Calcifying Epithelial Odontogenic Tumor of Jaw; A Review (Distinct Pathognomic Diagnostic (LRs)profile of Pindborg tumor)

Naveed A. Khawaja^{1, 2,}

¹Faculty, Maxillofacial Surgery and Diagnostic Science, College of Dentistry, King Saud University, Riyadh

²Former Assistant Professor / HOD Oral Pathology Department. Dental Section, Nishtar Medical College, Multan-Pakistan

Cite this paper:
Naveed A. Khawaja. Calcifying Epithelial Odontogenic Tumor of Jaw; A Review (Distinct Pathognomic Diagnostic (LRs)profile of Pindborg tumor). International Journal of Dental Sciences and Research. 2020; 8(4):102-104. doi: 10.12691/ijdsr-8-4-5

Abstract

Calcifying epithelial odontogenic tumor (CEOT) is a benign epithelial odontogenic tumor which is characterized by the presence of islands and sheets of epithelial cells, amyloid like material and calcifications. These calcifications have a concentric lamellar pattern known as “Liesegang Rings” (LRs). So far It is highlighted that LRs developed mostly in intraosseous lesions having amyloid like materials which later transformed to calcification. Many variants of histopathology discussed in this article to emphasize importance of calcification in CEOT. Although LRs are considered to be pathognomic to CEOT when it comes to odontogenic lesions, this term has sometimes been used for adenomatoid odontogenic tumor (AOT) where concentric lamellar calcifications have also been reported. However, here question arises, are LiesegangRings the misnomer in calcifying epithelial odontogenic tumor? Yes, at some aspects on basis of the different etiology, the appearance, and staining patterns. To conclude in view of literatures that phenomena of “Liesegang ring pattern of calcification” is to be more appropriate found in odontogenic tumors.

Keywords:
CEOT Liesegang Rings (LRs) calcification

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References:

[1]	Araujo V, Chagas JF, Casonato H, Ribeiro AL, Toledo JI. Calcifying epithelial odontogenic tumor. A case report with 3-year follow up. Int J Dent, 2011,10,195-199.
[2]	Afroz N, Jain A, Maheswari V, Ahmad SS. Non-calcifying variant of calcifying epithelial odontogenic tumor with clear cells-first case report of an extraosseous (peripheral) presentation. Eur J Gen Dent, 2013, 2, 80-82.
[3]	Shafer WG, Hine MK, Levy BM, editors. A textbook of oral pathology.4. Philadelphia: WB Saunder Comp, 1983, 286-269.
[4]	Kramer IR, Pindborg JJ, Shear M. Histological typing of odontogenic tumours. Germany: Spring-Verlag Berlin Heidelberg,1992, 15.
[5]	Sharma U, Gulati A, Batra H, Singh D. Calcifying Epithelial Odontogenic Tumor in anterior maxilla associated with supernumerary tooth: A case report. J Dent Res Clin Dent Prospects, 2013, 7(1), 51-54.
[6]	Bangalore Rahim Ahmed Mujib, PavanGurunathrao Kulkarni, Ashok Lingappo, Abhishek Jahagridar and CristalleSoman. Atypical presentation of Pindborg tumor in anterior maxilla. Dent Res J, 2012, 9(4), 495-498.
[7]	Phipsen HP, Reichart PA. Calcifying epithelial odontogenic tumour: biological profile based on 181 cases from literature. Oral Oncol, 2000, 36, 17-26.
[8]	Islam MT, Ou JJ, Hansen K, Simon RA, Quddus MR. Lieseganglike rings in lactational changes in the breast. Case Rep Pathol, 2012, 2012, 268903.
[9]	Padwell A. Liesegang rings associated with a cystic lesion of the eyelid. Br J Ophthalmol,1995, 79, 706-7.
[10]	Bhat SP, Prasad KH, Ravinder P, Hegde P. Liesegang rings: An unusual mimicker in renal cyst. Int J Health Allied Sci, 2013, 2, 139-40.
[11]	Todd TD, Dhurandhar B, Mody D, Ramzy I, Truong LD. Fine needle aspiration of cystic lesions of the kidney. Morphologic spectrum and diagnostic problems in 41 cases. Am J ClinPathol, 1999, 111, 317-28.
[12]	Pindborg JJ. Calcifying epithelial odontogenic tumour. ActaPatholMicrobiolScand, 1955, 7, 111.
[13]	Pindborg JJ. A calcifying odontogenic tumor.Cancer, 1958,11, 838-43.
[14]	Chaudhry AP, Holte NO, Vickers RA. Calcifying epithelial odontogenic tumour: report of a case. Oral Surg Oral Med Oral Pathol,1962, 15, 843-7.
[15]	Siar CH, Ng KH. The combined epithelial odontogenic tumor in Malaysians. Br J Oral MaxillofacSurg,1991,29, 106-9
[16]	Patino B, Fernandez-Alba J, Garcia-Rozado A, Martin R, Lopez-Cedrun JL, Sanroman B. Calcifying epithelial odontogenic (pindborg) tumour; a series of 4 distinct cases and a review of literature. J Oral Maxillofac Surg, 2005, 63, 1361-68
[17]	AchilleTarsitano, , , The diagnostic and surgical management of a multifocal calcifiyng epithelial odontogenic tumor in the mandible and maxilla associated with a squamous odontogenic tumor: first reported case in the literature. Oral Surg Oral Med Oral Pathol Oral Rad, 2012, 113(4), e6-e11.
[18]	Vinayakrishne K, Soumithran CS, Sobhana CR, Biradar V. Peripheral and central aggressive form of pindborg tumor of mandible-A rare case report. J Oral BiolCraniofac Res, 2013, 3(3), 154-158.
[19]	Singh N. Calcifying epithelia odontogenic tumor (Pindborg Tumor). Natl J MaxillofacSurg, 2011, 2(2), 225-227.
[20]	Franklin CD, Pindborg JJ. The calcifying epithelial odontogenic tumor: A review and analysis of 113 cases. Oral Surg Oral Med Oral Pathol,1976, 42, 753-65.
[21]	Cicconnetti A, Tallarico M, Bartoli A, Ripari A, Maggiani F. Calcifying epithelial odontogenic (Pindborg) Tumor. Minerva Stomatol, 2004, 53(6), 379-87.
[22]	Angadi PV, R. Calcifying epithelial Odontogenic tumor (Pindborg tumor). Head and Neck Pathology,2011,5(2), 137-9.
[23]	Kaushal S, Mathur SR, Vijay M, Rustagi A. Calcifying epithelial odontogenic tumor (Pindborg tumor) without calcification: A rare Entity. J Oral MaxillofacPathol, 2012, 16(1), 110-112.
[24]	Taneeru S, Guttikonda VR, Korlepara R, Gaddipati R, Kundoor K. Non Calcifying type of Calcifying epithelial odontogenic tumor: An unusual case report with special emphasis on histogenesis of calcification. J Oral MaxillofacSurg, 2017, 16(2), 253-257.
[25]	Afroz N, Jain A, Maheswari V, Ahmad SS. Non-calcifying variant of calcifying epithelial odontogenic tumor with clear cells-first case report of an extraosseous (peripheral) presentation. Eur J Gen Dent,2013, 2, 80-82.
[26]	Etit D, Uyaroglu MA, Erdogon N. Mixed odontogenic tumor: ameloblastoma and calcifying epithelial odontogenic tumor. Indian J PatholMicrob, 2010, 53 (1), 122-24.
[27]	More CB, Vijayvargiya R. Intraosseous calcifying epithelial odontogenic (Pindborg) tumor: A rare entity. J Oral MaxillofacPathol, 2015, 19(2), 269.
[28]	Ajila V, Gopakumar R, Hedge S, Shetty H. Calcifying epithelial odontogenic tumot of the posterior maxilla. Chrismed J Health Sci, 2016, 3 (1), 74-78.