International Journal of Clinical and Experimental Neurology
ISSN (Print): 2379-7789 ISSN (Online): 2379-7797 Website: Editor-in-chief: Zhiyou Cai, MD
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International Journal of Clinical and Experimental Neurology. 2014, 2(1), 4-7
DOI: 10.12691/ijcen-2-1-2
Open AccessOpinion Paper

Alcohol Abuse and Seizures: an Overview of Clinical Notions and Pathogenetic Theories

Gjon Preçi1 and Gentian Vyshka2,

1Doctoral School, Faculty of Medical and Technical Sciences, University of Medicine in Tirana, Albania

2Biomedical and Experimental Department, Faculty of Medicine, University of Medicine in Tirana, Albania

Pub. Date: September 08, 2014

Cite this paper:
Gjon Preçi and Gentian Vyshka. Alcohol Abuse and Seizures: an Overview of Clinical Notions and Pathogenetic Theories. International Journal of Clinical and Experimental Neurology. 2014; 2(1):4-7. doi: 10.12691/ijcen-2-1-2


Alcohol abuse is a major causative factor of different neurological disorders, among which seizures and epilepsy have an important burden of disease. Through discussing different pathogenetic mechanisms, scholars have tried to define and describe the diversity of clinical pictures and occurrences that might elicit a convulsive disorder in the alcoholics. An overview of the history of the diagnostic and classificatory attempts is made in the present paper, and distinctions between acute intoxication and withdrawal syndromes are summarized. The influences of ethanol on the cellular level and on the synaptic processes are succinctly mentioned. The authors are focused predominantly in three particularities of the alcohol-related seizures, namely the so-called alcoholic epilepsy, withdrawal seizures, and subacute encephalopathy with seizures in chronic alcoholism (SESA syndrome). Several sources are quoted, and the paper contains a brief overview on the efficacy of benzodiazepines and other antiepileptic drugs in the treatment of this variety of clinical events.

ethanol seizures epilepsy withdrawal syndrome chronic alcoholism

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