International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: http://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2016, 4(1), 30-33
DOI: 10.12691/ijcd-4-1-8
Open AccessCase Report

The Association of Crohn’s Disease, Celiac Disease and Selective Ig A Deficiency

Ludmila Tankova1, Vanya Gerova1, Plamen Getsov2, Nikolay Penkov3, Gergana Taneva1, Ivan Terziev4 and Radislav Nakov1,

1Clinic of Gastroenterology, Clinical Center of Gastroenterology, University Hospital “Queen Joanna”, Sofia, Bulgaria

2Department of Radiology, University Hospital “Queen Joanna”, Sofia, Bulgaria

3Clinic of Abdominal Surgery, Clinical Center of Gastroenterology, University Hospital “Queen Joanna”, Sofia, Bulgaria

4Department of Pathology, University Hospital “Queen Joanna”, Sofia, Bulgaria

Pub. Date: February 16, 2016

Cite this paper:
Ludmila Tankova, Vanya Gerova, Plamen Getsov, Nikolay Penkov, Gergana Taneva, Ivan Terziev and Radislav Nakov. The Association of Crohn’s Disease, Celiac Disease and Selective Ig A Deficiency. International Journal of Celiac Disease. 2016; 4(1):30-33. doi: 10.12691/ijcd-4-1-8

Abstract

Concomitant occurrence of celiac disease (CeD) and Crohn’s disease (CD) is rare and has been reported in several case reports and series. We report a case of a 63-year-old man with proximal CD, CeD and selective immunoglobulin (Ig) A deficiency (SIgAD). The patient was admitted in our Clinic for evaluation of epigastric pain, nausea, vomiting and weight loss (up to 7 kg) appeared in the last 3 months. The imaging findings from abdominal ultrasound and CT enterography raised suspicion of a lymphoproliferative disease of the jejunum. To exclude the development of lymphoma based on long standing untreated atypical CeD, upper endoscopy with biopsies and serological tests were conducted, showing and subtotal villous atrophy and elevated levels of IgG tissue transglutaminase tTG. Histopathology documented CD (A3,L4,B2 according to Montreal’s classification).

Keywords:
silent celiac disease selective Ig A deficiency Crohn’s Disease

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