International Journal of Dental Sciences and Research
ISSN (Print): 2333-1135 ISSN (Online): 2333-1259 Website: Editor-in-chief: Marcos Roberto Tovani Palone
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International Journal of Dental Sciences and Research. 2020, 8(1), 22-26
DOI: 10.12691/ijdsr-8-1-4
Open AccessArticle

Estimation of Salivary MMP-8, MMP-9, MMP-13 and TIMP-1 in Chronic Periodontitis in Mosul

Heba F. Hamodat1 and Mahmoud Y.M. Taha1,

1Department of Dental Basic Science, College Of Dentistry, Mosul University, Iraq

Pub. Date: January 19, 2020

Cite this paper:
Heba F. Hamodat and Mahmoud Y.M. Taha. Estimation of Salivary MMP-8, MMP-9, MMP-13 and TIMP-1 in Chronic Periodontitis in Mosul. International Journal of Dental Sciences and Research. 2020; 8(1):22-26. doi: 10.12691/ijdsr-8-1-4


The aim of the study was to estimate salivary concentrations of MMP-8, MMP-9, MMP-13, and TIMP-1in chronic periodontitis and control patients, and correlate periodontal parameters with salivary biomarkers in chronic periodontitis patients. The study group consisted of 44 patients suffering from chronic periodontitis, aging between ≤ 16-45 years old and 40 control samples collected from healthy individuals ranged between 16-40 years old. Chronic periodontitis was assessed on the basis of several periodontal parameters, including probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP) and plaque index (PI). 5ml of unstimulated saliva was collected from patients and control groups to measure salivary biomarkers by ELISA technique. All periodontal clinical parameters were significantly higher in chronic periodontitis patients compared to control group (p ≤ 0.000). Salivary MMP-8, MMP-9 and MMP-13 concentrations showed significant increase in chronic periodontitis (p ≤ 0.000), while salivary TIMP-1 level showed significant increase in control group comparing with periodontitis (p ≤ 0.000). Salivary MMP-13and MMP-9 showed significant difference in concentrations with different PPD, and CAL levels, while MMP-8 showed no significant difference, whereas all salivary biomarkers showed no significant difference with BOP index. According to Plaque index, MMP-8 concentration showed highly significant difference with different PI values.

Chronic periodontitis MMPs TIMP-1 periodontal parameters

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