International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2016, 4(1), 9-10
DOI: 10.12691/ijcd-4-1-10
Open AccessEditorial

Is HLA Typing a Diagnostic Tool in Celiac Disease?

Andreea L. Rachisan1, , Alexandru Pirvan1, Nicolae Miu1, Dan Gheban2, Adrian Hrusca3, Gabriel Samasca4 and Iulia Lupan5

1Department of Pediatrics II, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

2Department of Pathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

3Department of Biophysics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

4Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

5Department of Molecular Biology, Babes-Bolyai University, Cluj-Napoca, Romania

Pub. Date: February 16, 2016

Cite this paper:
Andreea L. Rachisan, Alexandru Pirvan, Nicolae Miu, Dan Gheban, Adrian Hrusca, Gabriel Samasca and Iulia Lupan. Is HLA Typing a Diagnostic Tool in Celiac Disease?. International Journal of Celiac Disease. 2016; 4(1):9-10. doi: 10.12691/ijcd-4-1-10


The “four out of five rule” has not been officially endorsed by official guidelines. However, HLA-associated genes that predispose to CD are found in as much as 30–40% of healthy people. Thus, their presence seems too indecisive for the occurrence of CD.

celiac disease HLA children

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