Prevalence and Incidence of Orofacial Cleft Anomalies in Children with Cleft Lip and Palate Associated with Etiological Deformities in Hail Region, Saudi Arabia

Abdullah Faraj AlShammari¹, Dalal Habib AlShammary¹, Hasna Rasheed Alshubrmi¹, Ebtsam Abdullah Aledaili², Hazza Abdullah Alhobeira¹ and Hussain Gadelkarim Ahmed^3,

¹College of Dentistry, University of Hail, Kingdom of Saudi Arabia (KSA)

²Ministry of Health, University of Hail

³College of Medicine, University of Hail

Cite this paper:
Abdullah Faraj AlShammari, Dalal Habib AlShammary, Hasna Rasheed Alshubrmi, Ebtsam Abdullah Aledaili, Hazza Abdullah Alhobeira and Hussain Gadelkarim Ahmed. Prevalence and Incidence of Orofacial Cleft Anomalies in Children with Cleft Lip and Palate Associated with Etiological Deformities in Hail Region, Saudi Arabia. International Journal of Dental Sciences and Research. 2017; 5(6):141-145. doi: 10.12691/ijdsr-5-6-2

Abstract

Aim: The aim of this study was to explore the prevalence, incidence and possible etiological risk factors of orofacial cleft in Hail Region, Northern Saudi Arabia. Methodology: This is a retrospective study conducted in Maternity Hospital, Hail, Saudi Arabia. Data of seven years (2011-2017) records of newborn infants were reviewed for the presence of orofacial anomalies (included 27800 files). Results: The overall prevalence rate of orofacial cleft was 1.08 per 1000 births. Out of 30 patients diagnosed with orofacial anomalies, 14(46.7%) were found with cleft palate, 11(36.7%) with bilateral cleft lip and palate, 4(13.3%) with bilateral cleft lip and only one (3.3%) with unilateral cleft lip and palate. Conclusion: The prevalence of orofacial clefts in Northern Saudi Arabia was similar or slightly lower than the higher global reported rates. Cleft palate was the most common type of orofacial cleft in Northern Saudi Arabia.

Keywords:
orofacial cleft cleft palate cleft lip orofacial anomalies Saudi Arabia

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References:

[1]	CDC. Facts about Cleft Lip and Cleft Palate 2017. Retrieved 2017. Available at: https: //www.cdc.gov/ncbddd/birthdefects/cleftlip.html.
[2]	CDC. Birth defect. Facts about Cleft Lip and Cleft Palate 2017. Retrieved 2017. Available at: https: //web.archive.org/web/20150508162121/http: //www.cdc.gov/ncbddd/birthdefects/CleftLip.html.
[3]	Crockett DJ, Goudy SL. Cleft lip and palate. Facial Plast Surg Clin North Am. 2014 Nov; 22(4): 573-86.
[4]	Reiter R, Haase S, Brosch S. Orofacial clefts. Laryngorhinootologie 2012; 91(2): 84-95.
[5]	Parker SE, Mai CT, Canfield MA, Rickard R, Wang Y, Meyer RE, Anderson P, Mason CA, Collins JS, Kirby RS, Correa A; for the National Birth Defects Prevention Network. Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006. Birth Defects Research (Part A): Clinical and Molecular Teratology 2010; 88: 1008-16.
[6]	Little J, Cardy A, Munger RG. Tobacco smoking and oral clefts: a meta-analysis. Bull World Health Organ. 2004; 82: 213-18.
[7]	Honein MA, Rasmussen SA, Reefhuis J, Romitti P, Lammer EJ, Sun L, Correa A. Maternal smoking, environmental tobacco smoke, and the risk of oral clefts. Epidemiology 2007; 18: 226-33.
[8]	Yazdy MM, Autry AR, Honein MA, Frias JL. Use of special education services by children with orofacial clefts. Birth Defects Research (Part A): Clinical and Molecular Teratology 2008; 82: 147-54.
[9]	Jiang R, Bush JO, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006; 235(5): 1152-66.
[10]	Steegers-Theunissen RP, Steegers EA. Nutrient-gene interactions in early pregnancy: a vascular hypothesis. Eur J Obstet Gynecol Reprod Biol. 2003; 106(2): 115-7.
[11]	Wyszynski DF, Beaty TH. Review of the role of potential teratogens in the origin of human nonsyndromic oral clefts. Teratology. 1996 May; 53(5): 309-17.
[12]	Reefhuis J, de Jong-van den Berg LT, Cornel MC. The use of birth defect registries for etiological research: a review. Community Genet. 2002; 5(1): 13-32.
[13]	Krapels IP, Zielhuis GA, Vroom F, et al. Periconceptional health and lifestyle factors of both parents affect the risk of live-born children with orofacial clefts. Birth Defects Res A Clin Mol Teratol. 2006 Aug; 76(8): 613-20.
[14]	Shaw GM, Wasserman CR, Lammer EJ, O'Malley CD, Murray JC, Basart AM, Tolarova MM. Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants. Am J Hum Genet. 1996 Mar; 58(3): 551-61.
[15]	Murray JC. Gene/environment causes of cleft lip and/or palate. Clin Genet. 2002 Apr; 61(4): 248-56.
[16]	Brender JD, Zhan FB, Suarez L, Langlois PH, Moody K. Maternal residential proximity to waste sites and industrial facilities and oral clefts in offspring. J Occup Environ Med. 2006 Jun; 48(6): 565-72.
[17]	Wang W, Guan P, Xu W, Zhou B. Risk factors for oral clefts: a population-based case-control study in Shenyang, China. Paediatr Perinat Epidemiol. 2009 Jul; 23(4): 310-20.
[18]	Watkins SE, Meyer RE, Strauss RP, Aylsworth AS. Classification, epidemiology, and genetics of orofacial clefts. Clin Plast Surg. 2014; 41(2): 149-63.
[19]	IPDTOC Working Group: Prevalence at birth of cleft lip with or without cleft palate: data from the International Perinatal Database of Typical Oral Clefts (IPDTOC). Cleft Palate Craniofac J. 2011; 48(1): 66-81.
[20]	Allagh KP, Shamanna BR, Murthy GV, et al.. Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis. PLoS One. 2015; 10(3): e0118961.
[21]	Butali A, Adeyemo WL, Mossey PA, et al.: Prevalence of orofacial clefts in Nigeria. Cleft Palate Craniofac J. 2014; 51(3): 320-5.
[22]	Burg ML, Chai Y, Yao CA, Magee W, Figueiredo JC. Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Frontiers in Physiology. 2016; 7: 67.
[23]	Sabbagh HJ, Innes NP, Sallout BI, et al. Birth prevalence of non-syndromic orofacial clefts in Saudi Arabia and the effects of parental consanguinity. Saudi Medical Journal. 2015; 36(9): 1076-1083.
[24]	Ravichandran K, Shoukri M, Aljohar A, Shazia NS, Al-Twaijri Y, Al Jarba I. Consanguinity and occurrence of cleft lip/palate: a hospital-based registry study in Riyadh. Am J Med Genet A. 2012; 158A(3): 541-6.
[25]	Sabbagh HJ, Hassan MH, Innes NP, Baik AA, Mossey PA. Parental consanguinity and nonsyndromic orofacial clefts in children: a systematic review and meta-analyses. Cleft Palate Craniofac J. 2014; 51(5): 501-13.
[26]	Berg E, Lie RT, Sivertsen Å, Haaland ØA. Parental age and the risk of isolated cleft lip: a registry-based study. Ann Epidemiol. 2015; 25(12): 942-7. e1.
[27]	Little J, Cardy A, Munger RG. Tobacco smoking and oral clefts: a meta-analysis. Bulletin of the World Health Organization. 2004; 82(3): 213-218.
[28]	Brooklyin S, Jana R, Aravinthan S, Adhisivam B, Chand P. Assessment of Folic Acid and DNA Damage in Cleft Lip and Cleft Palate. Clinics and Practice. 2014; 4(1): 608.
[29]	Murthy GVS, Kolli SR, Neogi SB, et al. A Mixed-Method Study to Determine the Benefits of Periconceptional Folic Acid Supplementation and Effects of Folic Acid Deficiency in Mothers on Birth Outcomes. Eysenbach G, ed. JMIR Research Protocols. 2016; 5(2): e129.
[30]	Hozyasz K, Chełchowska M, Surowiec Z. Plasma vitamin A in mothers of children with orofacial clefts. Ginekol Pol. 2004; 75(2): 139-44.