International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
Open Access
Journal Browser
International Journal of Celiac Disease. 2018, 6(3), 74-75
DOI: 10.12691/ijcd-6-3-3
Open AccessArticle

Hypercoagulability State in Celiac Disease and Hepatitis C Association

Cornel Aldea1, 2, Daniel Sur1 and Ciprian Silaghi1,

1Emergency Clinical Hospital for Children, Cluj-Napoca, Romania

2Iuliu Hatieganu, University of Medicine and Pharmacy, Cluj-Napoca, Romania

Pub. Date: January 04, 2019

Cite this paper:
Cornel Aldea, Daniel Sur and Ciprian Silaghi. Hypercoagulability State in Celiac Disease and Hepatitis C Association. International Journal of Celiac Disease. 2018; 6(3):74-75. doi: 10.12691/ijcd-6-3-3


A concerning pathological and serological aspect that is found in both HCV and celiac disease is the hypercoagulability state which can lead to various complications.

celiac disease hepatitis C hypercoagulability state

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Samaşca G, Burac L, Farcău D, Dejica D. Celiac disease screening in viral hepatitis C. Romanian Journal of Pediatrics 2010; 59(1): 49-50.
[2]  Sur ML, Colceriu M, Aldea C, Sur G, Floca E. Celiac Disease a Road Paved with Many Obstacles. Differential Diagnosis in Children. International Journal of Celiac Disease 2018; 6(1): 7-10.
[3]  Lerner A, Blank M. Hypercoagulability in celiac disease - an update. Autoimmun Rev. 2014; 13(11): 1138-41.
[4]  Lacombe J, Ferron M. Gamma-carboxylation regulates osteocalcin function. Oncotarget. 2015; 6(24): 19924-5.
[5]  Bellido-Martin L, de Frutos PG. Vitamin K-dependent actions of Gas6. Vitam Horm 2008; 78: 185-209.
[6]  Silaghi CN, Fodor D, Crăciun AM. Circulating matrix Gla protein: a potential tool to identify minor carotid stenosis with calcification in a risk population. Clin Chem Lab Med 2013; 51: 1115-1123.
[7]  Silaghi CN, Gheorghe SR, Fodor D, Crăciun AM. Circulating matrix Gla protein in patients with vascular pathology. Human and Veterinary Medicine 2016; 8: 187-191.
[8]  Janeczko CE, Sweeney K, Connaghan G. Supplemental vitamin K improves the stability of anticoagulation in a patient with low tissue stores of vitamin K secondary to coeliac disease. BMJ Case Rep. 2009; 2009. pii: bcr10.2008.1067.
[9]  Berthoux E, Fabien N, Chayvialle JA, Ninet J, Durieu I. Adult celiac disease with thrombosis: a case series of seven patients. Role of thrombophilic factors. Rev Med Interne. 2011; 32: 600-4.
[10]  Senzolo M, Burra P, Cholongitas E, Burroughs AK. New insights into the coagulopathy of liver disease and liver transplantation. World J Gastroenterol. 2006; 12(48): 7725-36.
[11]  Tripodi A, Mannucci PM. Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. J Hepatol. 2007; 46(4): 727-33.
[12]  Al Ghumlas AK, Abdel Gader AG, Al Faleh FZ. Haemostatic abnormalities in liver disease: could some haemostatic tests be useful as liver function tests? Blood Coagul Fibrinolysis. 2005; 16(5): 329-35.
[13]  Saray A, Mesihovic R, Vanis N, Gornjakovic S, Prohic D. Clinical significance of haemostatic tests in chronic liver disease. Med Arch. 2012; 66(4): 231-5.
[14]  Gonzalez-Reimers E, Quintero-Platt G, Martin-Gonzalez C, Perez-Hernandez O, Romero-Acevedo L, Santolaria-Fernandez F. Thrombin activation and liver inflammation in advanced hepatitis C virus infection. World J Gastroenterol. 2016; 22(18): 4427-37.
[15]  Poujol-Robert A, Boëlle PY, Poupon R, Robert A. Factor V Leiden as a risk factor for cirrhosis in chronic hepatitis C. Hepatology. 2004; 39(4): 1174-5.
[16]  Poujol-Robert A, Rosmorduc O, Serfaty L, Coulet F, Poupon R, Robert A. Genetic and acquired thrombotic factors in chronic hepatitis C. Am J Gastroenterol. 2004; 99(3): 527-31.
[17]  Wang C-C, Chang C-T, Lin C-L, Lin I-C, Kao C-H. Hepatitis C Virus Infection Associated With an Increased Risk of Deep Vein Thrombosis: A Population-Based Cohort Study. Medicine (Baltimore). 2015; 94(38): e1585.
[18]  Liebman HA, Furie BC, Tong MJ, Blanchard RA, Lo KJ, Lee SD, et al. Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med. 1984; 310(22): 1427-31.
[19]  Kamel MM, Saad MF, Mahmoud AA, Edries AA, Abdel-Moneim AS. Evaluation of serum PIVKA-II and MIF as diagnostic markers for HCV/HBV induced hepatocellular carcinoma. Microb Pathog. 2014; 77: 31-5.
[20]  Anstee QM, Dhar A, Thursz MR. The role of hypercoagulability in liver fibrogenesis. Clin Res Hepatol Gastroenterol. 2011; 35(8-9): 526-33.