International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2015, 3(2), 75-76
DOI: 10.12691/ijcd-3-2-2
Open AccessArticle

Potential Role of Bordetella Pertussis in Celiac Disease

Keith Rubin1 and Steven Glazer1,

1ILiAD Biotechnologies LLC, New York City, 10003 United States of America

Pub. Date: March 27, 2015

Cite this paper:
Keith Rubin and Steven Glazer. Potential Role of Bordetella Pertussis in Celiac Disease. International Journal of Celiac Disease. 2015; 3(2):75-76. doi: 10.12691/ijcd-3-2-2


We discuss the correlation between the incidence of acute clinical Bordetella pertussis infection and celiac disease in children < 2 years of age during the Swedish celiac disease epidemic of the 1980s and 1990s.

celiac disease Bordetella pertussis subclinical Bordetella pertussis colonization (SCBPC)

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[1]  Korneychuk, N., B. Meresse, and N. Cerf-Bensussan, Lessons from rodent models in celiac disease. Mucosal immunology, 2014.
[2]  Chen, X., et al., Pertussis toxin as an adjuvant suppresses the number and function of CD4+ CD25+ T regulatory cells. European Journal of Immunology, 2006. 36(3): p. 671-680.
[3]  Kosecka, U., M.C. Berin, and M.H. Perdue, Pertussis adjuvant prolongs intestinal hypersensitivity. International archives of allergy and immunology, 1999. 119(3): p. 205-11.
[4]  Rubio-Tapia, A., et al., Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology, 2009. 137(1): p. 88-93.
[5]  Warfel, J.M., L.I. Zimmerman, and T.J. Merkel, Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model. Proceedings of the National Academy of Sciences, 2014. 111(2): p. 787-792.
[6]  Zhang, Q., et al., Prevalence of asymptomatic Bordetella pertussis and Bordetella parapertussis infections among school children in China as determined by pooled real-time PCR: A cross-sectional study. Scandinavian journal of infectious diseases, 2014. 46(4): p. 280-287.
[7]  Olin, P., et al., Declining pertussis incidence in Sweden following the introduction of acellular pertussis vaccine. Vaccine, 2003. 21(17-18): p. 2015-21.
[8]  Waker-Smith, J., et al., Revised criteria for diagnosis of celiac disease. Report of Working Group of European Society of Pediatric Gastroenterology and Nutrition. Arch Dis Child, 1990. 65: p. 909-11.
[9]  Olsson, C., et al., Difference in celiac disease risk between Swedish birth cohorts suggests an opportunity for primary prevention. Pediatrics, 2008. 122(3): p. 528-34.
[10]  Myleus, A., et al., Early vaccinations are not risk factors for celiac disease. Pediatrics, 2012. 130(1): p. e63-70.