Journal of Biomedical Engineering and Technology
ISSN (Print): 2373-129X ISSN (Online): 2373-1303 Website: http://www.sciepub.com/journal/jbet Editor-in-chief: Ahmed Al-Jumaily
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Journal of Biomedical Engineering and Technology. 2020, 8(1), 1-5
DOI: 10.12691/jbet-8-1-1
Open AccessArticle

3D Modeling and Simulation of Airflow and Aerosol Deposition of 5 Years Child

Mohammed Almijalli1, Ravish Javed1, , Abdulrahman Aldokhi1, Fares Mohammed Alsuliman1, Kareem Adnan Alharbi1 and Omar Altwijri1

1Biomedical Technology Department, College of Applied Medical Sciences, King Saud University, KSA

Pub. Date: March 29, 2020

Cite this paper:
Mohammed Almijalli, Ravish Javed, Abdulrahman Aldokhi, Fares Mohammed Alsuliman, Kareem Adnan Alharbi and Omar Altwijri. 3D Modeling and Simulation of Airflow and Aerosol Deposition of 5 Years Child. Journal of Biomedical Engineering and Technology. 2020; 8(1):1-5. doi: 10.12691/jbet-8-1-1

Abstract

Children have special requirements in pulmonary drug delivery, as their lungs evolve continuously until they become adult. To deliver the drug to a specific area in the appropriate quantity, we need to study the deposition of particles. In our study we modelled and simulated airflow on a 5-year-old child using a CAD software to understand aerosol deposition. To design and simply the model of a child URT (Upper Respiratory Tract) on a CAD (Computer Aided Design) Software. Child specific model consist of mouth, trachea, and bronchi (left & right) with 11, 9, and 6.2 years old, respectively, was adopted. Using SolidWorks the URT model was sketched and extruded. All the simulation works were performed using software ANSYS CFX. An aerosol deposition converges at a steady-state condition for 500 iterations. A decrease in discharge was recorded as deposition transits from contraction prior to trachea at a velocity of 15 mm/s and a count of approximation of 28,000 with a time-lapse of 5 seconds. Therefore, the pressure and velocity of the particulate increases due to the contraction. Formulation particulate maximum velocity was recorded at 0.26 mm/s. Our findings suggest that a five-year-old URT model of a child has more aerosol depositions in comparison to adults and aerosol size range will evolve with age. In addition, deposition increase directly proportional to flow rate and with particle diameter.

Keywords:
aerosol deposition 5-year-old child upper respiratory tract computational modelling

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References:

[1]  Altwijri, O., et al., 3D Modeling and Simulation of Airflow and Aerosol Deposition of Idealized Human Oral Airways. Journal of Biomaterials and Tissue Engineering, 2018. 8(7): p. 933-940.
 
[2]  Verma, R.K. and S. Garg, Drug delivery technologies and future directions. Pharmaceutical Technology, 2001. 25(2): p. 1-14.
 
[3]  Töller, A.E., Voluntary Regulation by the Pharmaceutical Industry—Which Role for the Shadow of Hierarchy and Social Pressure? European Policy Analysis, 2017. 3(1): p. 48-80.
 
[4]  Langer, R., Drug delivery and targeting. NATURE-LONDON-, 1998: p. 5-10.
 
[5]  Nalwa, H.S., A special issue on reviews in nanomedicine, drug delivery and vaccine development. Journal of biomedical nanotechnology, 2014. 10(9): p. 1635-1640.
 
[6]  Fanun, M., Colloids in drug delivery. 2016: CRC Press.
 
[7]  Ciucă, A.G., et al., Nanostructures for drug delivery: pharmacokinetic and toxicological aspects, in Nanostructures for Drug Delivery. 2017, Elsevier. p. 941-957.
 
[8]  Kumeria, T., et al., Porous silicon for drug delivery applications and theranostics: recent advances, critical review and perspectives. Expert opinion on drug delivery, 2017. 14(12): p. 1407-1422.
 
[9]  Choi, Y.H. and H.-K. Han, Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics. Journal of pharmaceutical investigation, 2018. 48(1): p. 43-60.
 
[10]  Jena, M., et al., Nanotechnology-future prospect in recent medicine: a review. Int. J. Basic Clin. Pharmacol, 2013. 2(4): p. 353-359.
 
[11]  Darquenne, C., Aerosol deposition in health and disease. Journal of aerosol medicine and pulmonary drug delivery, 2012. 25(3): p. 140-147.
 
[12]  Bates, A.J., et al., Dynamics of airflow in a short inhalation. Journal of the Royal Society Interface, 2015. 12(102): p. 20140880.
 
[13]  Ma, B. and K.R. Lutchen, CFD simulation of aerosol deposition in an anatomically based human large–medium airway model. Annals of biomedical engineering, 2009. 37(2): p. 271.
 
[14]  Rubin, B.K. and R.W. Williams, Delivering therapy to the cystic fibrosis lung. Hodson and Geddes’ Cystic Fibrosis, 2015: p. 271.
 
[15]  Hickey, A.J., Practical Aspects of Imaging Techniques Employed to Study Aerosol Deposition and Clearance, in Pharmaceutical Inhalation Aerosol Technology, Second Edition. 2016, CRC Press. p. 180-221.
 
[16]  Lizal, F., et al., Experimental methods for flow and aerosol measurements in human airways and their replicas. European Journal of Pharmaceutical Sciences, 2018. 113: p. 95-131.
 
[17]  Youn, J.-s., et al., Hygroscopic properties and respiratory system deposition behavior of particulate matter emitted by mining and smelting operations. Environmental science & technology, 2016. 50(21): p. 11706-11713.
 
[18]  Moore, R.H. and R.A. Wood, The use of inhaler devices in children. 2017, UpToDate.
 
[19]  Fonceca, A.M., et al., Drug Administration by Inhalation in Children, in Kendig's Disorders of the Respiratory Tract in Children. 2019, Elsevier. p. 257-271. e3.
 
[20]  Rizvi, D.A., et al., Comparison of the efficacy of budesonide by nebulizer, metered dose inhaler and dry powder inhaler in chronic stable bronchial asthma. International Journal of Basic & Clinical Pharmacology, 2018. 7(7): p. 1333.
 
[21]  Hardin, A.P., et al., Age limit of pediatrics. Pediatrics, 2017. 140(3): p. e20172151.
 
[22]  Knoppert, D., et al., Paediatric age categories to be used in differentiating between listing on a model essential medicines list for children. Word Health Organization position paper, 2007. 1(5).
 
[23]  Organization, W.H., Paediatric age categories to be used in differentiating between listing on a model essential medicines list for children. 2014.
 
[24]  Martonen, T.B., et al., Flow simulation in the human upper respiratory tract. Cell biochemistry and biophysics, 2002. 37(1): p. 27-36.
 
[25]  Ahmad, N. and F. Proctor. Estimation of eddy dissipation rates from mesoscale model simulations. in 50th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition. 2012.