International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2018, 6(3), 89-92
DOI: 10.12691/ijcd-6-3-1
Open AccessArticle

Isotretinoin-associated Celiac Disease

Hugh James Freeman1, and Michael Nimmo1

1Departments of Medicine (Gastroenterology) and Pathology, University of British Columbia, Vancouver, BC, Canada

Pub. Date: January 04, 2019

Cite this paper:
Hugh James Freeman and Michael Nimmo. Isotretinoin-associated Celiac Disease. International Journal of Celiac Disease. 2018; 6(3):89-92. doi: 10.12691/ijcd-6-3-1


27-yr old female marathon runner presented with profound fatigue and reduced exercise tolerance due to an iron deficiency anemia subsequent to treatment with isoretinoin for acne. Subsequent histologic and serologic studies revealed small bowel biopsies with histopathological features of celiac disease and an increased IgA tissue transglutaminase level. Isoretinoin use was terminated and after treatment with a gluten-free diet and oral iron, her symptoms resolved with normalization of her serological studies. Now, she remains completely well on a gluten-free diet alone and recently completed a full marathon.

Isoretinoin retinoic acid celiac disease intestinal inflammation colitis

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[1]  Freeman HJ Celiac disease. In: Reference Module in Biomedical Sciences. Elsevier. 6-Dec-2017.
[2]  Freeman HJ. Iron deficiency anemia in celiac disease. World J Gastroenterol 2015; 21: 9233-9238.
[3]  Freeman HJ. Drug-induced sprue-like intestinal disease. Int J Celiac Dis 2014; 2: 49-53.
[4]  Freeman HJ. Olmesartan enteropathy. Int J Celiac Dis 2016; 4: 24-26.
[5]  Spada C, Riccioni ME, Marchese M, Familiari P, Costamagna G. Isotretinoin-associated pan-enteritis. J Clin Gastroenterol 2008; 42: 923-925.
[6]  Lebwohl B, Sundstrom A, Jabri B, Kupfer SS, Green PH, Ludvigsson JF. Isotretinoin use and celiac disease: a population-based cross-sectional study. Am J Clin Dermatol 2014; 15: 537-542.
[7]  Rashtak S, Khaleghi S, Marietta EV, Pittelkow MR, Larson JJ, Lahr BD, Murray JA. Isotretinoin exposure and risk of celiac disease. PLoS One 2015; 10: 30135881.
[8]  Crockett SD, Porter CQ, Martin CF, Sandler RS, Kappelman MD. Isoretinoin use and the risk of inflammatory bowel disease: a case-control study. Am J Gastroenterol 2010; 105: 1986-1993.
[9]  Racine A, Cuerq A, Bijon A, Ricordeau P, Weill A, Allemand H, Chosidow O, Boutron-Ruault MC, Carbonnel F. Isoretinoin and risk of inflammatory bowel disease: a French nationwide study. Am J Gastroenterol 2014; 109: 563-569.