International Journal of Dental Sciences and Research
ISSN (Print): 2333-1135 ISSN (Online): 2333-1259 Website: http://www.sciepub.com/journal/ijdsr Editor-in-chief: Marcos Roberto Tovani Palone
Open Access
Journal Browser
Go
International Journal of Dental Sciences and Research. 2017, 5(2), 39-45
DOI: 10.12691/ijdsr-5-2-6
Open AccessArticle

Comparison of the Effects of Miconazole and Propolis in the Treatment of Candida-Associated Denture Stomatitis

Mohamed Y. Abdelfattah1, 2, , Tamer A. Aboshady3, Mohamed K.Fahmi4 and Marwa A.Amer1

1Prosthodontics, Faculty of Dentistry, Tanta University, Egypt

2Prosthodontics, Faculty of Dentistry, Taif University, KSA

3Periodontology, Oral Medicine, Diagnosis and Radiolology, Faculty of Dentistry, Tanta University, Egypt

4Restorative Dental Sciences, Faculty of Dentistry, Taif University, Taif, KSA

Pub. Date: March 15, 2017

Cite this paper:
Mohamed Y. Abdelfattah, Tamer A. Aboshady, Mohamed K.Fahmi and Marwa A.Amer. Comparison of the Effects of Miconazole and Propolis in the Treatment of Candida-Associated Denture Stomatitis. International Journal of Dental Sciences and Research. 2017; 5(2):39-45. doi: 10.12691/ijdsr-5-2-6

Abstract

PURPOSE: This study compared between the efficiency of propolis and miconazole gel as treatment modalities for Candida-associated denture stomatitis. MATERIALS AND METHODS: 20 patients suffering from Candida-associated denture stomatitis were divided into two treatment groups: Group I (control group): 10 patients received 20mg/g miconazole oral gel and Group II (study group): 10 patients received Bio-Propolis Capsules 2% (20mg/g). The patients were asked to use the miconazole oral gel or the propolis powder twice a day for 14 days. Examination was done on 1st, 7th and 14th days. Newtons’s criteria were used to classify the Pre-treatment and post-treatment (CHRO Magar Candida®) and counted through the colony forming unity count (CFU/mL). The intragroup comparison before and after each treatment was done using the Wilcoxon’s test while the Kruskall-Wallis’s test was used to compare the results of the two treatment groups. RESULTS: there was a considerable decrease or total cure of denture stomatitis (P<0.05) and a remarkable reduction of the number of Candida colonies in the two groups. Intergroup comparison revealed that no difference existed between both groups. Newton’s score were reduced in the two groups signifying the efficiency of both treatments. CONCLUSION: propolis powder has an antifungal activity similar to miconazole, in the treatment of Candida-associated denture stomatitis. Propolis is a safe, inexpensive, natural substance without any known side effects until now. It may therefore be safely to treat Candida-associated denture stomatitis.

Keywords:
candida-associated denture stomatitis miconazole gel propolis

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Giannini P. J. and Shetty K. V. Diagnosis and management of oral candidiasis Otolaryngologic. Clinics of North America. 2011; 44: 231-40.
 
[2]  Akpan A. and R. Morgan. Oral Candidiasis. Postgraduate Medical Journal 2002; 78: 455-59.
 
[3]  J. A. M. S. Jayatilake. A Review of the Ultra-structural Features of Superficial Candidiasis. Mycopathologia. 2011; 171: 235-50.
 
[4]  Samaranayake L. Commensal Oral Candida in Asian cohorts. International Journal of Oral Science2009; 1: 2-5.
 
[5]  Freitas J. B, R. S. Gomez, M. H. N. G. De Abreu, and E. Ferreira E Ferreira. Relationship between the use of full dentures and mucosal alterations among elderly Brazilians. Journal of Oral Rehabilitation2008; 35: 370-74.
 
[6]  Ramage G., K. Tomsett, B. L. Wickes, J. L. López-Ribot, and S. W. Redding. Denture stomatitis: a role for candida biofilms. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology2004; 98: 53-9.
 
[7]  Kulak Y, A. Arikan, and N. Delibalta. Comparison of three different treatment methods for generalized denture stomatitis. J Prosthet Dent1994; 72: 283-8.
 
[8]  Konsberg R. and T. Axell. Treatment of Candida-infected denture stomatitis with a miconazole lacquer. Oral Surgery, Oral Medicine, Oral Pathology1994; 78: 306-11.
 
[9]  Salerno C., M. Pascale, M. Contaldo et al. Candida-associated denture stomatitis. Medicina Oral Patologia Oral y Cirugia Bucal2011; 16: 139-43.
 
[10]  Budtz-Jorgensen E. and P. Carlino. A miconazole lacquer in the treatment of Candida-associated denture stomatitis. Mycoses. 1994; 37: 131-35.
 
[11]  Webb B. C., C. J. Thomas, M. D. P. Willcox, D. W. S. Harty, and K. W. Knox. Candida-associated denture stomatitis. Aetiology and management: a review. Part 3. Treatment of oral candidosis. Australian Dental Journal1998; 43: 244-9.
 
[12]  Santos V. R., F. J. G. S. Pimenta, M. C. F. Aguiar, M. A. V. Do Carmo, M. D. Naves, and R. A. Mesquita. Oral candidiasis treatment with Brazilian ethanol propolis extract. Phytotherapy Research2000; 19: 652-4.
 
[13]  Gendreau L. and Z. G. Loewy. Epidemiology and Etiology of Denture Stomatitis. J Prosthodo2011; 20: 251-60.
 
[14]  Casaroto A. R. and V. S. Lara. Phytomedicines for Candida-associated denture stomatitis. Fitoterapia2010; 81: 323-8.
 
[15]  Lamfon H., S. R. Porter, M. McCullough, and J. Pratten. Susceptibility of Candida albicans biofilms grown in a constant depth film fermentor to chlorhexidine, fluconazole and miconazole: a longitudinal study. Journal of Antimicrobial Chemotherapy2004; 53: 383-5.
 
[16]  Siqueira A. B. S., L. R. N. A. Rodriguez, R. K. B. Santos et al. Antifungal activity of propolis against Candida species isolated from cases of chronic periodontitis. Brazilian Oral Research. 2015; 29: 1-6.
 
[17]  Marcucci M. C. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie1995; 26: 83-99.
 
[18]  Stepanovic S., N. Antic, I. Dakic, and M. Svabic-Vlahovic. In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs. Microbiological Research. 2003, 158: 353-7.
 
[19]  Metzner J., E. M. Schneidewind, and E. Friedrich. On the effects of propolis and pinocembrin on blastomyces. Phar- mazie. 1977; 32: 730.
 
[20]  Tavares D. C., J. M. Senedese, A. R. Rodrigues et al. Assessment of the mutagenic activity of extracts of Brazilian propolis in topical pharmaceutical formulations on mammalian cells in vitro and in vivo. Evidence-based Complementary and Alternative Medicine2011; 2011.
 
[21]  Reis C. M. F., J. C. T. Carvalho, L. R. G. Caputo et al. Atividade antiinflamatória, antiúlcera gástrica e toxicidade subcrônica do extrato etanólico de propolis. Revista Brasileira de Farmacognosia. 2000; 9: 43-52.
 
[22]  MacHado J. L., A. K. M. Assunção, M. C. P. Da Silva et al. Brazilian green propolis: Anti-inflammatory property by an immune-modulatory activity. Evidence-Based Complementary and Alternative Medicine2012; 2012: 157652-62.
 
[23]  De Barros M. P., J. P. B. Sousa, J. K. Bastos, and S. F. de Andrade. Effect of Brazilian green propolis on experimental gastric ulcers in rats. Journal of Ethnopharma cology 2007; 110: 567-71.
 
[24]  Rocha B. A., M. R. Rodrigues, P. C. P. Bueno et al. Preparation and thermal characterization of inclusion complex of Brazilian green propolis and hydroxypropyl-β-cyclodextrin: increased water solubility of the chemical constituents and antioxidant activity. Journal of Thermal Analysis and Calorimetry. 2012; 108: 87-94.
 
[25]  Berretta A. A., A. P. Nascimento, P. C. P. Bueno, M. M. D. O. L. Leite Vaz, and J. M. Marchetti, “Propolis standardized extract (EPP-AF ®), an innovative chemically and biologically reproducible pharmaceutical compound for treating wounds. International Journal of Biological Sciences2012; 8: 512-21.
 
[26]  De Castro P. A., M. Savoldi, D. Bonatto et al. Molecular characterization of propolis-induced cell death in Saccharomyces cerevisiae. Eukaryotic Cell 2011; 10: 398-411.
 
[27]  Capistrano H. M., E. M. De Assis, R. M. Leal, M. E. Alvarez-Leite, S. Brener, and E. M. A. F. Bastos. Brazilian green propolis compared to miconazole gel in the treatment of Candida-associated denture stomatitis. Evidence-based Complementary and Alternative Medicine 2013; 2013: 947980-6.
 
[28]  Santos V. R., F. J. G. S. Pimenta, M. C. F. Aguiar, M. A. V. Do Carmo, M. D. Naves, and R. A. Mesquita. Oral candidiasis treatment with Brazilian ethanol propolis extract. Phytotherapy Research2005; 19: 652-4.
 
[29]  Azevedo R. V. P., M. C. Komesu, R. C. Candido, C. Salvetti, and F. H. C. Rezende. Candida sp in the oral cavity with and without lesions: maximal inhibitory dilution of propolis and periogard. Journal of Microbiology1999; 30: 335-41.
 
[30]  Berretta A. A., P. A. De Castro, A. H. Cavalheiro et al. Evaluation of mucoadhesive gels with propolis (EPP-AF) in preclinical treatment of candidiasis vulvovaginal infection. Evidence-Based Complementary and Alternative Medicine2013; 2013: 641480-98.
 
[31]  Santos V. R., R. T. Gomes, R. A. De Mesquita et al. Efficacy of brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytotherapy Research2008; 22: 1544-7.
 
[32]  Byadarahally Raju S and S. Rajappa. Isolation and identification of Candida from the oral cavity. ISRN Dentistry 2011; 2011: 487921-8.
 
[33]  Godoy J. S. R., P. De Souza Bonfim-Mendonça, S. S. Nakamura et al. Colonization of the oral cavity by yeasts in patients with chronic renal failure undergoing hemodialysis. Journal of Oral Pathology and Medicine2013; 42: 229-34.
 
[34]  Samaranayake L. P., T. W. MacFarlane, P. J. Lamey, and M. M. Ferguson. A comparison of oral rinse and imprint sampling techniques for the detection of yeast, coliform and Staphylococcus aureus carriage in the oral cavity. Journal of Oral Pathology. 1986; 15: 386-8.
 
[35]  Bianchi C. M. P. D. C., H. A. Bianchi, T. Tadano et al. Factors related to oral candidiasis in elderly users and non-users of removable dental prostheses. Revista do Instituto de Medicina Tropical de Sao Paulo2016; 58, 6-10.
 
[36]  Dutcoscky S., Food Sensory Analysis, Curitiba, 2nd edition, 2007.
 
[37]  Chow S., J. Shao, and H. Wang. Sample Size Calculations in Clinical Research, CRC Press, New York, 1st edition, 2003.
 
[38]  Da Costa-Júnior F. M and A. C. B. Maia. Conceptions of hospitalized men about the relation between gender and health. Psicologia: Teoria e Pesquisa. 2009: 25; 55-63.
 
[39]  Gawryszewsky V. P., M. S. Koizumi, and M. H. P. De Mello-Jorge. Morbidity and mortality from external causes in Brazil. Cadernos de Saúde Pública. 2004; 20: 995-100.
 
[40]  Ribeiro P. M., C. Y. Kogaito, J. C. Junqueira, and A. O. C. Jorge. Isolation of Candida spp. with the use of chromogenic culture medium CHROMagar Candida. Brazilian Dental Science 2009; 12: 40-5.
 
[41]  Cabrini J., L. Fais, M. Compagnoni, F. Mollo Júnior, and L. Pinelli. Wear time and the quality of the complete dentures-a critical analysis. Brazilian Dental Science2008; 11: 78-85.
 
[42]  Gharechahi M., H. Moosavi, and M. Forghani, “Effect of surface roughness and materials composition,” Journal of Biomaterials and Nanobiotechnology2012; 3: 541-6.
 
[43]  Patil S., R. S. Rao, B. Majumdar, and S. Anil, “Clinical appearance of oral Candida infection and therapeutic strategies,” Frontiers in Microbiology2015; 6: 1-10.
 
[44]  Gonçalves L. F., D. R. da Silva Neto, R. F. Bonan, H. L. Carlo, and A. D. Batista, Hygiene of removable and partial dentures. Brazilian Journal of Health Sciences. 2011; 15: 87-94.
 
[45]  Gouveia C. L., I. C. Freire, M. L. Leite et al. Antifungal activity of components used for decontamination of dental prostheses on the growth of Candida albicans. Journal of Dentistry of UNESP2014; 43: 137-142, 2014.
 
[46]  Longhini R., S. M. Raksa, A. C. Oliveira, T. I. Svidzinski, and S. L. Franco. Obtaining extracts of propolis under different conditions and evaluating their antifungal activity.Brazilian Journal of Pharmacognosy2007; 17: 388-95.
 
[47]  Zhang L.W., J.-Y. Fu, H. Hua, and Z.-M. Yan. Efficacy and safety of miconazole for oral candidiasis: a systematic review and meta-analysis, Oral Diseases2016; 22: 185-95.
 
[48]  Dalazen D., D. Zanrosso, L. Wanderley, N. L. Silva, and A. M. Fuentefria. Comparison of the susceptibility profile among clinical isolates of Candida spp. oral and vulvovaginal in Southern Brazil. Brazilian Journal of Pathology and Laboratory Medicine, 2011; 47: 33-8.
 
[49]  De Castro P. A., V. L. P. Bom, N. A. Brown et al. Identification of the cell targets important for propolis-induced cell death in Candida albicans. Fungal Genetics and Biology2013; 60: 74-86.