International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
Open Access
Journal Browser
International Journal of Celiac Disease. 2014, 2(3), 118-118
DOI: 10.12691/ijcd-2-3-9
Open AccessCase Report

Social Aspects of Gluten-free Living

Diana Deleanu1, 2, Nicolae Miron1, 2, Iulia Lupan3 and Gabriel Samasca1, 4,

1Department of Immunology and Allergology; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

2Department of Internal Medicine, Regional Institute of Gastroenterology and Hepatology "Prof. Dr. Octavian Fodor"

3Molecular Biology Center, Institute for Interdisciplinary Research on Bio-Nano-Sciences, “Babes-Bolyai” University,

4Cluj-Napoca, Romania

Pub. Date: September 21, 2014

Cite this paper:
Diana Deleanu, Nicolae Miron, Iulia Lupan and Gabriel Samasca. Social Aspects of Gluten-free Living. International Journal of Celiac Disease. 2014; 2(3):118-118. doi: 10.12691/ijcd-2-3-9



Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Marsh MN: Gluten, major histocompatibility complex and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘coeliac sprue’). Gastroenterology, 1992; 102: 330-354.
[2]  Oberhuber G, Granditsch G, Vogelsang H: The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur. J. Gastroenterol. Hepatol. 1999;11: 1185-1194.
[3]  Hopman EG, von Blomberg ME, Batstra MR et al: Gluten tolerance in adult patients with celiac disease 20 years after diagnosis? Eur J Gastroenterol Hepatol 2008; 20(5): 423-429.
[4]  Limbach A, Hoepffner W, Tannapfel A et al: Verlaufsbeobachtung von Zöliakiepatienten im Kindes- und jungen Erwachsenenalter: latente oder transiente Zöliakie? Klin Padiatr 2003; 215(2): 76-81.
[5]  Henriksson C, Boström AM, Wiklund IE: What effect does breastfeeding have on coeliac disease? A systematic review update. Evid Based Med 2013; 18(3): 98-103.
[6]  Husby S, Koletzko S, et al, ESPGHAN working group: European Society for Pediatric gastroenterology, hepatology and Nutrition Guidelines for the diagnosis of Coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54:136-160.
[7]  Myléus A, Hernell O, Gothefors L et al: Early infections are associated with increased risk for celiac disease: an incident case-referent study. BMC Pediatr 2012; 12: 194.
[8]  Dolcino M, Zanoni G, Bason C et al: A subset of anti-rotavirus antibodies directed against the viral protein VP7 predicts the onset of celiac disease and induces typical features of the disease in the intestinal epithelial cell line T84. Immunol Res 2013; 56(2-3): 465-476.
[9]  Riddle MS, Murray JA, Cash BD, Pimentel M, Porter CK: Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness: a retrospective cohort study. Dig Dis Sci. 2013; 58(11): 3242-3245.
[10]  Lebwohl B, Blaser MJ, Ludvigsson JF et al: Decreased risk of celiac disease in patients with Helicobacter pylori colonization. Am J Epidemiol 2013; 178(12): 1721-1730.
[11]  McSorley HJ, Gaze S, Daveson J et al: Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection. PLoS One 2011; 6(9):e24092.
[12]  Croese J, Gaze ST, Loukas A: Changed gluten immunity in celiac disease by Necator americanus provides new insights into autoimmunity. Int J Parasitol 2013; 43(3-4): 275-282.
[13]  Mårild K, Stephansson O, Montgomery S et al: Pregnancy outcome and risk of celiac disease in offspring: a nationwide case-control study. Gastroenterology 2012; 142(1): 39-45.
[14]  Leffler DA, Kelly CP, Abdallah HZ et al: A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. Am J Gastroenterol. 2012; 107(10): 1554-1562.
[15]  Bjarnason I: Intestinal permeability. Gut 1994; 35(1 Suppl): S18-22.
[16]  Cobden I, Rothwell J, Axon AT: Intestinal permeability and screening tests for coeliac disease. Gut 1980; 21(6): 512-518.
[17]  Hamilton I, Cobden I, Rothwell J, Axon AT: Intestinal permeability in coeliac disease: the response to gluten withdrawal and single-dose gluten challenge. Gut 1982; 23 (3): 202-210.
[18]  Kohout P: Small bowel permeability in diagnosis of celiac disease and monitoring of compliance of a gluten-free diet (gut permeability in celiac disease). Acta Medica (Hradec Kralove. 2001; 44(3): 101-104.
[19]  Fernández-Blanco JA, Barbosa S, Sánchez de Medina F et al: Persistent epithelial barrier alterations in a rat model of postinfectious gut dysfunction. Neurogastroenterol Motil 2011; 23(11): e523-33.
[20]  Hietbrink F, Besselink MG, Renooij W et al: Systemic inflammation increases intestinal permeability during experimental human endotoxemia. Shock 2009; 32(4): 374-378.
[21]  Pape HC, Dwenger A, Regel G et al: Increased gut permeability after multiple trauma. Br J Surg 1994; 81(6): 850-852.
[22]  Fink MP: Effect of critical illness on microbial translocation and gastrointestinal mucosa permeability. Semin Respir Infect 1994; 9 (4): 256-260.
[23]  Holland J, Carey M, Hughes N et al: Intraoperative splanchnic hypoperfusion, increased intestinal permeability, down-regulation of monocyte class II major histocompatibility complex expression, exaggerated acute phase response, and sepsis. Am J Surg 2005; 190 (3): 393-400.
[24]  Messick WJ, Koruda M, Meyer A, Zimmerman K: Differential changes in intestinal permeability following burn injury. J Trauma 1994; 36 (3): 306-311
[25]  Ryan CM, Yarmush ML, Burke JF, Tompkins RG: Increased gut permeability early after burns correlates with the extent of burn injury. Crit Care Med 1992; 20(11): 1508-1512.
[26]  Demling RH: Early increased gut permeability after burns. Crit Care Med 1992; 20(11):1503.
[27]  Kohout P: Small bowel permeability examination - review. Czech and Slovak Gastroenterology 1998; 52(Suppl.1): 15-27.
[28]  Cinova J, De Palma G, Stepankova R et al: Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats. PLoS One 2011; 6(1): e16169.
[29]  Lindfors K, Blomqvist T, Juuti-Uusitalo K et al: Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol 2008; 152(3): 552-558.
[30]  Bakshi A, Stephen S, Borum ML, Doman DB: Emerging therapeutic options for celiac disease: potential alternatives to a gluten-free diet. Gastroenterol Hepatol (NY) 2012; 8 (9): 582-8.
[31]  Lamprecht M, Frauwallner A. Exercise, intestinal barrier dysfunction and probiotic supplementation. Med Sport Sci 2012; 59: 47-56.
[32]  Freeman HJ: Non-dietary forms of treatment for adult celiac disease. World J Gastrointest Pharmacol Ther 2013; 4(4): 108-112.
[33]  Auricchio S: An innovative approach to measure compliance to a gluten-free diet. Am J Clin Nutr. 2012; 95(3): 537-538.
[34]  Comino I, Real A, Vivas S, Síglez MÁ et al: Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces. Am J Clin Nutr 2012; 95: 670-677.
[35]  Biagi F, Bianchi PI, Marchese A, Trotta L et al: A score that verifies adherence to a gluten-free diet: a cross-sectional, multicentre validation in real clinical life. Br J Nutr 2012; 108 (10): 1884-1888.
[36]  Esteve M, Carrasco A, Fernandēz-Bañares F: Is a gluten-free diet necessary in Marsh I intestinal lesions in patients with HLADQ2, DQ8 genotype and without gastrointestinal symptoms? Curr Opin Clin Nutr Metab Care 2012; 15(5): 505-510.
[37]  Kurppa K, Collin P, Viljamaa M et al: Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study. Gastroenterology 2009; 136(3): 816-823.
[38]  Carroccio A, Ambrosiano G, Di Prima L et al: Clinical symptoms in celiac patients on a gluten-free diet. Scand J Gastroenterol. 2008; 43(11): 1315-1321.
[39]  Murray JA, McLachlan S, Adams PC et al: Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. Clin Gastroenterol Hepatol. 2013; 11(7): 808-814.
[40]  Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, Mulder CJ, van Bodegraven AA: Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients 2013; 5(10): 3975-3992.
[41]  Mones RL, Yankah A, Duelfer D, Bustami R, Mercer G. Disaccharidase deficiency in pediatric patients with celiac disease and intact villi. Scand J Gastroenterol 2011; 46(12): 1429-1434.
[42]  Kabbani TA, Goldberg A, Kelly CP et al: Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther 2012; 35(6): 723-729.
[43]  Diamanti A, Capriati T, Basso MS et al: Celiac disease and overweight in children: an update. Nutrients 2014; 6(1): 207-220.
[44]  Saturni L, Ferretti G, Bacchetti T: The gluten-free diet: safety and nutritional quality. Nutrient. 2010; 2(1): 16-34.
[45]  Catassi C Fabiani E, Iacono G et al: A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with coeliac disease. Am J Clin Nutr 2007, 85(1): 160-166.
[46]  Biesiekierski JR, Muir JG, Gibson PR: Is gluten a cause of gastrointestinal symptoms in people without celiac disease? Curr Allergy Asthma Rep 2013; 13(6): 631-638.
[47]  Verdu EF, Armstrong D, Murray JA: Between celiac disease and irritable bowel syndrome: The ‘No Man’s Land’ of Gluten Sensitivity. Am J Gastroenterol 2009; 104(6): 1587-1594.