International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2015, 3(3), 95-97
DOI: 10.12691/ijcd-3-3-1
Open AccessArticle

Diagnostics of Adult Forms of Celiac Disease: More Intensive Screening Improves Diagnosis

Peter Makovicky1, , Csaba Podlupszki2, Pavol Makovicky3, Gabriel Samasca4, Alexandra Rejhova5 and Hugh James Freeman6

1Czech Centre for Phenogenomics, Institute of Molecular Genetics, Department of Transgenic Models of Diseases, ASCR, Prague, Czech Republic

2Department of Gastroenterology, ForLife – General Hospital in Komarno, Slovak Republic

3Department of Biology, Pedagogical Faculty, Selye Janos University, Bratislavska, Slovak Republic

4Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

5Department of the Molecular Biology of Cancer, Institute of Experimental Medicine of the ASCR, Prague, Czech Republic

6Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada

Pub. Date: June 10, 2015

Cite this paper:
Peter Makovicky, Csaba Podlupszki, Pavol Makovicky, Gabriel Samasca, Alexandra Rejhova and Hugh James Freeman. Diagnostics of Adult Forms of Celiac Disease: More Intensive Screening Improves Diagnosis. International Journal of Celiac Disease. 2015; 3(3):95-97. doi: 10.12691/ijcd-3-3-1


Diagnosis of adult celiac disease is often a problematic part of clinical medicine. High risk groups for adult celiac disease deserve an intense search, even if atypical extra-intestinal symptoms suggest some other underlying cause. In part, diagnosis may occur over a long time period during adult years, and even then, could potentially remain undiagnosed until very late, even in very elderly stages of life. The objective of this work was to record our clinical experience with the diagnosis of adult forms of the celiac disease, in spite of their atypical presentations with extra-intestinal symptoms alone, and consider the role of serological testing for case-finding in these patients. We chose 9 adult patients with celiac disease diagnosed over a long period during an outpatient medical care by various physician specialists. Examination of autoantibodies for tissue transglutaminase, antiendomysium antibodies and autoantibodies against gliadin as well as cow's milk were done. To confirm positive autoantibodies as an indicator of adult celiac disease, samples of duodenal mucosa were taken and histopathologically examined.

celiac disease diagnostics adult patients screening hidden forms

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