International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2018, 6(3), 64-67
DOI: 10.12691/ijcd-6-3-4
Open AccessArticle

Optimization of Diagnosis and Treatment of Lactose Intolerance in Infants

Noila K. Tolipova1, Sevara B. Azimova2 and Dilorom R. Ataeva1,

1Department of Children’s disease №2, Tashkent Medical Academy, Tashkent, Uzbekistan

2Department of Normal and Pathologic Physiology, Tashkent Medical Academy, Tashkent, Uzbekistan

Pub. Date: January 04, 2019

Cite this paper:
Noila K. Tolipova, Sevara B. Azimova and Dilorom R. Ataeva. Optimization of Diagnosis and Treatment of Lactose Intolerance in Infants. International Journal of Celiac Disease. 2018; 6(3):64-67. doi: 10.12691/ijcd-6-3-4


The paper presents the results of a study of the Benedict test for deciding the diagnosis of lactose intolerance in children and the effectiveness of lactase drugs. Benedict test is one of the standard methods for the diagnosis of lactose intolerance in children. Drugs with lactase enzyme that helps break down lactose (hydrolysis) into two simple sugars, glucose and galactose, which simplifies digestion. Lactase drugs has been shown to be the best way to preserve natural feeding in children with lactose intolerance, since the lactase composition is involved in the breakdown and absorption of carbohydrates and proteins, produce essential vitamins for improving the health and immunity of the child, normalize the composition of the intestinal flora.

lactose lactase lactose intolerance lactose resistance lactase deficiency Benedict test diarrhea flatulence

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[1]  Brand Miller J, McVeagh P. Human milk oligosaccharides: 130 reasons to breast-feed. Br J Nutr. 1999; 82: 333-5.
[2]  Berni Canani R, Passariello A, Buccigrossi V, Terrin G, Guarino A. The nutritional modulation of the evolving intestine. J Clin Gastroenterol. 2008; 42(Suppl 3): S197-200.
[3]  Cox, M.; Nelson, D. Lehninger Principles of Biochemistry 3rd ed. Worth Publishers, 2000.
[4]  “Living with lactose intolerance: If you take some simple steps, you can continue to enjoy a variety of dietary favorites” Ebony Oct. 2002 v57 i12 p66.
[5]  Mattar, R., D.F. de Campos Mazo, and F.J. Carrilho, Lactose intolerance: diagnosis,
[6]  genetic, and clinical factors. Clin Exp Gastroenterol, 2012. 5: p. 113-21.
[7]  Krasinski, S.; Lee, M. “Human Adult-Onset Lactase Decline: An Update” Nutrition Reviews v.56 (1) Jan. 1988.
[8]  MacGillivray S, Fahey T, McGuire W. Lactose avoidance for young children with acute diarrhoea. Cochrane Database Syst Rev. 2013; 10: CD005433.
[9]  Stepahno Guandalini, Anil Dhawan, David Branski. Textbook of Pediatric Gastroenterology, Hepatology and Nutrition. A Comprehensive Guide to practice. 2016: 2015939902.
[10]  de Mattos AP, Ribeiro TC, Mendes PS, Valois SS, Mendes CM, Ribeiro HC Jr. Comparison of yogurt, soybean, casein, and amino acid-based diets in children with persistent diarrhea. Nutr Res. 2009; 29: 462-9.
[11]  Olafsdottir E, Aksnes L, Fluge G, Berstad A. Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and healthy children. Acta Paediatr. 2002; 91: 45-50.
[12]  de Vrese M, Stegelmann A, Richter B, Fenselau S, Laue C, Schrezenmeir J. Probiotics—compensation for lactase insufficiency. Am J Clin Nutr. 2001; 73(2 Suppl): 421S-9S.
[13]  Studenikin B.M., Tursunxujayeva S.Sh.,Lactase intolerance. № 1. — С. 28-30.
[14]  USMLE, Kaplan/ Biochemistry and Medical Genetics/ Step 1, Lecture Notes 2018. Chapter 12, p190-198.
[15]  Jose M Moreno-Villares, Isabel Polanco. Paediatric gastroenterology. An atlas of investigation and management. Clinical publishing. Oxford. Atlas Medical Publishing Ltd 2009. p50-58.