International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: http://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2018, 6(3), 89-92
DOI: 10.12691/ijcd-6-3-1
Open AccessArticle

Isotretinoin-associated Celiac Disease

Hugh James Freeman1, and Michael Nimmo1

1Departments of Medicine (Gastroenterology) and Pathology, University of British Columbia, Vancouver, BC, Canada

Pub. Date: January 04, 2019

Cite this paper:
Hugh James Freeman and Michael Nimmo. Isotretinoin-associated Celiac Disease. International Journal of Celiac Disease. 2018; 6(3):89-92. doi: 10.12691/ijcd-6-3-1

Abstract

27-yr old female marathon runner presented with profound fatigue and reduced exercise tolerance due to an iron deficiency anemia subsequent to treatment with isoretinoin for acne. Subsequent histologic and serologic studies revealed small bowel biopsies with histopathological features of celiac disease and an increased IgA tissue transglutaminase level. Isoretinoin use was terminated and after treatment with a gluten-free diet and oral iron, her symptoms resolved with normalization of her serological studies. Now, she remains completely well on a gluten-free diet alone and recently completed a full marathon.

Keywords:
Isoretinoin retinoic acid celiac disease intestinal inflammation colitis

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