International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: http://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2015, 3(4), 148-150
DOI: 10.12691/ijcd-3-4-6
Open AccessArticle

Celiac Disease and Cancer – Are There Potential Links? Is the Vigilance of Immune System in Celiac Disease a Double-edged Sword?

Jana Cizkova1, 2 and Monika Cervinkova1, 3,

1Laboratory of Tumour Biology, Institute of Animal Physiology and Genetics, v.v.i., Libechov, Czech Republic

2Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic

3Department of Surgery, 1st Medical Faculty, Charles University and Hospital Na Bulovce, Prague, Czech Republic

Pub. Date: November 16, 2015

Cite this paper:
Jana Cizkova and Monika Cervinkova. Celiac Disease and Cancer – Are There Potential Links? Is the Vigilance of Immune System in Celiac Disease a Double-edged Sword?. International Journal of Celiac Disease. 2015; 3(4):148-150. doi: 10.12691/ijcd-3-4-6

Abstract

Celiac disease (CD) is a chronic immune – mediated inflammatory intestinal disorder with prevalence about 1% of the West European population. The emergence of the disease is dependent on presence of grain storage proteins from wheat, barley, and rye (collectively called gluten) and genetic predisposition. After diagnosis is immediately deployed lifelong gluten free diet (GFD) to promote villous healing. In the case of CD - like other autoimmune disease, additional complications are observed especially if dietary compliance is poor. The most serious complications are malignancies including predominantly various types of lymphomas. On the other hand recent studies indicate lower risk of colon cancer in contrast to cutaneous malignant melanoma where the results are contradictory.

Keywords:
celiac disease malignancies lymphomas

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References:

[1]  Levy J, Bernstein L, Silber N: Celiac Disease: An Immune Dysregulation Syndrome. Current Problems in Pediatric and Adolescent Health Care 2014, 44(11):324-327.
 
[2]  Bao F, Bhagat G: Histopathology of celiac disease. Gastrointestinal endoscopy clinics of North America 2012, 22(4):679-694.
 
[3]  Dube C, Rostom A, Sy R, Cranney A, Saloojee N, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V et al: The prevalence of celiac disease in average-risk and at-risk Western European populations: A systematic review. Gastroenterology 2005, 128(4):S57-S67.
 
[4]  Silano M, Volta U, Mecchia AM, Dessi M, Di Benedetto R, De Vincenzi M, Italian Registry Complications C: Delayed diagnosis of coeliac disease increases cancer risk. Bmc Gastroenterology 2007, 7.
 
[5]  Tonutti E, Bizzaro N: Diagnosis and classification of celiac disease and gluten sensitivity. Autoimmunity Reviews 2014, 13(4-5):472-476.
 
[6]  Walker MM, Woodward J: A clinicopathological approach to the diagnosis of coeliac disease. Diagnostic Histopathology 2012, 18(10):402-410.
 
[7]  Viljamaa M, Kaukinen K, Pukkala E, Hervonen K, Reunala T, Collin P: Malignancies and mortality in patients with coeliac disease and dermatitis herpetiformis: 30-year population-based study. Digestive and Liver Disease 2006, 38(6):374-380.
 
[8]  Green PHR, Fleischauer AT, Bhagat G, Goyal R, Jabri B, Neugut AI: Risk of malignancy in patients with celiac disease. American Journal of Medicine 2003, 115(3):191-195.
 
[9]  Freeman HJ: Adult Celiac Disease and Its Malignant Complications. Gut and Liver 2009, 3(4):237-246.
 
[10]  Meijer JWR, Mulder CJJ, Goerres MG, Boot H, Schweizer JJ: Coeliac disease and (extra)intestinal T-cell lymphomas: definition, diagnosis and treatment. Scandinavian journal of gastroenterology Supplement 2004(241):78-84.
 
[11]  Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES: The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 2011, 117(19):5019-5032.
 
[12]  Shroff S, Ganapathi KA: Enteropathy associated T-cell lymphoma: a review of diagnostic findings and therapeutic strategies. Diagnostic Histopathology 2014, 20(4):151-155.
 
[13]  Chandesris MO, Malamut G, Verkarre V, Meresse B, Macintyre E, Delarue R, Rubio MT, Suarez F, Deau-Fischer B, Cerf-Bensussan N et al: Enteropathy-associated T-cell lymphoma: A review on clinical presentation, diagnosis, therapeutic strategies and perspectives. Gastroenterologie Clinique Et Biologique 2010, 34(11):590-605.
 
[14]  Delabie J, Holte H, Vose JM, Ullrich F, Jaffe ES, Savage KJ, Connors JM, Rimsza L, Harris NL, Mueller-Hermelink K et al: Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project. Blood 2011, 118(1):148-155.
 
[15]  van de Water JMW, Cillessen SAGM, Visser OJ, Verbeek WHM, Meijer CJLM, Mulder CJJ: Enteropathy associated T-cell lymphoma and its precursor lesions. Best Practice & Research in Clinical Gastroenterology 2010, 24(1):43-56.
 
[16]  Ahluwalia M, Gotlieb V, Damerla V, Saif MW: Aggressive Burkitt-like lymphoma of colon in a patient with prior celiac disease. The Yale journal of biology and medicine 2006, 79(3-4):173-175.
 
[17]  Tursi A, Inchingolo CD: Synchronous gastric and colonic MALT-lymphoma in coeliac disease: A long-term follow-up on gluten-free diet. Digestive and Liver Disease 2007, 39(11):1035-1038.
 
[18]  Cuoco L, Cammarota G, Tursi A, Papa A, Certo M, Cianci R, Fedeli G, Gasbarrini G: Disappearance of gastric mucosa-associated lymphoid tissue in coeliac patients after gluten withdrawal. Scandinavian Journal of Gastroenterology 1998, 33(4):401-405.
 
[19]  Volta U, Quintarelli F, Felli C, Silano M, Italian Registry Complications C: Low risk of colon cancer in patients with celiac disease. Scandinavian Journal of Gastroenterology 2014, 49(5):564-568.
 
[20]  Pereyra L, Gonzalez R, Mohaidle A, Fischer C, Mella JM, Panigadi GN, Manazzoni D, Matoso MD, Lasa JS, Novillo A et al: Risk of colorectal neoplasia in patients with celiac disease: a multicenter study. Journal of Crohn's & colitis 2013, 7(12):e672-677.
 
[21]  Green PHR, Jabri B: Celiac disease and other precursors to small-bowel malignancy. Gastroenterology Clinics of North America 2002, 31(2):625-+.
 
[22]  Green PHR, Jabri B: Coeliac disease. Lancet 2003, 362(9381):383-391.
 
[23]  Potter DD, Murray JA, Donohue JH, Burgart LJ, Nagorney DM, van Heerden JA, Plevak MF, Zinsmeister AR, Thibodeau SN: The role of defective mismatch repair in small bowel adenocarcinoma in celiac disease. Cancer Research 2004, 64(19):7073-7077.
 
[24]  Aparicio T, Zaanan A, Svrcek M, Laurent-Puig P, Carrere N, Manfredi S, Locher C, Afchain P: Small bowel adenocarcinoma: Epidemiology, risk factors, diagnosis and treatment. Digestive and Liver Disease 2014, 46(2):97-104.
 
[25]  Lebwohl B, Eriksson H, Hansson J, Green PHR, Ludvigsson JF: Risk of cutaneous malignant melanoma in patients with celiac disease: A population-based study. Journal of the American Academy of Dermatology 2014, 71(2):245-248.
 
[26]  Schmitz F, Herzig KH, Stuber E, Tiemann N, Reinecke-Luthge A, Nitsche R, Folsch UR: On the pathogenesis and clinical course of mesenteric lymph node cavitation and hyposplenism in coeliac disease. International Journal of Colorectal Disease 2002, 17(3):192-198.
 
[27]  Koo V, Armstrong A, Harvey C: Coeliac disease presenting with colonic lymphoma. Ulster Medical Journal 2002, 71(2):136-138.
 
[28]  Pulte D, Murray J: Celiac disease and diffuse T-cell lymphoma of the colon. Gastrointestinal Endoscopy 2001, 53(3):379-381.