International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: http://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2021, 9(2), 65-67
DOI: 10.12691/ijcd-9-2-8
Open AccessArticle

Immunological Implications in Atopic Dermatitis

Emanuela Duca1, Genel Sur1, Teodora-Maria Zahariuc1, Gabor Maak1 and Lucia Sur2,

1Emergency Hospital for Children, Cluj-Napoca 3400, Romania

2Department of Pediatrics I, Iuliu Hatieganu University, Cluj-Napoca 3400, Romania

Pub. Date: May 18, 2021

Cite this paper:
Emanuela Duca, Genel Sur, Teodora-Maria Zahariuc, Gabor Maak and Lucia Sur. Immunological Implications in Atopic Dermatitis. International Journal of Celiac Disease. 2021; 9(2):65-67. doi: 10.12691/ijcd-9-2-8

Abstract

Both the inborn and acquired immune system plays an important role in the pathogenicity of atopic dermatitis (AD). The skin lesions are mostly due to the complex interaction of the cytokines, above all the ones secreted by the T helper 2 lymphocytes (Th2). In the acute phase of the disease, the most important cytokines are IL-4, IL-5 and IL-13, and also the subsequent activation of mastocytes and eosinophiles. The next step is the production of antigen-specific antibodies. The Th2 immune response is initiated by IL-1, IL-25, IL-17, IL-33 and by thymic stromal lymphopoietin (TSLP). Th2 cytokines block the expression of differentiation of certain proteins, like locrine, filaggrin, involucrin, and at the same time, they reduce the beta-antimicrobial peptide levels, disturbing the skin barrier in the process. In the chronic phase of the illness, the Th2 cytokines are predominant, with varying levels of T helper 17 cytokines.

Keywords:
atopic dermatitis allergic immunological factors evaluation

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