International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2014, 2(3), 89-92
DOI: 10.12691/ijcd-2-3-5
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Mucosal Architectural Rearrangement in Coeliac Disease

Erna Sziksz1, 2, , Apor Veres-Székely1, 2, Domonkos Pap2, Andrea Fekete2, 3, Gábor Veres1, Tivadar Tulassay1, 2, Attila Szabó2 and Ádám Vannay1, 2

1MTA-SE, Pediatrics and Nephrology Research Group, H-1083, Budapest, Hungary

2First Department of Pediatrics, Semmelweis University, H-1083, Budapest, Hungary

3MTA-SE, Lendület Diabetes Research Group, H-1083 Budapest, Hungary

Pub. Date: September 17, 2014

Cite this paper:
Erna Sziksz, Apor Veres-Székely, Domonkos Pap, Andrea Fekete, Gábor Veres, Tivadar Tulassay, Attila Szabó and Ádám Vannay. Mucosal Architectural Rearrangement in Coeliac Disease. International Journal of Celiac Disease. 2014; 2(3):89-92. doi: 10.12691/ijcd-2-3-5


Celiac disease (CD) is the most common autoimmune enteropathy in the western world caused by the intolerance to gluten in genetically predisposed individuals. CD is characterized by a remarkable rearrangement of the mucosal architecture, in which process myofibroblasts play a crucial role. Myofibroblasts (intestinal subepithelial myofibroblasts and interstitial cells of Cajal) are the most represented mesenchymal cell types in the gut mucosa and are involved in a broad range of biological processes including growth, mucosal protection, repair, inflammation and fibrosis. Myofibroblasts actively contribute to the mucosal changes in CD due to their ability to produce an excessive amount of extracellular matrix and basement membrane components (e.g. collagens, fibronectin, and specific enzymes including tissue transglutaminases) and through the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs). The enhanced production of ECM components and MMPs and the altered shape and motility of myofibroblasts in the duodenal mucosa of patients with CD suggest that myofibroblasts may play an essential role in the pathogenesis of CD.

celiac disease myofibroblast extracellular matrix tissue transglutaminase matrix metalloproteinase

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[1]  Leslie C, Mews C, Charles A, Ravikumara M. Celiac disease and eosinophilic esophagitis: a true association. J Pediatr Gastroenterol Nutr 2010; 50: 397-9.
[2]  Stewart MJ, Shaffer E, Urbanski SJ, Beck PL, Storr MA. The association between celiac disease and eosinophilic esophagitis in children and adults. BMC Gastroenterol 2013; 13: 11.
[3]  Ludvigsson JF, Aro P, Walker MM, Vieth M, Agréus L, Talley NJ, Murray JA, Ronkainen J. Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult population-based study. Scand J Gastroenterol 2013; 48: 808-14.
[4]  Thompson JS, Lebwohl B, Reilly NR, Talley NJ, Bhagat G, Green PH. Increased incidence of eosinophilic esophagitis in children and adults with celiac disease. J ClinGastroenterol 2012; 46: e6-e11.
[5]  Pellicano R, De Angelis C, Ribaldone DG, Fagoonee S, Astegiano M. 2013 update on celiac disease and eosinophilicesophagitis. Gluten-free diet does not appear to induce endoscopic remission of eosinophilic esophagitis in children with coexistent celiac disease. Nutrients 2013; 5: 3329-36.
[6]  Sánchez-García S, Ibáñez MD, Martinez-Gómez MJ, Escudero C, Vereda A, Fernández-Rodríguez M, Rodríguez del Río P. Eosinophilic esophagitis, celiac disease, and immunoglobulin E-mediated allergy in a 2-year-old child. J Investig Allergol Clin Immunol 2011; 21: 73-5.
[7]  Soon IS, Butzner JD, Kaplan GG, deBruyn JC. Incidence and prevalence of eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr 2013; 57: 72-80.
[8]  Atkins D, Furuta GT. Mucosal immunology, eosinophilic esophagitis, and other intestinal inflammatory diseases. J Pediatr Gastroenterol Nutr 2013; 57: 72-80.
[9]  Lucendo AJ, Arias Á, Pérez-Martínez I, López-Vázquez A, Ontañón-Rodríguez J, González-Castillo S, De Rezende LC, Rodrigo L. Adult patients with eosinophilic esophagitis do not show an increased frequency of the HLA-DQ2/DQ8 genotypes predisposing to celiac disease. Dig Dis Sci 2011; 56: 1107-11.
[10]  Lucendo AJ. Esophageal manifestations of celiac disease. Dis Esophagus 2011; 24: 470-5.
[11]  Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol 2014; 46: 225-40.
[12]  Bordea MA, Mosteanu O, Pop TA, Gheban D, Samasca G, Miu N. Eosinophilic esophagitis. Acta Gastro-Enterologica Belgica 2013; 76: 407-412.