International Journal of Dental Sciences and Research
ISSN (Print): 2333-1135 ISSN (Online): 2333-1259 Website: http://www.sciepub.com/journal/ijdsr Editor-in-chief: Marcos Roberto Tovani Palone
Open Access
Journal Browser
Go
International Journal of Dental Sciences and Research. 2018, 6(1), 1-5
DOI: 10.12691/ijdsr-6-1-1
Open AccessArticle

Efficacy of NSAID (Lornoxicam) After Impacted Third-Molar Surgery With/Without Conscious Sedation: A Double-Blind Randomized Clinical Study

Ozkan Ozgul1, and Selahattin Or2

1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kirikkale University, Kirikkale, Turkey

2Department of Oral and maxillofacial Surgery, Faculty of Dentistry, Ankara University, Ankara, Turkey

Pub. Date: January 09, 2018

Cite this paper:
Ozkan Ozgul and Selahattin Or. Efficacy of NSAID (Lornoxicam) After Impacted Third-Molar Surgery With/Without Conscious Sedation: A Double-Blind Randomized Clinical Study. International Journal of Dental Sciences and Research. 2018; 6(1):1-5. doi: 10.12691/ijdsr-6-1-1

Abstract

Aim: Pain and swelling following surgery for impacted third molars can be controlled by various methods. This study compared the analgesic and anti-inflammatory efficacy and tolerability of lornoxicam, aspirin and a placebo with and without conscious sedation in impacted mandibular third-molar surgery. Materials and Methods: 60 patients undergoing third-molar surgery were divided into 2 groups of conscious sedation and routine local anesthesia (n=30). Both groups were divided into three subgroups (n=10) that received either Lornoxicam, aspirin, or a placebo postoperatively. Results: In both the conscious sedation and local anesthesia groups, swelling reduction was significantly greater with Lornoxicam compared to aspirin and placebo (p< .05). Pain values were significantly lower for Lornoxicam group compared to both aspirin and placebo groups at 6, 12 and 24 hours postoperatively (p< .05). Conclusion: Conscious sedation resulted less pain and swelling. Moreover, Lornoxicam was found to be an effective analgesic and anti-inflammatory agent for use in conjunction with oral surgery.

Keywords:
conscious sedation third molar surgery NSAID swelling pain clinical research

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Malamed, S.F, Conscious sedation and general anesthesia techniques and drugs used in dentistry, Anesth prog., 33, 176-178, 1986.
 
[2]  Ong, K.S., Seymour, A., Tan, H, Sedation with midazolam leads to reduced pain after dental surgery, Anesth analg.,98, 1289-1293, 2004.
 
[3]  Archer, W.H, Oral and Maxillofacial Surgery, fifth ed., Saunders Company Philadelphia, 1975.
 
[4]  Amin, M.M., Laskin, D.M, Prophylactic use of indomethacin for prevention of postsurgical complications after removal of impacted third molars. Oral Surg Oral Med Oral Pathol., 55, 448-451, 1983.
 
[5]  Kay, B., Total intravenous anaesthesia. Elsevier Science Publishers, Amsterdam. 1991.
 
[6]  Bagan, J.V., Lopez, J.S., Valencia, E, Clinical comparison of dexketoprofen trometamol and dipyrone in postoperative dental pain, J clin pharmacol,. 38, 55-64, 1998.
 
[7]  Björnsson, G.A., Haanaes, H.R., Skoglund, L.A, Naproxen 500 mg bid versus acetaminophen 1000 mg qid: effect on swelling and other acute postoperative events after bilateral third molar surgery, J. Clin pharmacol.,43, 849-858, 2003.
 
[8]  Spilka, C.J, The placebo of corticosteroids and antihistamines in oral surgery, Oral Surg Oral Med Oral Pathol., 14, 1034-1042, 1961.
 
[9]  Mowafi, H.A., Elmakarim, E.A., Ismail, S., Al-Mahdy, M., El-Saflan, A.E., Elsaid, A.S, Intravenous lornoxicam is more effective than paracetamol as a supplemental analgesic after lower abdominal surgery: a randomized controlled study, World J Surg.,36, 2039-2044, 2012
 
[10]  Zor, Z.F., Isık. Z., Cetiner S, Efficacy of preemptive lornoxicam on postoperative analgesia after surgical removal of mandibular third molars. Oral Surg Oral Med Oral Pathol Oral Radiol, 117, 27-31, 2014.
 
[11]  López-Ramírez, M., Vílchez-Pérez, M.A., Gargallo-Albiol, J., Arnabat-Domínguez, J., Gay-Escoda, C, Efficacy of low-level laser therapy in the management of pain, facial swelling, and post- operative trismus after a lower third molar extraction: a preliminary study, Laser Med Sci., 27, 559-566, 2012.
 
[12]  Colarado-Bonnin, M., Valmeseda-Castellon, E., Berini-aytes, L., Gay-Escoda, C, Quality of life following lower third molar removal, Int. J oral Maxillofac Surg., 35, 343-347, 2004.
 
[13]  Penarrocha, M., Sanchis, J.M., Saez, U., Gay, C., Bagán J.V, Oral hygiene and postoperative pain after mandibular third molar surgery. Oral surg. Oral med. Oral pathol. Oral. Radiol. Endod., 92, 260-264, 2001.
 
[14]  Jimenez-martinez, E., Gasco-garcia. C., Arrieta-blanco. J.J., Gomez del Torno, J., Bartolome Villar, B, Study of the analgesic efficacy of dexketoprofen trometamol 25mg vs. Ibubprofen 600 mg after their administration in patients subjected to oral surgery, Med oral., 9, 138-148, 2004.
 
[15]  Seymour, R.A., Blair, G.S., Wyatt, F.A, Postoperative dental pain and analgesic efficacy. Part 1, Br J Oral Surg., 21, 290-297, 1983.
 
[16]  Macgregor, A.J., Addy, A, Value of penicilin in the prevention of pain swelling and trismus and following the removal of ectopic mandibular third molars. Int J Oral Surg., 9, 166-171, 1980.
 
[17]  Coulthard, P., Haywood, D., Tai, M.A., Jackson-Leech, D., Pleuvry, B.J., Macfarlane, T.V, Treatment of postoperative pain in oral and maxillofacial surgery. Br J Oral Maxillofac Surg., 38, 588-592, 2000.
 
[18]  Lau, S.L., Chow, R.L., Yeung, R.W., Samman, N, Preemptive ibuprofen arginate in third molar surgery: a double-blind randomized controlled crossover clinical trial. Aust Dent J., 54, 355-360, 2009.
 
[19]  Markovic, A.B., Todorovic, L, Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 102, 4-8, 2006.
 
[20]  Seymour, R.A., Meechan, J.G., Blair, G.S, An investigation into postoperative pain after third molar surgery under local analgesia. Br J Oral Maxillofac Surg., 23, 410-418, 1985.
 
[21]  Coulthard, P., Rood, J.P, An investigation of the effect of midozolam on the pain experience. Br J Oral Maxillofac Surg., 30, 248-251, 1992.
 
[22]  Lustenberger, F.D., Grätz, K.W., Mutzbauer, T.S, Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study, Oral maxillofacial Surg., 15, 62-67, 2011.