International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
Open Access
Journal Browser
International Journal of Celiac Disease. 2015, 3(2), 72-74
DOI: 10.12691/ijcd-3-2-11
Open AccessArticle

Transient Anti TG2 Autoantibodies in Systemic Lupus Erythematosus: A Window to Autoimmunity

Aaron Lerner1, 2, , Kai Prager2 and Torsten Matthias2

1Bruce Rappaport School of Medicine, Technion-Israel institute of Technology, Haifa, Israel

2Aesku.Kipp Institute, Wendelsheim, Germany

Pub. Date: June 05, 2015

Cite this paper:
Aaron Lerner, Kai Prager and Torsten Matthias. Transient Anti TG2 Autoantibodies in Systemic Lupus Erythematosus: A Window to Autoimmunity. International Journal of Celiac Disease. 2015; 3(2):72-74. doi: 10.12691/ijcd-3-2-11


Transient anti transglutaminase2 and anti endomysial antibody elevation in systemic lupus erythematosus is fundamentally thought-provoking with respect to establishment of autoimmunity and its progression. Celiac disease and systemic lupus erythematosus are both relayed within the mosaic framework of autoimmunity. Transglutaminase2 is a multifunctional enzyme, involved in cell biology and survival and is one of the post translational modifiers of protein, enhancing autoimmunity. TG2 and its specific antibodies are heavily involved in celiac disease. TG2 is essential in clearance of apoptotic cells and experimentally participates in systemic lupus-like induction. However, the role of anti TG2 autoantibodies is far from being unraveled. Despite disappearance of these antibodies on gluten containing diet, in the present case, the boy is at risk of developing celiac disease in the future.

tissue transglutaminase anti-TG2 autoantibodies systemic lupus erythematosus celiac disease autoimmunity

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Spârchez M, Pîrvan A, Miu N, Samasca G, Simionescu B, Rednic S. Transient Coeliac Disease Specific Antibodies in Systemic Lupus Erythematosus: Case Report. International Journal of Celiac Disease. 2015; 3: 37-39.
[2]  Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54(1): 136-160.
[3]  Makker SP. Suppression of induced humoral autoimmune response by dexamethasone in rats. Clin Exp Immunol. 1978 ; 34: 436-40.
[4]  Hojsak , Zevit N, Waisbourd-Zinman O, Rosenbach Y, Mozer-Glassberg Y, Shalitin S, Phillip M, Shamir R. Concomitant autoantibodies in newly diagnosed diabetic children with transient celiac serology or proven celiac disease. J Pediatr Endocrinol Metab. 2013; 26: 1099-104.
[5]  Collin P, Kurppa K, Lindfors K, Mäki M, Kaukinen K. Transient celiac autoimmunity or just temporary fluctuation? J Clin Gastroenterol. 2012; 46: 432-3
[6]  Ludvigsson JF, Rubio-Tapia A, Chowdhary V, Murray JA, Simard JF. Increased risk of systemic lupus erythematosus in 29,000 patients with biopsy-verified celiac disease. J Rheumatol. 2012; 39: 1964-70.
[7]  Lerner A, Blank M, Shoenfeld Y. Increased prevalence of autoantibodies in celiac disease. Dig Dis Sci 1998; 43: 723-726.
[8]  Swissa M, Lerner A, Sasaki T, Sela E, Blank M, Shoenfeld Y. The diverse pathogenic potential of anti-DNA antibodies from various sources to induce experimental systemic lupus erythematosus. Pathobiology 1996; 64: 32-39.
[9]  Shaoul R, Lerner A. Associated autoantibodies in celiac disease. Autoimmun Rev. 2007; 6: 559-65.
[10]  Lauret E, Rodrigo L. Celiac disease and autoimmune-associated conditions. Biomed Res Int. 2013; 2013: 127589.
[11]  Hadjivassiliou M, Sanders DS, Grünewald RA, Akil M. Gluten sensitivity masquerading as systemic lupus erythematosus. Ann Rheum Dis. 2004; 63: 1501-3.
[12]  Salmi TT, Collin P, Järvinen O, Haimila K, Partanen J, et al. Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease. Aliment Pharmacol Ther. 2006; 24: 541-52.
[13]  Lindfors K, Kaukinen K. Contribution of celiac disease autoantibodies to the disease process. Expert Rev Clin Immunol. 2012; 8: 151-4.
[14]  Esposito C, Paparo F, Caputo I, Rossi M, Maglio M, Sblattero D et al. Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Gut. 2002; 51: 177-81.
[15]  Paolella G, Caputo I, Marabotti A, Lepretti M, Salzano AM, Scaloni A, et al. Celiac anti-type 2 transglutaminase antibodies induce phosphoproteome modification in intestinal epithelial Caco-2 cells. PLoS One. 2013; 8: e84403.
[16]  Szondy Z, Korponay-Szabó I, Király R, Fésüs L. Transglutaminase 2 dysfunctions in the development of autoimmune disorders: celiac disease and TG2-/- mouse. Adv Enzymol Relat Areas Mol Biol. 2011; 78: 295-345.
[17]  Marai I, Shoenfeld Y, Bizzaro N, Villalta D, Doria A, Tonutti E, Tozzoli R. IgA and IgG tissue transglutaminase antibodies in systemic lupus erythematosus. Lupus. 2004; 13: 241-4.