International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: http://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2016, 4(4), 135-137
DOI: 10.12691/ijcd-4-4-9
Open AccessArticle

Too Few Studies Provided a Link between Viral Infections and Celiac Disease

Iulian Diaconescu1, , Giulia Alexandru1, Rahela Carpa1, Iulia Lupan2, Corina Crisan3, Lucia Sur4, Genel Sur5 and Anamaria Girbovan6

1Department of Microbiology, Babes Bolyai University, Cluj-Napoca, Romania

2Department of Molecular Biology, Babes Bolyai University, Cluj-Napoca, Romania

3Emergency Hospital for Children, Cluj-Napoca, Romania

4Department of Pediatrics I, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

5Department of Pediatrics II, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

6Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

Pub. Date: December 03, 2016

Cite this paper:
Iulian Diaconescu, Giulia Alexandru, Rahela Carpa, Iulia Lupan, Corina Crisan, Lucia Sur, Genel Sur and Anamaria Girbovan. Too Few Studies Provided a Link between Viral Infections and Celiac Disease. International Journal of Celiac Disease. 2016; 4(4):135-137. doi: 10.12691/ijcd-4-4-9

Abstract

Introduction. Celiac disease has a prevalence of 1% of the global population and it is increasing every year. Viral infections such as hepatitis C and hepatitis B are the most common liver diseases and studies show that may be a link between them and celiac disease. Recent studies show attempts to find a link between viral infections and celiac disease. We focused our study on the association between viral infections and celiac disease. Material and Method. We studied 63 articles from the Pub Med Database that revealed a possible connection between viral infections and celiac disease. Results. Since it is more frequent, hepatitis C is associated with the development of celiac disease, but celiac disease is not the autoimmune manifestation of hepatitis C. Patients with celiac disease have a significantly decreased response to hepatitis B vaccine. Other viruses that are associated with celiac disease are: rotavirus, adenovirus, eterovirus and Epstein-Barr virus. Conclusions. The serological screening for celiac disease at hepatitis C patients, after starting treatment with interferon, is necessary. Also, it is justified the serological screening for celiac disease among adults infected with hepatitis B. Further studies are still needed to show the possible association of viral infections in the pathogenesis of celiac disease.

Keywords:
celiac disease viral infection possible connection

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Sarmiento L, Galvan JA, Cabrera-Rode E, Aira L, Correa C, Sariego S, Fonseca M, Cubas-Dueñas I, Hung LH, Resik S, Cilio, CM. Type 1 diabetes associated and tissue transglutaminase autoantibodies in patients without type 1 diabetes and coeliac disease with confirmed viral infections. J Med Virol 2012; 84: 1049-1053.
 
[2]  Capriati T, Francavilla R, Castellaneta S, Ferretti F, Diamanti A. Impact of the birth's season on the development of celiac disease in Italy. Eur J Pediatr 2015; 174: 1657-1663.
 
[3]  Zhu H, Wu J, Shen X. Genome-wide association study: new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes. Scand J Gastroenterol 2016; 31: 1-7.
 
[4]  Lernmark Å. Environmental factors in the etiology of type 1 diabetes, celiac disease, and narcolepsy. Pediatr Diabetes 2016; 17: 65-72.
 
[5]  Samasca G, Sur G, Lupan I. Current trends and investigative developments in celiac disease. Immunol Invest 2013; 42: 273-284.
 
[6]  Fine KD, Ogunji F, Saloum Y, Beharry S, Crippin J, Weinstein J. Celiac sprue: another autoimmune syndrome associated with hepatitis C. Am J Gastroenterol 2001; 96: 138-145.
 
[7]  Vivas S, Ruiz de Morales JM, Martinez J, González MC, Martín S, Martín J, Cechini C, Olcoz JL. Human recombinant anti-transglutaminase antibody testing is useful in the diagnosis of silent coeliac disease in a selected group of at-risk patients. Eur J Gastroenterol Hepatol 2003; 15: 479-483.
 
[8]  Durante-Mangoni E, Iardino P, Resse M, Cesaro G, Sica A, Farzati B, Ruggiero G, Adinolfi LE. Silent celiac disease in chronic hepatitis C: impact of interferon treatment on the disease onset and clinical outcome. J Clin Gastroenterol 2004; 38: 901-905.
 
[9]  Thevenot T, Denis J, Jouannaud V, Monnet E, Renou C, Labadie H, Abdelli N, Nguyen-Khac E, Dumouchel P, Bresson-Hadni S, Chousterman M, DI Martino V, Cadranel JF. Coeliac disease in chronic hepatitis C: a French multicentre prospective study. Aliment Pharmacol Ther 2007; 26: 1209-1216.
 
[10]  Samaşca G, Burac L, Farcåu D, Dejica D. Celiac disease screening in chronic viral hepatitis C. Ro J Pediatr 2010; 9: 49-50.
 
[11]  Garg A, Reddy C, Duseja A, Chawla Y, Dhiman RK. Association between Celiac Disease and Chronic Hepatitis C Virus Infection. J Clin Exp Hepatol 2011; 1: 41-44.
 
[12]  Casella G, Viganò D, Romano Settanni C, Morelli O, Villanacci V, Baldini V, Bassotti G. Association between celiac disease and chronic hepatitis C. Gastroenterol Hepatol Bed Bench 2016; 9: 153-157.
 
[13]  Noh KW, Poland GA, Murray JA. Hepatitis B vaccine nonresponse and celiac disease. Am J Gastroenterol 2003; 98: 2289-2292.
 
[14]  Ertem D, Gonen I, Tanidir C, Ugras M, Yildiz A, Pehlivanoğlu E, Eksioglu-Demiralp E. The response to hepatitis B vaccine: does it differ in celiac disease? Eur J Gastroenterol Hepatol 2010; 22: 787-793.
 
[15]  Leonardi S, La Rosa M. Are hepatitis B virus and celiac disease linked? Hepat Mon 2010; 10: 173-175.
 
[16]  Vitaliti G, Praticò AD, Cimino C, Di Dio G, Lionetti E, La Rosa M, Leonardi S. Hepatitis B vaccine in celiac disease: yesterday, today and tomorrow. World J Gastroenterol 2013; 19: 838-845.
 
[17]  Heshin-Bekenstein M, Turner D, Shamir R, Bar-Meir M, Dagan R, Zevit N, Silbermintz A. Hepatitis B Virus Revaccination With Standard Versus Pre-S Vaccine in Previously Immunized Patients With Celiac Disease. J Pediatr Gastroenterol Nutr 2015; 61: 400-403.
 
[18]  Opri R, Veneri D, Mengoli C, Zanoni G. Immune response to Hepatitis B vaccine in patients with celiacdisease: A systematic review and meta-analysis. Hum Vaccin Immunother 2015; 11: 2800-2805.
 
[19]  Nau AL, Fayad L, Lazzarotto C, Shiozawa MB, Dantas-Corrêa EB, Schiavon L de L, Narciso-Schiavon JL. Prevalence and clinical features of celiac disease in patients with hepatitis B virus infection in Southern Brazil. Rev Soc Bras Med Trop 2013; 46: 397-402.
 
[20]  Narciso-Schiavon JL, Schiavon LL. Is screening for Celiac Disease Needed in Patients with Liver Disease? International Journal of Celiac Disease 2015; 3: 91-94.
 
[21]  Stene LC, Honeyman MC, Hoffenberg EJ, Haas JE, Sokol RJ, Emery L, Taki I, Norris JM, Erlich HA, Eisenbarth GS, Rewers M. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 2006; 101: 2333-2340.
 
[22]  Dolcino M, Zanoni G, Bason C, Tinazzi E, Boccola E, Valletta E, Contreas G, Lunardi C, Puccetti A. A subset of anti-rotavirus antibodies directed against the viral protein VP7 predicts the onset of celiac disease and induces typical features of the disease in the intestinal epithelial cell line T84. Immunol Res 2013; 56: 465-476.
 
[23]  Ziberna F, De Lorenzo G, Schiavon V, Arnoldi F, Quaglia S, De Leo L, Vatta S, Martelossi S, Burrone OR, Ventura A, Not T. Lack of evidence of rotavirus-dependent molecular mimicry as a trigger of coeliac disease. Clin Exp Immunol 2016.
 
[24]  Samaşca G, Pîrvan A, Miu N, Andreica M, Cristea V, Dejica D. Adenoviruses in celiac disease in children. Ro J Infect Dis 2014; 14: 5-9.
 
[25]  Carlsson AK, Lindberg BA, Bredberg AC, Hyöty H, Ivarsson SA. Enterovirus infection during pregnancy is not a risk factor for celiac disease in the offspring. J Pediatr Gastroenterol Nutr 2002; 35: 649-652.
 
[26]  Tjernberg AR, Ludvigsson JF. Children with celiac disease are more likely to have attended hospital for prior respiratory syncytial virus infection. Dig Dis Sci 2014; 59: 1502-1508.
 
[27]  Perfetti V, Baldanti F, Lenti MV, Vanoli A, Biagi F, Gatti M, Riboni R, Dallera E, Paulli M, Pedrazzoli P, Corazza GR. Detection of Active Epstein-Barr Virus Infection in Duodenal Mucosa of Patients With Refractory Celiac Disease. Clin Gastroenterol Hepatol 2016; 14: 1216-1220.