International Journal of Dental Sciences and Research
ISSN (Print): 2333-1135 ISSN (Online): 2333-1259 Website: http://www.sciepub.com/journal/ijdsr Editor-in-chief: Marcos Roberto Tovani Palone
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International Journal of Dental Sciences and Research. 2015, 3(2A), 15-25
DOI: 10.12691/ijdsr-3-2A-4
Open AccessResearch Article

Dental Stem Cells: A Perspective Area in Dentistry

Sura Ali Ahmed Fouad1,

1Associate Dean College of Dentistry, Gulf Medical University, Ajman /UAE

Pub. Date: March 15, 2015
(This article belongs to the Special Issue Journal of Oral Biological Research and Review)

Cite this paper:
Sura Ali Ahmed Fouad. Dental Stem Cells: A Perspective Area in Dentistry. International Journal of Dental Sciences and Research. 2015; 3(2A):15-25. doi: 10.12691/ijdsr-3-2A-4

Abstract

In recent years, stem cell research has grown exponentially due to the recognition that stem cell-based therapies have the potential to improve the life of patients with wide range of conditions, they provides promising methods in vitro as well as in vivo in animal models which make speculation about a future application in human dentistry reasonable. Based on their ability to repair and/or rescue injured tissue and restore organ function even partially, multiple types of stem/progenitor cells have been speculated. Some dental tissues are rich source of mesenchymal stem cells which are suitable for tissue engineering applications. Because they have the potential to differentiate into several cell types, including odontoblasts, neural progenitors, osteoblasts, chondrocytes, and adipocytes. Based on that, an innovativation for generation of clinical material and/or tissue regeneration carried out. Mesenchymal stem cells were founded in dental tissues, including dental pulp, dental papilla, and dental follicle, exfoliated deciduous teeth and periodontal ligament. They can be isolated and grown under defined tissue culture conditions, and used in tissue engineering, including, dental tissue, nerves and bone regeneration.

Keywords:
regeneration stem cells periodontal tissues cloning mesenchymal cells

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References:

[1]  Sumit Narang, NidhiSehgal. Stem cells: A potential regenerative future in dentistry. 2012; 18: 2: 150-154.
 
[2]  Emilia Lopez. Three Types of Cloning and the Necessity to Regulate. UCSC Center for Biomolecular Science & Engineering—Page 2 of 4. http://www.whitehouse.gov/news/releases/2001/08/print/20010809-1
 
[3]  Kennedy, Donald. 2003. Stem Cells: Still Here, Still Waiting. Science 300: 865.
 
[4]  E. Phimister and J. Drazen. Two Fillips for Human Embryonic Stem Cells.” New England Journal of Medicine 2004; 350: 1351-1352.
 
[5]  Bjorklund, L. M., R. Sanchez-Pernaute, et al. “Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model.” Proceedings of the National Academy of Sciences 2002; 99: 2344-2349.
 
[6]  Hunter, Philip. Differentiating Hope from Embryonic Stem Cells. The Scientist. 2003; 17: 31.
 
[7]  Draper, J.S., et al., “Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells,” Nature Biotechnology December 7, 2003, advance online publication.
 
[8]  C. Cowan et al. Derivation of Embryonic Stem-Cell Lines from Human Blastocysts. New England Journal of Medicine 2004; 350: 1353-1356.
 
[9]  Franziska L. Ulmer; Andreas Winkel; Philipp Kohorst; Meike Stiesch. Stem Cells-Prospects in Dentistry. Schweiz Monatsschr Zahnmed. 2010; 120: 10.
 
[10]  S. Gronthos, M. Mankani, J. Brahim, P. GehronRobey, and S. Shi Postnatal human dental pulp stem cells (DPSCs) in vitro and invivo.PNAS December 5, 2000; 97: 25: 13625-13630.
 
[11]  Miura M, Gronthos S, Zhao M, Lu B, Fisher L W,Robey P G, Shi S: SHED: stem cells from humanexfoliated deciduous teeth. Proc Natl Acad Sci. U S A2003; 100: 5807-5812. (2003).
 
[12]  Seo BM, Miura M, Gronthos S, Bartold PM, BatouliS, Brahim J, Young M, Robey PG, Wang CY, Shi. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004; 364: 149-155.
 
[13]  SonoyamaWataru, Yi Liu, Takayoshi Yamaza, Rocky S. Tuan, Songlin Wang, Songtao Shi, and George T.-J. Huang. Characterization of Apical Papilla and its Residing Stem Cells from Human Immature Permanent Teeth-A Pilot Study.-J Endod. 2008; 34(2): 166-171.
 
[14]  Morsczeck C, Moehl C, Gotz W, Heredia A, Schaffer T E, Eckstein N, Sippel C, Hoffmann K H: In vitro differentiation of human dental follicle cells with dexamethasone and insulin. Cell Biol Int (2005). 29: 567-575.
 
[15]  Ming Chen, Hai-Hua Sun, Hong Lu, Qing Yu. Stem cell-delivery therapeutics for periodontal tissue regeneration. Biomaterials. 2012; 33, 27, 6320-6344.
 
[16]  Carlos ESTRELA, Ana Helena Gonçalves de ALENCAR, Gregory Thomas KITTEN, Eneida Franco VENCIO, Elisandra GAVA. Mesenchymal Stem Cells in the Dental Tissues: Perspectives for Tissue Regeneration. Braz Dent J 2011; 22 (2): 91-98.
 
[17]  Masako Miura, Stan Gronthos, Mingrui Zhao‡, Bai Lu, Larry W. Fisher, Pamela GehronRobey, and Songtao ShiSHED: Stem cells from human exfoliated deciduous teeth.PNAS _ 2003; 100 (10); 5807-5812.
 
[18]  Xi Wing, Xin-Jia Sha, Guang-Hui Li, Fu-Sheng Yang, Kun Ji, Ling-Ying Wen, Shi-Yu Liu, Lei Chen, Yin Ding. Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells. Archives of Oral Biology 2012:57, 9. 1231-1240.
 
[19]  Batouli S, Miura M, Brahim J, Tsutsui T W, Fisher L W, Gronthos S, Robey P G, Shi S: Comparison of stem-cell-mediated osteogenesis and dentinogenesis. J Dent Res 2003; 82: 976-981.
 
[20]  Xiao-Ying Zou,Hisao-Ying Yang,Zongdong Yu,et al. Establishment of transgene-free induced pluripotent stem cells reprogrammed from human stem cells of apical papilla for neural differentiation.Stem cell research and therapy 2012;3:43.
 
[21]  M. Melcher, Anal. Chim. Acta 1983; I53, 297-300.
 
[22]  Yamada Y, Matsuuo H, Segawa T, Assessment of genetic risk for myocardial infection. Thromb Haemost. 2006; 96, 220-227.
 
[23]  Liu Y, Zheng Y, Ding G, Fang D, Zhang C, Bartold P M, Gronthos S, Shi S, Wang S: Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells 2008); 26: 1065-1073.
 
[24]  Masayuki Yamato, Teruo Okano. Materials today. Cell sheet engineering 2004; 7: (5), 42-7.
 
[25]  Kerstin M. Galler, Rena N. D'Souza, and Jeffrey D. Hartgerink. Biomaterials and their potential applications for dental tissue engineering. J. Mater. Chem., 2010, 20, 8730-8746.
 
[26]  Rachel Sartaj and Paul Sharpe. Biological tooth replacement. J Anat. 2006; 209 (4): 503-509.
 
[27]  Otto F, Thornell AP, Crompton T, et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997; 89: 765-771.
 
[28]  Robey PG. Post-natal stem cells for dental and craniofacial repair. Oral Biosci Med. 2005;2: 83-90.
 
[29]  Young CS, Terada S, Vacanti JP, et al. Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res. 2002;10: 695-700.
 
[30]  Duailibi MT, Duailibi SE, Young CS, et al. Bioengineered teeth from cultured rat tooth bud cells. J Dent Res. 2004;83:523-528.
 
[31]  Ohazama A, Modino SAC, Miletich I, et al. Stem-cell-based tissue engineering of murine teeth. J Dent Res. 2004;83: 518-522.
 
[32]  Myers WC, Fountain SB Dental pulp regeneration aided by blood and blood substitutes after experimentally induced periapical infection. Oral Surgery Oral Medicine Oral Pathology. 1974; 37, 441-50.
 
[33]  Gu K, Smoke RH, Rutherford RB. Expression of genes for bone morphogenetic proteins and receptors in human dental pulp. Arch Oral Biol. 1996; 41:919-923.
 
[34]  Mooney DJ, Powell C, Piana J, Rutherford B. Engineering dental pulp-like tissue in vitro. Biotechnol Prog. 1996; 12: 865-8.
 
[35]  Buurma B, Gu K, Rutherford RB. Transplantation of human pulpal and gingival fibroblasts attached to synthetic scaffolds. European Journal of Oral Sciences. 1999; 107: 282-9.
 
[36]  Huang GTJ, Sonoyama W, Chen J, Park S. In vitro characterization of human dental pulp cells: various isolation methods and culturing environments. Cell and Tissue Research. 2006; 324: 225-236.
 
[37]  Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative Endodontics: A Review of Current Status and a Call for Action. Journal of Endodontics. 2007; 33: 377-390.
 
[38]  Prescott RS, Alsanea R, Fayad MI, Johnson BR, Wenckus CS, Hao J, et al. In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod 2008; 34: 421-426.
 
[39]  Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, et al.. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod 2008; 34: 962-969.
 
[40]  Myers WC, Fountain SB. (1974). Dental pulp regeneration aided by blood and blood substitutes after experimentally induced periapical infection. Oral Surg Oral Med Oral Pathol 37: 441-450.