International Journal of Clinical and Diagnostic Research
ISSN (Print): 2395-3403 ISSN (Online): 2395-3403 Website: http://www.sciepub.com/journal/ijcdr Editor-in-chief: Apply for this position
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International Journal of Clinical and Diagnostic Research. 2013, 1(1), 31-39
DOI: 10.12691/ijcdr-1-1-4
Open AccessArticle

THYROID DYSFUNCTION IN TYPE 2 DIABETES MELLITUS

Wilma Delphine Silvia CR1, , Gandham Rajeev1 and Venkata Bharat Kumar Pinnelli2

1Department of Biochemistry, Akash Institute of Medical Sciences & Research Centre, Devanahalli, Bangalore Rural.

2Department of Biochemistry, Vydehi Institute of Medical Sciences & Research Centre, Bangalore.

Pub. Date: December 06, 2013

Cite this paper:
Wilma Delphine Silvia CR, Gandham Rajeev and Venkata Bharat Kumar Pinnelli. THYROID DYSFUNCTION IN TYPE 2 DIABETES MELLITUS. International Journal of Clinical and Diagnostic Research. 2013; 1(1):31-39. doi: 10.12691/ijcdr-1-1-4

Abstract

Diabetes Mellitus and thyroid disorders are two main endocrine disorders interrelated to each other and encountered in clinical practice. Diabetes patients have a higher prevalence of thyroid disorders than the normal population. Thyroid disease is found in both types 1 and 2 diabetes. A variety of thyroid abnormalities may co-exist and interact with diabetes mellitus. Diabetes mellitus appears to influence thyroid function in atleast two sites, one at the level of hypothalamic control of thyroid stimulating hormone (TSH) release and the other at the conversion of thyroxine (T4) to 3,5,3'-triiodothyronine (T3) in the peripheral tissue. Alterations in thyroid hormones indicate the characteristics of low T3 syndrome. Marked hyperglycemia decreases the activity and concentration of hepatic T4 -5' deiodinase. The relationship between diabetes mellitus and thyroid disorders is characterized by a complex interdependent interaction. Furthermore, it seems that unidentified thyroid dysfunction could negatively impact diabetes and its complications. Therefore, management of thyroid dysfunction in patients with diabetes may prove beneficial.

Keywords:
Diabetes Mellitus Thyroid Dysfunction Hypothyroidism Hyperthyroidism

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