Screening for Celiac Disease in Rheumatology: HLA First?

Hakim Rahmoune^1, , Nada Boutrid¹, Mounira Amrane² and Belkacem Bioud¹

¹Pediatrics Department, Setif University Hospital; Setif-1 University, Algeria

²Biochemistry Department, Setif University Hospital; Setif-1 University, Algeria

Cite this paper:
Hakim Rahmoune, Nada Boutrid, Mounira Amrane and Belkacem Bioud. Screening for Celiac Disease in Rheumatology: HLA First?. International Journal of Celiac Disease. 2017; 5(1):30-32. doi: 10.12691/ijcd-5-1-2

Abstract

HLA genes have been shown to be strongly associated with a large repertoir of autoimmune diseases including Rheumatoid Arthritis (RA), Juvenile idiopathic arthritis (JIA) and Celiac Disease (CD). The present article will discuss what is the place of performing celiac disease associated serology in face of a rheumatologic patient, when gluten enteropaty is suspected. More specifically, should HLA be done prior to the serology? Unnecessary serial serological CD screening in such rheumatology patients could be avoided by performing an HLA typing, as a long-life marker of genetically CD-susceptible patients.

Keywords:
celiac disease rheumatoid arthritis juvenile rheumatoid arthritis rheumatology HLA

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References:

[1]	Lerner A, Jeremias P, Matthias T. The World Incidence and Prevalence of Autoimmune Diseases is Increasing. International Journal of Celiac Disease. 2015 Nov 16; 3(4): 151-5.
[2]	Barakauskas VE, Lam GY, Estey MP. Digesting all the options: Laboratory testing for celiac disease. Critical reviews in clinical laboratory sciences. 2014 Dec 1; 51(6): 358-78.
[3]	Howell WM. HLA and disease: guilt by association. International journal of immunogenetics. 2014 Feb 1; 41(1): 1-2.
[4]	Hersh AO, Prahalad S. Immunogenetics of juvenile idiopathic arthritis: A comprehensive review. Journal of autoimmunity. 2015 Nov 30; 64: 113-24.
[5]	Koning F. Recent insight in the pathophysiology of coeliac disease: relevance to rheumatoid arthritis. Clin Exp Rheumatol. 2015 Jul 1; 33(4 Suppl 92): 8-10.
[6]	Koning F, Thomas R, Rossjohn J, Toes RE. Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens. Nature Reviews Rheumatology. 2015 Aug 1; 11(8): 450-61.
[7]	Rossi-Semerano L, Koné-Paut I. Is Still's disease an autoinflammatory syndrome? International journal of inflammation. 2012 Apr 26; 2012.
[8]	Fasano ME, Dametto E, D’Alfonso S. HLA Genotyping: Methods for the Identification of the HLA-DQ2,-DQ8 Heterodimers Implicated in Celiac Disease (CD) Susceptibility. Celiac Disease: Methods and Protocols. 2015: 79-92.
[9]	Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. Journal of pediatric gastroenterology and nutrition. 2012 Jan 1; 54(1): 136-60.
[10]	Anderson RP, Henry MJ, Taylor R, Duncan EL, Danoy P, Costa MJ, Addison K, Tye-Din JA, Kotowicz MA, Knight RE, Pollock W. A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways. BMC medicine. 2013 Aug 28; 11(1): 1.
[11]	Lund F, Hermansen MN, Pedersen MF, Hillig T, Toft–Hansen H, Sölétormos G. Mapping of HLA–DQ haplotypes in a group of Danish patients with celiac disease. Scandinavian journal of clinical and laboratory investigation. 2015 Aug 18; 75(6): 519-22.
[12]	Aguayo-Patrón S, Beltrán-Sauceda L, Calderón de la Barca AM. A population-wide applicable HLA-DQ2 and DQ8 genotyping using DNA from dried blood spots and duplex allele-specific qPCR amplification. Scandinavian Journal of Clinical and Laboratory Investigation. 2016 Oct 2; 76(7): 581-7.
[13]	Mitchell RT, Sun A, Mayo A, et al. Coeliac screening in a Scottish cohort of children with type 1 diabetes mellitus: is DQ typing the way forward? Arch Dis Child 2016; 101: 230-3.
[14]	Rashid M, Lee J. Serologic testing in celiac disease Practical guide for clinicians. Canadian Family Physician. 2016 Jan 1; 62(1): 38-43.
[15]	Samaşca G, Sur G, Lupan I. Current trends and investigative developments in celiac disease. Immunological investigations. 2013 May 1; 42(4): 273-84.
[16]	Snyder J, Butzner JD, DeFelice AR, et al. Evidence-Informed Expert Recommendations for the Management of Celiac Disease in Children. Pediatrics 2016; 138.
[17]	Ludvigsson JF, Card TR, Kaukinen K, Bai J, Zingone F, Sanders DS, Murray JA. Screening for celiac disease in the general population and in high-risk groups. United European gastroenterology journal. 2015 Apr 1; 3(2): 106-20.
[18]	Crovella S, Brandao L, Guimaraes R, de Lima Filho JL, Arraes LC, Ventura A, Not T. Speeding up coeliac disease diagnosis in the developing countries. Digestive and Liver Disease. 2007 Oct 31; 39(10): 900-2.
[19]	Barada K, Daya HA, Rostami K, Catassi C. Celiac disease in the developing world. Gastrointestinal endoscopy clinics of North America. 2012 Oct 31; 22(4): 773-96.