International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2016, 4(2), 38-39
DOI: 10.12691/ijcd-4-2-7
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Is Enzyme Supplementation Effective Strategy to Reduce the Burden of Gluten Free Diet in Celiac Disease?

Aaron Lerner1,

1B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Pub. Date: May 28, 2016

Cite this paper:
Aaron Lerner. Is Enzyme Supplementation Effective Strategy to Reduce the Burden of Gluten Free Diet in Celiac Disease?. International Journal of Celiac Disease. 2016; 4(2):38-39. doi: 10.12691/ijcd-4-2-7


Several strategies have been considered for enzymatic detoxification of dietary gluten and to reduce immunogenisity of gliadin peptides. An enzymatic therapy using enterically coated tablets containing caricain (Gluteguard), originated from a papaya, on celiac disease patients challenged with gluten was reported. Glut guard was able to protect these patients from adverse symptoms being induced by gluten challenge. The advantages of the fruit originated preparation are: it does not contain living microbes or bacterial purified or engineered products. It can be considered as a preventive therapy and further step in the future therapeutical strategy race for the celiac affected population benefits.

celiac disease enzyme supplementation gluten gluten free diet microbial transglutaminase therapy

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