International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2016, 4(4), 127-129
DOI: 10.12691/ijcd-4-4-1
Open AccessEditorial

Beyond the Joint: What’s Happening in the Gut

Aaron Lerner1, 2, , Sandra Neidhöfer2 and Torsten Matthias2

1B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

2AESKU.KIPP Institute, Wendelsheim, Germany

Pub. Date: December 03, 2016

Cite this paper:
Aaron Lerner, Sandra Neidhöfer and Torsten Matthias. Beyond the Joint: What’s Happening in the Gut. International Journal of Celiac Disease. 2016; 4(4):127-129. doi: 10.12691/ijcd-4-4-1


Rheumatoid arthritis and celiac disease belong to the autoimmune disease family. Despite being separate entities they share multiple serological and genetic aspects. Celiac disease associated serum bio-markers are observed in rheumatoid arthritis. Contrary to their specific HLA pre-disposition, the diseases share multiple non-HLA loci. Those genes are crucial for activation and regulation of adaptive and innate immunity. Recently, light was shed on the interaction between host genetics and microbiota composition in relation to celiac disease and rheumatoid arthritis susceptibility, connecting bugs and us and autoimmunity. The present editorial updates and clarifies those aspects.

celiac disease rheumatoid arthritis serology genetics gut-joint axis bio-marker

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