Diagnostics of Adult Forms of Celiac Disease: More Intensive Screening Improves Diagnosis

Peter Makovicky^1, , Csaba Podlupszki², Pavol Makovicky³, Gabriel Samasca⁴, Alexandra Rejhova⁵ and Hugh James Freeman⁶

¹Czech Centre for Phenogenomics, Institute of Molecular Genetics, Department of Transgenic Models of Diseases, ASCR, Prague, Czech Republic

²Department of Gastroenterology, ForLife – General Hospital in Komarno, Slovak Republic

³Department of Biology, Pedagogical Faculty, Selye Janos University, Bratislavska, Slovak Republic

⁴Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

⁵Department of the Molecular Biology of Cancer, Institute of Experimental Medicine of the ASCR, Prague, Czech Republic

⁶Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada

Cite this paper:
Peter Makovicky, Csaba Podlupszki, Pavol Makovicky, Gabriel Samasca, Alexandra Rejhova and Hugh James Freeman. Diagnostics of Adult Forms of Celiac Disease: More Intensive Screening Improves Diagnosis. International Journal of Celiac Disease. 2015; 3(3):95-97. doi: 10.12691/ijcd-3-3-1

Abstract

Diagnosis of adult celiac disease is often a problematic part of clinical medicine. High risk groups for adult celiac disease deserve an intense search, even if atypical extra-intestinal symptoms suggest some other underlying cause. In part, diagnosis may occur over a long time period during adult years, and even then, could potentially remain undiagnosed until very late, even in very elderly stages of life. The objective of this work was to record our clinical experience with the diagnosis of adult forms of the celiac disease, in spite of their atypical presentations with extra-intestinal symptoms alone, and consider the role of serological testing for case-finding in these patients. We chose 9 adult patients with celiac disease diagnosed over a long period during an outpatient medical care by various physician specialists. Examination of autoantibodies for tissue transglutaminase, antiendomysium antibodies and autoantibodies against gliadin as well as cow's milk were done. To confirm positive autoantibodies as an indicator of adult celiac disease, samples of duodenal mucosa were taken and histopathologically examined.

Keywords:
celiac disease diagnostics adult patients screening hidden forms

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