International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: http://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2016, 4(2), 61-63
DOI: 10.12691/ijcd-4-2-10
Open AccessArticle

IgA Tissue Transglutaminase Antibodies at Different cut-offs in the Evaluation of Possible Celiac Patients

Gabriel Samasca1, Pirvan Alexandru2, Genel Sur2, Abrudan Carmen3, Iulia Lupan4, and Diana Deleanu1

1Department of Immunology and Allergology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

2Department of Pediatrics II, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

3Emergency Hospital for Children, Cluj-Napoca, Romania

4Institute for Interdisciplinary Research in Bio-Nano-Science, “Babes-Bolyai” University, Cluj-Napoca, Romania

Pub. Date: May 28, 2016

Cite this paper:
Gabriel Samasca, Pirvan Alexandru, Genel Sur, Abrudan Carmen, Iulia Lupan and Diana Deleanu. IgA Tissue Transglutaminase Antibodies at Different cut-offs in the Evaluation of Possible Celiac Patients. International Journal of Celiac Disease. 2016; 4(2):61-63. doi: 10.12691/ijcd-4-2-10

Abstract

The celiac disease screening with IgA tissue transglutaminase antibodies depends on the cut-off reaction, therefore many patients with values less but close to the cut-off may be undiagnosed. Material and Method. We conducted the CD screening with IgA tissue transglutaminase antibodies in a group of 1616 children during 2014 at a cut-off of 25 U/ml and at a cut-off of 10 U/ml. We also wanted to compare our results with IgA tissue transglutaminase antibodies prevalence from other countries. Results. We found a IgA tissue transglutaminase antibodies prevalence rate of 3% for values higher 25 U/ml and a IgA tissue transglutaminase antibodies prevalence rate of 1.6% for values between 10-25 U/ml. A prevalence of 13.6% for IgA tissue transglutaminase antibodies was observed in , and . Conclusions. We observed a 4.6% IgA tissue transglutaminase antibodies prevalence at a cut-off of 10 U/ml. Prevalence of IgA tissue transglutaminase antibodies from Romania is lowered compared with other European countries.

Keywords:
celiac disease screening cut-off

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References:

[1]  Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, et al. European Society for Pediatric Gastroen Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012;54:136-160.
 
[2]  Webb C, Norström F, Myléus A, Ivarsson A, Halvarsson B, Högberg L, et al. Celiac Disease Can be Predicted by High Levels of Anti-Tissue Transglutaminase Antibodies in Population-Based Screening. J Pediatr Gastroenterol Nutr. 2015:60:787-791.
 
[3]  Fasano A, Araya M, Bhatnagar S, Cameron D, Catassi C, Dirks M et al. Consensus guidelines. J Pediatr Gastroenterol Nutr 2008; 47:214-219.
 
[4]  Samasca G, Sur G, Lupan I. Current Trends and Investigative Developments in Celiac Disease. Immunological Investigation 2013; 42:273-284.
 
[5]  Hojsak I, Shamir R. Tissue transglutaminase antibodies in celiac disease: focus on the pediatric population. Drugs Today (Barc). 2011;47:683-691.
 
[6]  Gabriel S, Mihaela I, Angela B, Mariana A, Doru D. Prevalence of IgA antitissue transglutaminase antibodies in children with type 1 diabetes mellitus. J Clin Lab Anal. 2011;25:156-161.
 
[7]  Waisbourd-Zinman O, Hojsak I, Rosenbach Y, Mozer-Glassberg Y, Shalitin S, Phillip M, et al. Spontaneous normalization of anti-tissue transglutaminase antibody levels is common in children with type 1 diabetes mellitus. Dig Dis Sci. 2012;57:1314-1320.
 
[8]  Samaşca G, Iancu M, Farcău D, Butnariu A, Pop T, Pîrvan A, et al. IgA anti-tissue transglutaminase antibodies, first line in the diagnosis of celiac disease. Clin Lab. 2011;57:695-701.
 
[9]  Makovicky P, Rimarova K, Boor A, Makovicky P, Vodicka P, Samasca G, et al. Correlation between antibodies and histology in celiac disease: incidence of celiac disease is higher than expected in the pediatric population. Mol Med Rep. 2013;8:1079-1083.
 
[10]  Husby S, Murray JA. Diagnosing coeliac disease and the potential for serological markers. Nat Rev Gastroenterol Hepatol. 2014;11:655-663.
 
[11]  Health Quality Ontario. Clinical utility of serologic testing for celiac disease in ontario: an evidence-based analysis. Ont Health Technol Assess Ser. 2010;10:1-111.
 
[12]  Lerner A, Jeremias P, Matthias M. Outside of Normal Limits: False Positive/Negative Anti TG2 Autoantibodies. International Journal of Celiac Disease. 2015:3:87-90.
 
[13]  Dalgic B1, Sari S, Basturk B, Ensari A, Egritas O, Bukulmez A, et al. Prevalence of celiac disease in healthy Turkish school children. Am J Gastroenterol. 2011;106:1512-1517.
 
[14]  Farahmand F, Modaresi V, Najafi M, Khodadad A, Moetamed F, Modarres Z. Prevalence of celiac disease in Iranian children with recurrent abdominal pain referred to a pediatric referral center. Iran J Pediatr. 2011;21:33-38.
 
[15]  Mora M, Litwin N, Toca Mdel C, Azcona MI, Solís Neffa R, Battiston F, et al. Prevalence of celiac disease: multicentric trial among pediatric population from five urban districts in Argentina. Arch Argent Pediatr. 2012;110:490-496.
 
[16]  Alessandrini S, Giacomoni E, Muccioli F. Mass population screening for celiac disease in children: the experience in Republic of San Marino from 1993 to 2009. Ital J Pediatr. 2013;39:67.
 
[17]  Chogle A, Saps M. Yield and cost of performing screening tests for constipation in children. Can J Gastroenterol. 2013;27:e35-38.
 
[18]  Fortunato F, Martinelli D, Cozza V, Ciavarella P, Valente A, Cazzato T, et al. Italian family paediatricians' approach and management of celiac disease: a cross-sectional study in Puglia Region, 2012. BMC Gastroenterol. 2014;14:38.
 
[19]  Jansen MA, Tromp II, Kiefte-de Jong JC, Jaddoe VW, Hofman A, Escher JC, et al. Infant feeding and anti-tissue transglutaminase antibody concentrations in the Generation R Study. Am J Clin Nutr. 2014;100:1095-1101.
 
[20]  Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, Jörneus O, et al. Clinical features of celiac disease: a prospective birth cohort. Pediatrics. 2015;135:627-634.