International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2020, 8(1), 32-34
DOI: 10.12691/ijcd-8-1-6
Open AccessArticle

Olmesartan-Induced Collagenous Sprue

Hugh James Freeman1,

1Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada

Pub. Date: April 27, 2020

Cite this paper:
Hugh James Freeman. Olmesartan-Induced Collagenous Sprue. International Journal of Celiac Disease. 2020; 8(1):32-34. doi: 10.12691/ijcd-8-1-6


A 65-yr-old female with diarrhea for 3 months and weight loss was evaluated. There was no travel or family history, but she had been treated with olmesartan for an elevated blood pressure. Fecal studies for an infectious cause were negative and serological studies for celiac disease were negative. A small bowel biopsy showed changes of collagenous sprue. The drug was discontinued. Diarrhea ceased and she regained her weight. Repeat biopsies of the small bowel were normal. Except for cessation of the olmesartan, no other dietary (eg., gluten-free diet) or treatment medication (eg., steroids) was provided. Long-term follow-up revealed no recurrence of symptoms in patients with sprue-like intestinal disease or collagenous sprue, consideration should be given to a drug-induced cause. This may limit the need for further clinical studies, restrictive diets or powerful prescribed medications, including steroids and immunosuppressive agents.

collagenous sprue celiac disease drug-induced small bowel disease olmesartan sprue-like enteropathy angiotensin-II inhibitor

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