International Journal of Dental Sciences and Research
ISSN (Print): 2333-1135 ISSN (Online): 2333-1259 Website: http://www.sciepub.com/journal/ijdsr Editor-in-chief: Marcos Roberto Tovani Palone
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International Journal of Dental Sciences and Research. 2014, 2(4B), 7-10
DOI: 10.12691/ijdsr-2-4B-3
Open AccessResearch Article

Correlation between Circulatory and Salivary IL 10 Levels in Periodontal Health and Disease – A Report

Archana1, Sasireka2, M.N Prabhu3, Bobby2, and Venkata Srikanth2

1Department of Periodontics, Madha Dental College, Chennai,India

2Department of Periodontics, Adhiparasakthi Dental College, Melmaruvathur, India

3Departmentof Periodontics, Penang International Dental College, Malaysia

Pub. Date: August 18, 2014
(This article belongs to the Special Issue INTERNATIONAL JOURNAL OF ORAL BIOLOGICAL SCIENCES)

Cite this paper:
Archana, Sasireka, M.N Prabhu, Bobby and Venkata Srikanth. Correlation between Circulatory and Salivary IL 10 Levels in Periodontal Health and Disease – A Report. International Journal of Dental Sciences and Research. 2014; 2(4B):7-10. doi: 10.12691/ijdsr-2-4B-3

Abstract

Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell populations. Its main biological function seems to be the limitation and termination of inflammatory responses and the regulation of differentiation and proliferation of several immune cells such as T cells, B cells, natural killer cells, antigen-presenting cells, mast cells, and granulocytes. The present study has correlated the salivary IL-10 levels with that of the circulatory levels in periodontal health and diseased patients and also brings an attestation for Saliva as point of care diagnosis.

Keywords:
interleukins pro inflammatory cytokines anti inflammatory cytokines Th1 Th2 GCF

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References:

[1]  Allavena P, Piemonti L, Longoni D, Bernasconi S, Stoppacciaro A, Ruco L, and Mantovani A (1998) IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol 28: 359-369.
 
[2]  Andersen SR, Lambrecht LJ, Swan SK, Cutler DL, Radwanski E, Affrime MB, and Garaud JJ (1999) Disposition of recombinant human interleukin-10 in subjectswith various degrees of renal function. J Clin Pharmacol 39: 1015-1020.
 
[3]  Aoyagi T, Sugawara-Aoyagi M, Yamazaki K, Hara K. Interleukin 4 (IL-4) and IL-6-producing memory T-cells in peripheral blood and gingival tissue in periodontitis patients with high serum antibody titres to Porphyromonas gingivalis. Oral Micrbiol Immunol 1995; 10: 304± 10.
 
[4]  Aurer Andrej, Ksenija Jorgi-Srdjak, Darije Planak, Ana Stavljeni-Rukavina and Jelena Aurer-Ko elj Proinflammatory Factors in Saliva as PossibleMarkers for Periodontal Disease Coll. Antropol. 29 (2005) 2: 435-439
 
[5]  Chernoff AE, Granowitz EV, Shapiro L, Vannier E, Lonnemann G, Angel JB, Kennedy JS, Rabson AR, Wolff SM, and Dinarello CA (1995) A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. J Immunol 154: 5492-5499.
 
[6]  Cooper PJ, Fekade D, Remick DG, Grint P, Wherry J, and Griffin GE (2000) Recombinant human interleukin-10 fails to alter proinflammatory cytokine production or physiologic changes associated with the Jarisch-Herxheimer reaction. J Infect Dis 181: 203-209.
 
[7]  D’Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, and Trinchieri G (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessorycells. J Exp Med 178: 1041-1048.
 
[8]  Defrance T, Vanbervliet B, Briere F, Durand I, Rousset F, and Banchereau J (1992) Interleukin 10 and transforming growth factor beta cooperate to induce anti- CD40-activated naive human B cells to secrete immunoglobulin A. J Exp Med 175: 671-682.
 
[9]  Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, and Romagnani S (1993) Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 150: 353-360.
 
[10]  Delaleu N, Immervoll H, Cornelius J, Jonsson R. Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations. Arthritis Res Ther. 2008; 10(1): R22. Epub 2008 Feb 20.
 
[11]  Demangel C, Bertolino P, and Britton WJ (2002) Autocrine IL-10 impairs dendritic cell derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Eur J Immunol 32: 994-1002.
 
[12]  Ebersole JL, Taubman MA. The protective nature of host responses in periodontal diseases. Periodontol 2000, 1994; 5: 112-141.
 
[13]  Ebersole Jl,Cappelli D Acute phase reactants in infections and inflammatory diseases Periodontol 2000 2000; 23: 19-49.
 
[14]  Fujihashi K, Yamamoto M, Hiroi T, Bamberg TV, McGhee JR,Kiyono H. Selected Th-1 and Th-2 cytokine mRNA expression by CD4(1) T cells isolated from inflamed human gingival tissues. Clin Exp Immunol 1996; 103: 422±87.
 
[15]  Fukui M, Hinode D, Yokoyama M, Tanabe S, Yoshioka M Salivary immunoglobulin A directed to oral microbiology GroEL in patients with periodontitis and their potential protective role. Oral Microbiol Immunol 2006; 21:289-295.
 
[16]  Gallagher G, Dickensheets H, Eskdale J, Izotova LS, Mirochnitchenko OV, Peat JD,Vazquez N, Pestka S, Donnelly RP, and Kotenko SV (2000) Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Genes Immun 1:442-450.
 
[17]  Gemmell E, Marshall RI, Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal diseases. Periodontol 2000 1997; 14: 112±43.
 
[18]  Gemmell E, Seymour GJ. Cytokine profiles of cells extracted from humans with periodontal diseases. J Dent Res 1998; 77: 16±26.
 
[19]  Gemmell E, Seymour GJ. gd T lymphocytes in human periodontal disease tissue. J Periodontol 1995; 66: 780±5.
 
[20]  Gerard C, Bruyns C, Marchant A, Abramowicz D, Vandenabeele P, Delvaux A, Fiers W, Goldman M, and Velu T (1993) Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 177: 547-550.
 
[21]  Giannobile WV, Al-Shammari KF, Sarment DP. Matrix molecules and growth factors as indicators of periodontal disease activity. Periodontol 2000 2003: 31: 125-134.
 
[22]  Giannobile WV, Beikler T, Kinney JS, Ramseier CA, Morelli T, Wong DT. Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000. 2009; 50: 52.
 
[23]  Hart TC, Marazita ML, Schenkein HA, Brooks CN, Gunsolley JG,Diehl SR. No female preponderance in juvenile periodontitis after correction for ascertainment bias. J Periodontol 1991; 62: 745±9.
 
[24]  Jenkins JK, Malyak M, and Arend WP (1994) The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophiles. Lymphokine Cytokine Res 13: 47-54.
 
[25]  Lappin DF, Koulouri O, Radvar M, Hodge P, Kinane DF. Relative proportions of mononuclear cell types in periodontal lesions analyzed by immunohistochemistry. J Clin Periodontol 1999; 26: 183±9.
 
[26]  Manhart SS, Reinhardt RA, Payne JB, Seymour GJ, Gemmell E, Dyer JK, Petro TM. Gingival cell IL-2 and IL-4 in early onset periodontitis. J Periodontol 1994; 144: 662Ð6.
 
[27]  Miller, Foley JD, Bailey AL, Campell CL, Humphries RL, Christodoulides N, Floriano PN, Simmons G, Bhagwandin B, Jacobson JW, Redding SW, Ebersole JL, McDevitt JT. Current developments in salivary diagnostics.Biomark Med. 2010; 4(1): 171-89.
 
[28]  Morse HR, Bidwell JL, and Raveche ES (1999) A poly(C) repeat polymorphism in the promoter of the IL-10 gene in NZB mice. Eur J Immunogenet 26: 377-378.
 
[29]  Nagai A, Takahashi K, Sato N et al. Abnormal proportion of gd T cells in peripheral blood is frequently detected in patients with periodontal disease. J Periodontol 1993; 64: 963±7.
 
[30]  Offenbacher S, Slade GD Beck JD, Heiss G, Pankow JS. Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res. 2000; 79(1): 49-57.
 
[31]  Offenbacher, S.P.Barros, R.E.Singer, K.Moss, R.C. Williams, J.D. Beck. Periodontal disease at the biofilm-gingival interface. Journal of Periodontology.2007; 78: 1911-1925.
 
[32]  Ritter M, Buechler C, Langmann T, Orso E, Klucken J, and Schmitz G (1999) The scavenger receptor CD163: regulation, promoter structure and genomic organization.Pathobiology 67: 257-26.
 
[33]  Takahashi K, Poole I, Kinane DF. Detection of interleukin-1b mRNAexpressing cells in gingival crevicular fluid by in situ hybridization. Arch Oral Biol 1995; 40: 941±7.
 
[34]  Yamazaki K, Nakajima T, Hara K. Immunohistological analysis of T cell functional subsets in chronic inflammatory periodontal disease. Clin Exp Immunol 1995; 99: 384±91.