International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2016, 4(3), 92-94
DOI: 10.12691/ijcd-4-3-12
Open AccessArticle

Nutrients, Bugs and Us: The Short-chain Fatty Acids Story in Celiac Disease

Aaron Lerner1, 2, , Jeremias Patricia2 and Torsten Matthias2

1B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

2AESKU.KIPP Institute, Wendelsheim, Germany

Pub. Date: October 11, 2016

Cite this paper:
Aaron Lerner, Jeremias Patricia and Torsten Matthias. Nutrients, Bugs and Us: The Short-chain Fatty Acids Story in Celiac Disease. International Journal of Celiac Disease. 2016; 4(3):92-94. doi: 10.12691/ijcd-4-3-12


The gut ecosystem with myriads of microorganisms and the high concentration of immune system cells can be considered as a separate organ on its own. The balanced interaction between the host and microbial cells has been shaped during the long co-evolutionary process. In dysbiotic conditions, however, this balance is compromised and results in abnormal interaction between the host and microbiota. Celiac disease is such an example were dysbiotic and metabolic signature are shaping the disease progression in genetically susceptible individuals. Short chain fatty acids are bacterial originated metabolic messenger between the pathobionts and the intestinal mucosa. Their local luminal effects and systemic ones were just recently unraveled. Accumulating data attribute multiple beneficial effects to them. Changes in microbiota and their short-chain fatty acids production is clearly related to the pathogenesis of celiac disease and might open new therapeutic strategies to combat the disease.

celiac disease stool microbiota dysbiota bacteria short-chain fatty acids

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