International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: http://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2014, 2(3), 89-92
DOI: 10.12691/ijcd-2-3-5
Open AccessReview Article

Mucosal Architectural Rearrangement in Coeliac Disease

Erna Sziksz1, 2, , Apor Veres-Székely1, 2, Domonkos Pap2, Andrea Fekete2, 3, Gábor Veres1, Tivadar Tulassay1, 2, Attila Szabó2 and Ádám Vannay1, 2

1MTA-SE, Pediatrics and Nephrology Research Group, H-1083, Budapest, Hungary

2First Department of Pediatrics, Semmelweis University, H-1083, Budapest, Hungary

3MTA-SE, Lendület Diabetes Research Group, H-1083 Budapest, Hungary

Pub. Date: September 17, 2014

Cite this paper:
Erna Sziksz, Apor Veres-Székely, Domonkos Pap, Andrea Fekete, Gábor Veres, Tivadar Tulassay, Attila Szabó and Ádám Vannay. Mucosal Architectural Rearrangement in Coeliac Disease. International Journal of Celiac Disease. 2014; 2(3):89-92. doi: 10.12691/ijcd-2-3-5

Abstract

Celiac disease (CD) is the most common autoimmune enteropathy in the western world caused by the intolerance to gluten in genetically predisposed individuals. CD is characterized by a remarkable rearrangement of the mucosal architecture, in which process myofibroblasts play a crucial role. Myofibroblasts (intestinal subepithelial myofibroblasts and interstitial cells of Cajal) are the most represented mesenchymal cell types in the gut mucosa and are involved in a broad range of biological processes including growth, mucosal protection, repair, inflammation and fibrosis. Myofibroblasts actively contribute to the mucosal changes in CD due to their ability to produce an excessive amount of extracellular matrix and basement membrane components (e.g. collagens, fibronectin, and specific enzymes including tissue transglutaminases) and through the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs). The enhanced production of ECM components and MMPs and the altered shape and motility of myofibroblasts in the duodenal mucosa of patients with CD suggest that myofibroblasts may play an essential role in the pathogenesis of CD.

Keywords:
celiac disease myofibroblast extracellular matrix tissue transglutaminase matrix metalloproteinase

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