracycline antibiotics that is used frequently for treatment of various types of malignancies including lung, breast and testicular cancers. DOX reacts with DNA by intercalation and inhibits the synthesis of DNA macromolecular components. Also, it may increase the production of free radicals which may contribute to its cytotoxicity. DOX may cause serious adverse effects including cardiotoxicity, hepatotoxicity and testicular toxicity. So, it has become increasingly important to find pharmacological remedies to protect against these serious adverse effects. This mini-review sheds light on DOX including its history, dynamics, clinical uses and adverse effects.

doxorubicin dynamics uses toxicity

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